产品名称

英文名称：Retapamulin

同义词

DTXSID30181492、HY-17010、Altargo、RETAPAMULIN [MI]、RETAPAMULIN [INN]、(3aS,4R,5S,6S,8R,9R,9aR,10R)-2-(exo-8-Methyl-8-azabicyclo[3.2.1]octan-3-ylsulfanyl)acetic acid 5-hydroxy-4,6,9,10-tetramethyl-1-oxo-6-vinylperhydro-3a,9-propanocyclopentacycloocten-8-yl es、瑞他帕林

产品性质

CAS编号：224452-66-8

分子式：C30H47NO4S

分子量：517.76

PubChem编号：6918462

别名：瑞他帕林

英文别名：DTXSID30181492|HY-17010|Altargo|RETAPAMULIN [MI]|RETAPAMULIN [INN]|(3aS,4R,5S,6S,8R,9R,9aR,10R)-2-(exo-8-Methyl-8-azabicyclo[3.2.1]octan-3-ylsulfanyl)acetic acid 5-hydroxy-4,6,9,10-tetramethyl-1-oxo-6-vinylperhydro-3a,9-propanocyclopentacycloocten-8-yl es

规格或纯度：≥99%

英文名称：Retapamulin

生化机理：Retapamulin(SB-275833) is a topical antibiotic developed by GlaxoSmithKline. Retapamulin(SB-275833) is the first drμg in the new class of pleuromutilin antibiotics to be approved for human use.Retapamulin(SB-275833) is marketed as an ointment under the brand names Altabax and Altargo. Retapamulin(SB-275833) is useful for Antibiotics.Retapamulin is a semi-synthetic pleuormutilin prepared by reacting pleuromutilin tosylate with tropine-3-thiol to give a more hydrophobic analogue with a tertiary amine. This enables formulation as a stable hydrochloride salt. Retapamulin is a broad spectrum antibiotic with no cross resistance to existing antibiotic classes, and is the first pleuromutilin approved for human use. Like all the pleuromutilins, retapamulin inhibits protein synthesis by binding to domain V of 23S rRNA.

储存温度：-20°C储存

运输条件：超低温冰袋运输

备注：50mg卖完停产，不再备货

产品介绍：Retapamulin是一种局部抗生素,可以结合大肠杆菌和金黄色葡萄球菌核糖体，效果类似，Kd值为3 nM.A broad spectrum antibiotic with no cross resistance to existing classesRetapamulin is a topical antibiotic, which binds to both E. coli and S. aureus ribosomes with similar potencies with Kd of 3 nM.A broad spectrum antibiotic with no cross resistance to existing classes

ALogP：6.1

IUPAC Name：[(1S,2R,3S,4S,6R,7R,8R,14R)-4-ethenyl-3-hydroxy-2,4,7,14-tetramethyl-9-oxo-6-tricyclo[5.4.3.01,8]tetradecanyl] 2-[[(1R,5S)-8-methyl-8-azabicyclo[3.2.1]octan-3-yl]sulfanyl]acetate

INCHI：InChI=1S/C30H47NO4S/c1-7-28(4)16-24(35-25(33)17-36-22-14-20-8-9-21(15-22)31(20)6)29(5)18(2)10-12-30(19(3)27(28)34)13-11-23(32)26(29)30/h7,18-22,24,26-27,34H,1,8-17H2,2-6H3/t18-,19+,20-,21+,22?,24-,26+,27+,28-,29+,30+/m1/s1

InChi Key：STZYTFJPGGDRJD-FJJJPKKESA-N

Canonical SMILES：CC1CCC23CCC(=O)C2C1(C(CC(C(C3C)O)(C)C=C)OC(=O)CSC4CC5CCC(C4)N5C)C

Isomeric SMILES：C[C@@H]1CC[C@@]23CCC(=O)[C@H]2[C@@]1([C@@H](C[C@@]([C@H]([C@@H]3C)O)(C)C=C)OC(=O)CSC4C[C@H]5CC[C@@H](C4)N5C)C

PubChem CID：6918462

CAS Registry No.：224452-66-8

Antibiotic DB：1994

溶解性：DMSO 104 mg/mL ;Water <1 mg/mL;Ethanol 104 mg/mL

象形图：

信号词：Warning

危险声明：H315 Causes skin irritationH319 Causes serious eye irritationH335 May cause respiratory irritationH412 Harmful to aquatic life with long lasting effectsH302 Harmful if swallowedH312 Harmful in contact with skin

预防措施声明：P261,P305+P351+P338,P273,P280,P302+P352,P321,P405,P501,P264,P271,P270,P304+P340,P403+P233,P362+P364,P330,P264+P265,P301+P317,P317,P337+P317,P332+P317,P319

产品包装