产品名称

英文名称：GW842166X

同义词

666260-75-9、GW842166X、GW 842166X、GW-842166X、GW842166、GW-842,166X、2-((2,4-dichlorophenyl)amino)-N-((tetrahydro-2H-pyran-4-yl)methyl)-4-(trifluoromethyl)pyrimidine-5-carboxamide、GW 842166、GW-842166、VL1I6P2DZ8、CHEMBL225411、842166X、2-(2,4-Dichloroanilino)-N-(

产品性质

CAS编号：666260-75-9

分子式：C18H17Cl2F3N4O2

分子量：449.25

PubChem编号：10253143

英文别名：666260-75-9|GW842166X|GW 842166X|GW-842166X|GW842166|GW-842,166X|2-((2,4-dichlorophenyl)amino)-N-((tetrahydro-2H-pyran-4-yl)methyl)-4-(trifluoromethyl)pyrimidine-5-carboxamide|GW 842166|GW-842166|VL1I6P2DZ8|CHEMBL225411|842166X|2-(2,4-Dichloroanilino)-N-(

规格或纯度：≥98%

英文名称：GW842166X

生化机理：GW842166X has an oral bioavailability of 58% and a half-life of 3 h when dosed orally in the rat. GW842166X has extremely high potency with an oral ED50 of 0.1 mg/kg and shows full reversal of hyperalgesia at 0.3 mg/kg in the FCAa model of inflammatory pain. GW842166X orally administrated at a dose of 15 mg/kg for 8 days produced a significant reversal of the CCI induced decrease in paw withdrawal threshold in a rat model of neuropathic pain.

储存温度：-20°C储存

运输条件：超低温冰袋运输

备注：卖完停产，不再备货

产品介绍：GW842166X is a potent and highly selective agonist of cannabinoid receptor CB2 receptor with EC50 of 63 nM, shows no significant activity at CB1 receptor.An agonist of the CB2 receptorGW842166X is a potent and highly selective agonist of cannabinoid receptor CB2 receptor with EC50 of 63 nM, shows no significant activity at CB1 receptor.An agonist of the CB2 receptor

ALogP：4.1

IUPAC Name：2-(2,4-dichloroanilino)-N-(oxan-4-ylmethyl)-4-(trifluoromethyl)pyrimidine-5-carboxamide

INCHI：InChI=1S/C18H17Cl2F3N4O2/c19-11-1-2-14(13(20)7-11)26-17-25-9-12(15(27-17)18(21,22)23)16(28)24-8-10-3-5-29-6-4-10/h1-2,7,9-10H,3-6,8H2,(H,24,28)(H,25,26,27)

InChi Key：TWQYWUXBZHPIIV-UHFFFAOYSA-N

Canonical SMILES：C1COCCC1CNC(=O)C2=CN=C(N=C2C(F)(F)F)NC3=C(C=C(C=C3)Cl)Cl

Isomeric SMILES：C1COCCC1CNC(=O)C2=CN=C(N=C2C(F)(F)F)NC3=C(C=C(C=C3)Cl)Cl

PubChem CID：10253143

溶解性：DMSO 20 mg/mL Water <1 mg/mL Ethanol <1 mg/mL

产品包装