产品名称

英文名称：Regorafenib (BAY 73-4506)

同义词

Regorafenib、755037-03-7、BAY 73-4506、Stivarga、4-(4-(3-(4-Chloro-3-(trifluoromethyl)phenyl)ureido)-3-fluorophenoxy)-N-methylpicolinamide、Regorafenibum、BAY73-4506、Regorafenib (BAY 73-4506)、BAY-73-4506、4-[4-({[4-Chloro-3-(trifluoromethyl)phenyl]carbamoyl}amin

产品性质

CAS编号：755037-03-7

分子式：C21H15ClF4N4O3

分子量：482.82

MDL号：MFCD16038047

PubChem编号：11167602

英文别名：Regorafenib|755037-03-7|BAY 73-4506|Stivarga|4-(4-(3-(4-Chloro-3-(trifluoromethyl)phenyl)ureido)-3-fluorophenoxy)-N-methylpicolinamide|Regorafenibum|BAY73-4506|Regorafenib (BAY 73-4506)|BAY-73-4506|4-[4-({[4-Chloro-3-(trifluoromethyl)phenyl]carbamoyl}amin

规格或纯度：≥99%

英文名称：Regorafenib (BAY 73-4506)

生化机理：VEGFR1，VEGFR2，VEGFR3，PDGFRβ，c-Kit，RET和Raf-1的有效xa0多激酶抑制剂（IC 50值分别为13、4.2、46、22、7、1.5和2.5nM）。口服生物利用的抗肿瘤，抗血管生成，抗增殖和抗肿瘤药。

储存温度：-20°C储存

运输条件：超低温冰袋运输

产品介绍：Regorafenib (BAY 73-4506)是多靶点抑制剂，对VEGFR1，VEGFR2，VEGFR3，PDGFRβ，Kit，RET和Raf-1的IC50分别为13 nM，4.2 nM，46 nMRegorafenib (BAY 73-4506) is a multi-target inhibitor for VEGFR1, VEGFR2, VEGFR3, PDGFRβ, Kit, RET and Raf-1 with IC50 of 13 nM/4.2 nM/46 nM, 22 nM, 7 nM, 1.5 nM and 2.5 nM, respectively.

ALogP：4.2

IUPAC Name：4-[4-[[4-chloro-3-(trifluoromethyl)phenyl]carbamoylamino]-3-fluorophenoxy]-N-methylpyridine-2-carboxamide

INCHI：InChI=1S/C21H15ClF4N4O3/c1-27-19(31)18-10-13(6-7-28-18)33-12-3-5-17(16(23)9-12)30-20(32)29-11-2-4-15(22)14(8-11)21(24,25)26/h2-10H,1H3,(H,27,31)(H2,29,30,32)

InChi Key：FNHKPVJBJVTLMP-UHFFFAOYSA-N

Canonical SMILES：CNC(=O)C1=NC=CC(=C1)OC2=CC(=C(C=C2)NC(=O)NC3=CC(=C(C=C3)Cl)C(F)(F)F)F

Isomeric SMILES：CNC(=O)C1=NC=CC(=C1)OC2=CC(=C(C=C2)NC(=O)NC3=CC(=C(C=C3)Cl)C(F)(F)F)F

PubChem CID：11167602

CAS Registry No.：755037-03-7

ChEMBL Ligand：CHEMBL1946170

ChEBI：CHEBI68647

Wikipedia：Regorafenib

DrugBank Ligand：DB08896

PEP：regorafenib

Reactome Reaction：R-HSA-6802938, R-HSA-9669854, R-HSA-9669900, R-HSA-9674430, R-HSA-9674095, R-HSA-9669870, R-HSA-9674408

Reactome Drug：R-ALL-9657514

DrugCentral Ligand：4654

溶解性：DMSO ≥95mg/mL;Water <1 mg/mL;Ethanol <1 mg/mL

敏感性：对热敏感

熔点：208 °C

象形图：

信号词：Danger

危险声明：H302 Harmful if swallowedH400 Very toxic to aquatic lifeH410 Very toxic to aquatic life with long lasting effectsH372 Causes damage to organs through prolonged or repeated exposureH360 May damage fertility or the unborn childH362 May cause harm to breast-fed children

预防措施声明：P273,P280,P405,P501,P264,P260,P270,P391,P330,P263,P203,P301+P317,P318,P319

产品包装