产品名称

英文名称：Galeterone

同义词

Galeterone、851983-85-2、TOK-001、VN/124-1、Galaterone、TOK 001、VN/124、Galeterone [USAN]、TOK-001(Galeterone)、Tok-001 (galeterone)、VN 124、VN-124-1、WA33E149SW、(3S,8R,9S,10R,13S,14S)-17-(benzimidazol-1-yl)-10,13-dimethyl-2,3,4,7,8,9,11,12,14,15-decahydro-1H-cyclo

产品性质

CAS编号：851983-85-2

分子式：C26H32N2O

分子量：388.56

PubChem编号：11188409

英文别名：Galeterone|851983-85-2|TOK-001|VN/124-1|Galaterone|TOK 001|VN/124|Galeterone [USAN]|TOK-001(Galeterone)|Tok-001 (galeterone)|VN 124|VN-124-1|WA33E149SW|(3S,8R,9S,10R,13S,14S)-17-(benzimidazol-1-yl)-10,13-dimethyl-2,3,4,7,8,9,11,12,14,15-decahydro-1H-cyclo

规格或纯度：≥98%

英文名称：Galeterone

生化机理：CYP17抑制剂（IC50 = 300 nM）和雄激素受体拮抗剂（PC3-AR细胞中IC50 = 384 nM）。在体外抑制DHT刺激的前列腺癌细胞增殖。在携带前列腺癌异种移植物的SCID小鼠中表现出抗肿瘤活性。

储存温度：-20°C储存

运输条件：超低温冰袋运输

备注：卖完停产，不再备货

产品介绍：TOK-001 (VN/124-1; Galeterone)是多功能抗雄激素和CYP17抑制剂，IC50为47 nM。An antagonist to LNCaP ARTOK-001 (VN/124-1; Galeterone) is a multifunctional antiandrogen and CYP17 inhibitor(IC50=47 nM) in castration resistant prostate cancer (CRPC).An antagonist to LNCaP AR

ALogP：5.2

IUPAC Name：(3S,8R,9S,10R,13S,14S)-17-(benzimidazol-1-yl)-10,13-dimethyl-2,3,4,7,8,9,11,12,14,15-decahydro-1H-cyclopenta[a]phenanthren-3-ol

INCHI：InChI=1S/C26H32N2O/c1-25-13-11-18(29)15-17(25)7-8-19-20-9-10-24(26(20,2)14-12-21(19)25)28-16-27-22-5-3-4-6-23(22)28/h3-7,10,16,18-21,29H,8-9,11-15H2,1-2H3/t18-,19-,20-,21-,25-,26-/m0/s1

InChi Key：PAFKTGFSEFKSQG-PAASFTFBSA-N

Canonical SMILES：CC12CCC(CC1=CCC3C2CCC4(C3CC=C4N5C=NC6=CC=CC=C65)C)O

Isomeric SMILES：C[C@]12CC[C@@H](CC1=CC[C@@H]3[C@@H]2CC[C@]4([C@H]3CC=C4N5C=NC6=CC=CC=C65)C)O

PubChem CID：11188409

ChEMBL Ligand：CHEMBL2105738

CAS Registry No.：851983-85-2

Wikipedia：Galeterone

RCSB PDB Ligand：TOK

溶解性：溶于DMSO, 最高浓度 (mg/mL) 19.43, 最高浓度(mM) 50；溶于ethanol, 最高浓度 (mg/mL) 19.43, 最高浓度(mM) 50

象形图：

信号词：Warning

危险声明：H361 Suspected of damaging fertility or the unborn childH371 May cause damage to organsH361fd Suspected of damaging fertility; Suspected of damaging the unborn child

预防措施声明：P280,P405,P501,P264,P260,P270,P203,P318,P308+P316

产品包装