产品名称

英文名称：Ivacaftor (VX-770)

同义词

1134822-00-6 、 GTPL1681 、 N-[2,4-Bis(1,1-dimethylethyl)-5-hydroxyphenyl]-4-oxo-1,4-dihydroquinoline-3-carboxamide 、 3-Quinolinecarboxamide, N-[2,4-bis(1,1-dimethylethyl)-5-hydroxyphenyl]-1,4-dihydro-4-oxo- 、 AC-28324 、 VX-770, Ivacaftor, Kalydeco 、 3-Quin

产品性质

CAS编号：873054-44-5

分子式：C24H28N2O3

分子量：392.49

PubChem编号：16220172

英文别名：1134822-00-6 | GTPL1681 | N-[2,4-Bis(1,1-dimethylethyl)-5-hydroxyphenyl]-4-oxo-1,4-dihydroquinoline-3-carboxamide | 3-Quinolinecarboxamide, N-[2,4-bis(1,1-dimethylethyl)-5-hydroxyphenyl]-1,4-dihydro-4-oxo- | AC-28324 | VX-770, Ivacaftor, Kalydeco | 3-Quin

规格或纯度：≥98%

英文名称：Ivacaftor (VX-770)

生化机理：Ivacaftor is a CFTR activator (IC50 of 43 ± 38 nM). In some cells Ivacaftor was shown to increase CFTR channel open probability in the F508del processing and the G551D gating mutations. In cultured human CF bronchial epithelia (HBE) expressing the F551D gating mutation on one allele and F508del processing mutation on the other allele, Ivacaftor was shown to increase Cl- secretion by about 10-fold, to about 50% of that observed in HBE isolated from individuals without CF, in addition, Ivacaftor reduced excessive Na+ and fluid absorption preventing dehydration of the apical surface and increased cilia beating in these epithelial cultures.

储存温度：-20°C储存

运输条件：超低温冰袋运输

备注：5mg、50mg、10mg卖完停产，不再备货

产品介绍：Ivacaftor (VX-770)是一种囊性纤维化跨膜传导调节器(CFTR)的增强剂，靶向作用于G551D-CFTR和F508del-CFTR，EC50分别为100 nM和25 nM。Is a CFTR activatorIvacaftor (VX-770) is a potentiator of CFTR targeting G551D-CFTR and F508del-CFTR with EC50 of 100 nM and 25 nM, respectively.Is a CFTR activator

ALogP：5.6

IUPAC Name：N-(2,4-ditert-butyl-5-hydroxyphenyl)-4-oxo-1H-quinoline-3-carboxamide

INCHI：InChI=1S/C24H28N2O3/c1-23(2,3)16-11-17(24(4,5)6)20(27)12-19(16)26-22(29)15-13-25-18-10-8-7-9-14(18)21(15)28/h7-13,27H,1-6H3,(H,25,28)(H,26,29)

InChi Key：PURKAOJPTOLRMP-UHFFFAOYSA-N

Canonical SMILES：CC(C)(C)C1=CC(=C(C=C1NC(=O)C2=CNC3=CC=CC=C3C2=O)O)C(C)(C)C

Isomeric SMILES：CC(C)(C)C1=CC(=C(C=C1NC(=O)C2=CNC3=CC=CC=C3C2=O)O)C(C)(C)C

PubChem CID：16220172

ChEBI：CHEBI66901

CAS Registry No.：873054-44-5

Wikipedia：Ivacaftor

ChEMBL Ligand：CHEMBL2010601

DrugBank Ligand：DB08820

PEP：ivacaftor

RCSB PDB Ligand：VX7

Reactome Reaction：R-HSA-5679000, R-HSA-5678992

Reactome Drug：R-ALL-5678956

DrugCentral Ligand：4228

溶解性：DMSO 78 mg/mL Water <1 mg/mL Ethanol <1 mg/mL

象形图：

信号词：Warning

危险声明：H315 Causes skin irritationH319 Causes serious eye irritationH335 May cause respiratory irritationH361 Suspected of damaging fertility or the unborn child

预防措施声明：P261,P305+P351+P338,P280,P302+P352,P321,P405,P501,P264,P271,P304+P340,P403+P233,P362+P364,P203,P264+P265,P318,P337+P317,P332+P317,P319

产品包装