产品名称

英文名称：Stauprimide

同义词

STAUPRIMIDE、154589-96-5、N-Benzoyl-7-oxostaurosporine、7-Oxo-midostaurin、T7R6VV8WUL、N-[(2S,3R,4R,6R)-3-Methoxy-2-methyl-16,18-dioxo-29-oxa-1,7,17-triazaoctacyclo[12.12.2.12,6.07,28.08,13.015,19.020,27.021,26]nonacosa-8,10,12,14,19,21,23,25,27-nonaen-4-yl]-N

产品性质

CAS编号：154589-96-5

分子式：C35H28N4O5

分子量：584.62

PubChem编号：46245328

英文别名：STAUPRIMIDE|154589-96-5|N-Benzoyl-7-oxostaurosporine|7-Oxo-midostaurin|T7R6VV8WUL|N-[(2S,3R,4R,6R)-3-Methoxy-2-methyl-16,18-dioxo-29-oxa-1,7,17-triazaoctacyclo[12.12.2.12,6.07,28.08,13.015,19.020,27.021,26]nonacosa-8,10,12,14,19,21,23,25,27-nonaen-4-yl]-N

规格或纯度：99%

英文名称：Stauprimide

生化机理：引发胚胎干细胞（ESC）分化的小分子。与NME2相互作用并抑制其核易位。提高小鼠和人ESCs体外定向分化的效率。

储存温度：-20°C储存

运输条件：超低温冰袋运输

产品介绍：Stauprimide is an indolocarbazole semi-synthetic small molecule shown to significantly increase the efficiency of directed embryonic stem cell differentiation. Stauprimide inhibits the nuclear localization of NME2, blocking and downregulating c-Myc expression. The expression of c-Myc is crucial for embryonic stem cell self-renewal, and intervention by Stauprimide allows for more efficient lineage-specific differentiation. NME2 is also indicated to be upregulated in certain cancers, indicating further application for the blocking action of StauprimideAn indolocarbazole promoter of embryonic stem cell differentiation.Stauprimide is an indolocarbazole semi-synthetic small molecule shown to significantly increase the efficiency of directed embryonic stem cell differentiation. Stauprimide inhibits the nuclear localization of NME2, blocking and downregulating c-Myc expression. The expression of c-Myc is crucial for embryonic stem cell self-renewal, and intervention by Stauprimide allows for more efficient lineage-specific differentiation. NME2 is also indicated to be upregulated in certain cancers, indicating further application for the blocking action of StauprimideAn indolocarbazole promoter of embryonic stem cell differentiation.

IUPAC Name：N-[(2S,3R,4R,6R)-3-methoxy-2-methyl-16,18-dioxo-29-oxa-1,7,17-triazaoctacyclo[12.12.2.12,6.07,28.08,13.015,19.020,27.021,26]nonacosa-8,10,12,14,19,21,23,25,27-nonaen-4-yl]-N-methylbenzamide

INCHI：InChI=1S/C35H28N4O5/c1-35-31(43-3)23(37(2)34(42)18-11-5-4-6-12-18)17-24(44-35)38-21-15-9-7-13-19(21)25-27-28(33(41)36-32(27)40)26-20-14-8-10-16-22(20)39(35)30(26)29(25)38/h4-16,23-24,31H,17H2,1-3H3,(H,36,40,41)/t23-,24-,31-,35+/m1/s1

InChi Key：MQCCJEYZKWZQHU-MPRCCEKMSA-N

Canonical SMILES：CC12C(C(CC(O1)N3C4=CC=CC=C4C5=C6C(=C7C8=CC=CC=C8N2C7=C53)C(=O)NC6=O)N(C)C(=O)C9=CC=CC=C9)OC

Isomeric SMILES：C[C@@]12[C@@H]([C@@H](C[C@@H](O1)N3C4=CC=CC=C4C5=C6C(=C7C8=CC=CC=C8N2C7=C53)C(=O)NC6=O)N(C)C(=O)C9=CC=CC=C9)OC

WGK Germany：3

PubChem CID：46245328

溶解性：Soluble in DMSO}

敏感性：对光敏感

熔点：145°C

产品包装