产品名称

英文名称：PF-670462

同义词

950912-80-8、PF-670462、PF 670462、PF670462、PF-670462 HCl、D68ANS5I8B、4-(1-cyclohexyl-4-(4-fluorophenyl)-1H-imidazol-5-yl)pyrimidin-2-amine dihydrochloride、4-[1-Cyclohexyl-4-(4-fluorophenyl)-1H-imidazol-5-yl]-2-pyrimidinamine Dihydrochloride、4-[3-cyclohexyl-5

产品性质

CAS编号：950912-80-8

分子式：C19H20FN5·2HCl

分子量：410.32

PubChem编号：51049607

英文别名：950912-80-8|PF-670462|PF 670462|PF670462|PF-670462 HCl|D68ANS5I8B|4-(1-cyclohexyl-4-(4-fluorophenyl)-1H-imidazol-5-yl)pyrimidin-2-amine dihydrochloride|4-[1-Cyclohexyl-4-(4-fluorophenyl)-1H-imidazol-5-yl]-2-pyrimidinamine Dihydrochloride|4-[3-cyclohexyl-5

规格或纯度：≥98%(HPLC)

英文名称：PF-670462

生化机理：PF-670462 is a selective inhibitor of the δ- and ε-isoforms of casein kinase I, with IC50 values of 7.7 and 14 nM respectively, and >30 selectivity relative to 42 other kinases tested. Casein kinase Iε phosphorylates PER proteins, which are involved in setting the period of the circadian pacemaker or clock. PF-670462 is potent (IC50 7.7 nM) and effective in vivo (i.e. it induces profound phase delays in circadian periodicity).Potent, selective casein kinase 1ε (CK1ε) and CK1δ inhibitor (IC 50 values are 7.7 and 14 nM for CK1ε and CK1δ, respectively). Shows >300-fold selectivity over CK2 and selectivity over more than 40 other kinases. Alters circadian rhythms in vivo .

储存温度：2-8°C储存

运输条件：冰袋运输

备注：如果有可能，您尽量在使用的当天配置溶液，并在当天使用完它。但是，如果您需要预先配制储备溶液，我们建议您将溶液等份保存在-20°C的密封小瓶中。通常，它们最多可以使用一个月。在使用前和打开样品瓶之前，我们建议您让您的产品在室温下平衡至少1小时。需要更多关于溶解度，用法和处理的建议吗？请访问我们的常见问题（FAQ）页面以获取更多详细信息。

产品介绍：PF 670462 is a selective casein kinase, CK1ε and CK1δ inhibitor which also shows potency against 42 other kinases. In addition, PF 670462 can inhibit Period circadian protein homolog 1 (PER1) protein nuclear translocation which results in phase shifts in circadian rhythms.A selective CK1ε and CK1δ inhibitor.PF 670462 is a selective casein kinase, CK1ε and CK1δ inhibitor which also shows potency against 42 other kinases. In addition, PF 670462 can inhibit Period circadian protein homolog 1 (PER1) protein nuclear translocation which results in phase shifts in circadian rhythms.A selective CK1ε and CK1δ inhibitor.

IUPAC Name：4-[3-cyclohexyl-5-(4-fluorophenyl)imidazol-4-yl]pyrimidin-2-amine;dihydrochloride

INCHI：InChI=1S/C19H20FN5.2ClH/c20-14-8-6-13(7-9-14)17-18(16-10-11-22-19(21)24-16)25(12-23-17)15-4-2-1-3-5-15;;/h6-12,15H,1-5H2,(H2,21,22,24);2*1H

InChi Key：PSNKGVAXBSAHCH-UHFFFAOYSA-N

Canonical SMILES：C1CCC(CC1)N2C=NC(=C2C3=NC(=NC=C3)N)C4=CC=C(C=C4)F.Cl.Cl

Isomeric SMILES：C1CCC(CC1)N2C=NC(=C2C3=NC(=NC=C3)N)C4=CC=C(C=C4)F.Cl.Cl

WGK Germany：3

PubChem CID：51049607

溶解性：Soluble in water (100 mM), and DMSO (100 mM).

敏感性：对湿度敏感

产品包装