产品名称

英文名称：Pracinostat (SB939)

同义词

Pracinostat、929016-96-6、SB939、SB 939、Pracinostat (SB939)、SB-939、Pracinostat [INN]、(E)-3-(2-butyl-1-(2-(diethylamino)ethyl)-1H-benzo[d]imidazol-5-yl)-N-hydroxyacrylamide、Pracinostat(SB939)、GPO2JN4UON、CHEMBL1851943、2-Propenamide, 3-(2-butyl-1-(2-(diethylami

产品性质

CAS编号：929016-96-6

分子式：C20H30N4O2

分子量：358.48

PubChem编号：49855250

英文别名：Pracinostat|929016-96-6|SB939|SB 939|Pracinostat (SB939)|SB-939|Pracinostat [INN]|(E)-3-(2-butyl-1-(2-(diethylamino)ethyl)-1H-benzo[d]imidazol-5-yl)-N-hydroxyacrylamide|Pracinostat(SB939)|GPO2JN4UON|CHEMBL1851943|2-Propenamide, 3-(2-butyl-1-(2-(diethylami

规格或纯度：≥98%

英文名称：Pracinostat (SB939)

生化机理：SB939 is a potent inhibitor of HDAC class I and II isoenzymes, HDAC1, HDAC2, HDAC3 HDAC4, HDAC5, HDAC7, HDAC8, HDAC9 and HDAC10 with the IC50 values ranging from 43 nM to 140 nM. HDAC6 shows an IC50 of 1008 nM. It markedly inhibits HDAC11 of the HDAC class IV enzymes with an IC50 of 93 nM. SB939 shows significant anti-proliferative activity against a wide variety of tumor cell lines, especially Leukemia cells and cutaneous T-cell Lymphoma cells with IC50 values ranging from 50 nM (H9 cells) to 170 nM (HEL92.1.7 cells).Potent HDAC inhibitor (IC 50 = 77 nM, HDAC1). Shows antiproliferative effects in cancer cell lines (IC 50 values are 480, 560, 480, and 340 nM for A2780, COLO 205 and HCT-116 and PC-3 lines respectively). Shows antitumor and potent antimalarial effects in

储存温度：-20°C储存

运输条件：超低温冰袋运输

备注：如果有可能，您尽量在使用的当天配置溶液，并在当天使用完它。但是，如果您需要预先配制储备溶液，我们建议您将溶液等份保存在-20°C的密封小瓶中。通常，它们最多可以使用一个月。在使用前和打开样品瓶之前，我们建议您让您的产品在室温下平衡至少1小时。需要更多关于溶解度，用法和处理的建议吗？请访问我们的常见问题（FAQ）页面以获取更多详细信息。

产品介绍：Pracinostat (SB939)是一种有效的pan-HDAC抑制剂，IC50为40-140 nM，除了HDAC6例外，对III型同工酶SIRT I没有抑制活性。A non-selective inhibitor of HDAC.Pracinostat (SB939) is a potent pan-HDAC inhibitor with IC50 of 40-140 nM with exception for HDAC6. It has no activity against the class III isoenzyme SIRT I.A non-selective inhibitor of HDAC.

IUPAC Name：(E)-3-[2-butyl-1-[2-(diethylamino)ethyl]benzimidazol-5-yl]-N-hydroxyprop-2-enamide

INCHI：InChI=1S/C20H30N4O2/c1-4-7-8-19-21-17-15-16(10-12-20(25)22-26)9-11-18(17)24(19)14-13-23(5-2)6-3/h9-12,15,26H,4-8,13-14H2,1-3H3,(H,22,25)/b12-10+

InChi Key：JHDKZFFAIZKUCU-ZRDIBKRKSA-N

Canonical SMILES：CCCCC1=NC2=C(N1CCN(CC)CC)C=CC(=C2)C=CC(=O)NO

Isomeric SMILES：CCCCC1=NC2=C(N1CCN(CC)CC)C=CC(=C2)/C=C/C(=O)NO

PubChem CID：49855250

CAS Registry No.：929016-96-6

ChEMBL Ligand：CHEMBL1851943

Wikipedia：Pracinostat

溶解性：DMSO ≥70mg/mL Water <1.2mg/mL Ethanol ≥70mg/mL

产品包装