产品名称

英文名称：CAL-101

同义词

Idelalisib、870281-82-6、CAL-101、Zydelig、GS-1101、CAL101、CAL 101、(S)-2-(1-((9H-Purin-6-yl)amino)propyl)-5-fluoro-3-phenylquinazolin-4(3H)-one、1146702-54-6、Idelalisib (CAL-101)、UNII-YG57I8T5M0、CAL-101 (Idelalisib, GS-1101)、GS 1101、YG57I8T5M0、CHEBI82701、5-Flu

产品性质

CAS编号：870281-82-6

分子式：C22H18FN7O

分子量：415.43

PubChem编号：11625818

英文别名：Idelalisib|870281-82-6|CAL-101|Zydelig|GS-1101|CAL101|CAL 101|(S)-2-(1-((9H-Purin-6-yl)amino)propyl)-5-fluoro-3-phenylquinazolin-4(3H)-one|1146702-54-6|Idelalisib (CAL-101)|UNII-YG57I8T5M0|CAL-101 (Idelalisib, GS-1101)|GS 1101|YG57I8T5M0|CHEBI82701|5-Flu

规格或纯度：≥99%

英文名称：CAL-101

生化机理：CAL-101 (GS-1101) is a potent and selective PI3K p110δ inhibitor with an IC50 of 2.5 nM. This compound induces selective cytotoxicity in CLL cells and is independent of IgVH mutational status. CAL--101 also acts as an antagonist in CD40L-mediated CLL cell survival.

储存温度：-20°C储存

运输条件：超低温冰袋运输

备注：10mg卖完停产，不再备货

产品介绍：CAL-101 (Idelalisib, GS-1101)是一种选择性p110δ抑制剂，IC50为2.5 nM；作用于p110δ比作用于p110α/β/γ选择性高40到300倍，作用于p110δ比作用于C2β， hVPS34， DNA-PK和mTOR选择性高400到4000倍。Phase 3。A potent PI3K p110δ inhibitorCAL-101 (Idelalisib, GS-1101) is a selective p110δ inhibitor with IC50 of 2.5 nM; shown to have 40- to 300-fold greater selectivity for p110δ thanp110α/β/γ, and 400- to 4000-fold more selectivity to p110δ than C2β, hVPS34, DNA-PK and mTOR.A potent PI3K p110δ inhibitor

ALogP：3.7

IUPAC Name：5-fluoro-3-phenyl-2-[(1S)-1-(7H-purin-6-ylamino)propyl]quinazolin-4-one

INCHI：InChI=1S/C22H18FN7O/c1-2-15(28-20-18-19(25-11-24-18)26-12-27-20)21-29-16-10-6-9-14(23)17(16)22(31)30(21)13-7-4-3-5-8-13/h3-12,15H,2H2,1H3,(H2,24,25,26,27,28)/t15-/m0/s1

InChi Key：IFSDAJWBUCMOAH-HNNXBMFYSA-N

Canonical SMILES：CCC(C1=NC2=C(C(=CC=C2)F)C(=O)N1C3=CC=CC=C3)NC4=NC=NC5=C4NC=N5

Isomeric SMILES：CC[C@@H](C1=NC2=C(C(=CC=C2)F)C(=O)N1C3=CC=CC=C3)NC4=NC=NC5=C4NC=N5

PubChem CID：11625818

CAS Registry No.：870281-82-6

ChEMBL Ligand：CHEMBL2216870

Wikipedia：Idelalisib

RCSB PDB Ligand：40L

PEP：idelalisib

DrugCentral Ligand：4878

溶解性：DMSO 83 mg/mL Water <1 mg/mL Ethanol 35 mg/mL

象形图：

信号词：Danger

危险声明：H372 Causes damage to organs through prolonged or repeated exposureH360 May damage fertility or the unborn child

预防措施声明：P280,P405,P501,P264,P260,P270,P203,P318,P319

产品包装