产品名称

英文名称：Tubastatin A HCl

同义词

BCP02887、4-((2-Methyl-3,4-dihydro-1H-pyrido(4,3-b)indol-5-yl)methyl)benzenecarbohydroxamic acid hydrochloride、N-hydroxy-4-[(2-methyl-3,4-dihydro-1H-pyrido[4,3-b]indol-5-yl)methyl]benzamide;hydrochloride、TSA HCl、UNII-UHCM2AYJVX、CCG-268318、SW219287-1、Tubast、Tubastatin A 盐酸盐

产品性质

CAS编号：1310693-92-5

分子式：C20H21N3O2.HCl

分子量：371.86

MDL号：MFCD20488052

PubChem编号：57336514

别名：Tubastatin A 盐酸盐

英文别名：BCP02887|4-((2-Methyl-3,4-dihydro-1H-pyrido(4,3-b)indol-5-yl)methyl)benzenecarbohydroxamic acid hydrochloride|N-hydroxy-4-[(2-methyl-3,4-dihydro-1H-pyrido[4,3-b]indol-5-yl)methyl]benzamide;hydrochloride|TSA HCl|UNII-UHCM2AYJVX|CCG-268318|SW219287-1|Tubast

规格或纯度：≥98%

英文名称：Tubastatin A HCl

生化机理：高效的HDAC6抑制剂（IC50 = 0.015μM）。在HDAC8和HDAC8上选择性展示一些HDAC6（IC50值分别为0.854和16.4μM）。在原代神经元细胞培养物中诱导高水平的α-微管蛋白并防止谷胱甘肽诱导的氧化应激。在Charcot-Marie-Tooth病小鼠模型中逆转周围神经元的轴突丧失。

应用：An HDAC6 inhibitor

储存温度：-20°C储存

运输条件：超低温冰袋运输

产品介绍：Tubastatin A盐酸盐是HDAC6选择性抑制剂，IC50为15 nM，比对其它亚型的抑制性高1000倍（相对HDAC8是57倍）。An HDAC6 inhibitorTubastatin A HCl is a potent and selective HDAC6 inhibitor with IC50 of 15 nM in a cell-free assay. It is selective (1000-fold more) against all other isozymes except HDAC8 (57-fold more).An HDAC6 inhibitor

IUPAC Name：N-hydroxy-4-[(2-methyl-3,4-dihydro-1H-pyrido[4,3-b]indol-5-yl)methyl]benzamide;hydrochloride

INCHI：InChI=1S/C20H21N3O2.ClH/c1-22-11-10-19-17(13-22)16-4-2-3-5-18(16)23(19)12-14-6-8-15(9-7-14)20(24)21-25;/h2-9,25H,10-13H2,1H3,(H,21,24);1H

InChi Key：LJTSJTWIMOGKRJ-UHFFFAOYSA-N

Canonical SMILES：CN1CCC2=C(C1)C3=CC=CC=C3N2CC4=CC=C(C=C4)C(=O)NO.Cl

Isomeric SMILES：CN1CCC2=C(C1)C3=CC=CC=C3N2CC4=CC=C(C=C4)C(=O)NO.Cl

PubChem CID：57336514

溶解性：溶于DMSO, 最高浓度 (mg/mL) 3.72, 最高浓度(mM) 10 温和加热

敏感性：对热敏感

产品包装