产品名称

英文名称：Belinostat (PXD101)

同义词

Belinostat、414864-00-9、PXD101、866323-14-0、Belinostat (PXD101)、Beleodaq、PXD-101、(E)-N-hydroxy-3-(3-(N-phenylsulfamoyl)phenyl)acrylamide、E-Belinostat、NSC726630、PXD 101、PX-105684、N-HYDROXY-3-(3-PHENYLSULFAMOYLPHENYL)ACRYLAMIDE、UNII-F4H96P17NZ、F4H96P17NZ、PX10

产品性质

CAS编号：414864-00-9

分子式：C15H14N2O4S

分子量：318.35

PubChem编号：6918638

英文别名：Belinostat|414864-00-9|PXD101|866323-14-0|Belinostat (PXD101)|Beleodaq|PXD-101|(E)-N-hydroxy-3-(3-(N-phenylsulfamoyl)phenyl)acrylamide|E-Belinostat|NSC726630|PXD 101|PX-105684|N-HYDROXY-3-(3-PHENYLSULFAMOYLPHENYL)ACRYLAMIDE|UNII-F4H96P17NZ|F4H96P17NZ|PX10

规格或纯度：≥98%

英文名称：Belinostat (PXD101)

生化机理：Belinostat (PXD101) is a novel HDAC inhibitor with IC50 of 27 nM. Belinostat inhibits the growth of tumor cells (A2780, HCT116, HT29, WIL, CALU-3, MCF7, PC3 and HS852) with IC50 from 0.2-0.66 μM. PD101 shows low activity in A2780/cp70 and 2780AD cells. Belinostat inhibits bladder cancer cell growth, especially in 5637 cells, which shows accumulation of G0-G1 phase, decrease in S phase, and increase in G2-M phase. Belinostat also shows enhanced tubulin acetylation in ovarian cancer cell lines. A recent study shows that Belinostat activates protein kinase A in a TGF-β signaling-dependent mechanism and decreases survivin mRNA.

储存温度：-20°C储存

运输条件：超低温冰袋运输

备注：卖完停产，不再备货

产品介绍：Belinostat (PXD101)是一种新型的HDAC抑制剂，IC50为27 nM，对抵抗Cisplatin的肿瘤有效。一种新型HDAC抑制剂Belinostat (PXD101) is a novel HDAC inhibitor with IC50 of 27 nM, with activity demonstrated in cisplatin-resistant tumors.A novel HDAC inhibitor

ALogP：1.7

IUPAC Name：(E)-N-hydroxy-3-[3-(phenylsulfamoyl)phenyl]prop-2-enamide

INCHI：InChI=1S/C15H14N2O4S/c18-15(16-19)10-9-12-5-4-8-14(11-12)22(20,21)17-13-6-2-1-3-7-13/h1-11,17,19H,(H,16,18)/b10-9+

InChi Key：NCNRHFGMJRPRSK-MDZDMXLPSA-N

Canonical SMILES：C1=CC=C(C=C1)NS(=O)(=O)C2=CC=CC(=C2)C=CC(=O)NO

Isomeric SMILES：C1=CC=C(C=C1)NS(=O)(=O)C2=CC=CC(=C2)/C=C/C(=O)NO

PubChem CID：6918638

ChEMBL Ligand：CHEMBL408513

ChEBI：CHEBI61076

Wikipedia：Belinostat

CAS Registry No.：414864-00-9

DrugBank Ligand：DB05015

RCSB PDB Ligand：5OG

PEP：belinostat

Reactome Reaction：R-HSA-9679787

Reactome Drug：R-ALL-9679789

溶解性：DMSO 64 mg/mL Water <1 mg/mL Ethanol <1 mg/mL

产品包装