产品名称

英文名称：BMS-265246

同义词

BMS-265246、582315-72-8、BMS265246、BMS 265246、(4-butoxy-1H-pyrazolo[3,4-b]pyridin-5-yl)-(2,6-difluoro-4-methylphenyl)methanone、CHEMBL310840、(4-butoxy-1H-pyrazolo[3,4-b]pyridin-5-yl)(2,6-difluoro-4-methylphenyl)methanone、MLS006011031、BDBM5776、SCHEMBL15757461

产品性质

CAS编号：582315-72-8

分子式：C18H17F2N3O2

分子量：345.34

PubChem编号：135402864

英文别名：BMS-265246|582315-72-8|BMS265246|BMS 265246|(4-butoxy-1H-pyrazolo[3,4-b]pyridin-5-yl)-(2,6-difluoro-4-methylphenyl)methanone|CHEMBL310840|(4-butoxy-1H-pyrazolo[3,4-b]pyridin-5-yl)(2,6-difluoro-4-methylphenyl)methanone|MLS006011031|BDBM5776|SCHEMBL15757461

规格或纯度：95%

英文名称：BMS-265246

生化机理：强大的细胞周期蛋白依赖性激酶1（cdk1）和cdk 2抑制剂（IC50值分别为5.6-71和6-14 nM）。还抑制亚 微摩尔范围内的cdk4和cdk5以及低微摩尔范围内的cdk7和cdk9。在体外抑制HCT-116结肠癌细胞的增殖。BMS-265246 is an ATP site-targeting, potent and CDK1/2-selective cyclin-dependent kinase inhibitor (IC50 = 6 nM/CDK1, 9 nM/CDK2, 230 nM/CDK4) with anti-cancer efficacy in A2780 ovarian cancer culture (IC50 = 760 nM).

储存温度：-20°C储存

运输条件：超低温冰袋运输

产品介绍：BMS-265246是一种有效的选择性CDK1/2抑制剂，无细胞试验中IC50为6 nM/9 nM。作用于CDK1/2 比作用于CDK4选择性高25倍。

IUPAC Name：(4-butoxy-2H-pyrazolo[3,4-b]pyridin-5-yl)-(2,6-difluoro-4-methylphenyl)methanone

INCHI：InChI=1S/C18H17F2N3O2/c1-3-4-5-25-17-11(8-21-18-12(17)9-22-23-18)16(24)15-13(19)6-10(2)7-14(15)20/h6-9H,3-5H2,1-2H3,(H,21,22,23)

InChi Key：SCFMWQIQBVZOQR-UHFFFAOYSA-N

Canonical SMILES：CCCCOC1=C(C=NC2=NNC=C12)C(=O)C3=C(C=C(C=C3F)C)F

Isomeric SMILES：CCCCOC1=C(C=NC2=NNC=C12)C(=O)C3=C(C=C(C=C3F)C)F

PubChem CID：135402864

CAS Registry No.：582315-72-8

ChEMBL Ligand：CHEMBL310840

溶解性：溶于DMSO, 最高浓度 (mg/mL) 17.27, 最高浓度(mM) 50

产品包装