产品名称

英文名称：EBE-A22

同义词

EBE-A22、229476-53-3、N-(3-bromophenyl)-6,7-dimethoxy-N-methylquinazolin-4-amine、CHEMBL447230、4-Quinazolinamine, N-(3-bromophenyl)-6,7-dimethoxy-N-methyl-、BDBM3563、DTXSID60416148、BCP20742、s6530、AKOS030526739、CS-1603、EBE-A 22;EBE A22; EBEA22、HY-14347、MS-2603

产品性质

CAS编号：229476-53-3

分子式：C17H16BrN3O2

分子量：374.23

PubChem编号：5328227

英文别名：EBE-A22|229476-53-3|N-(3-bromophenyl)-6,7-dimethoxy-N-methylquinazolin-4-amine|CHEMBL447230|4-Quinazolinamine, N-(3-bromophenyl)-6,7-dimethoxy-N-methyl-|BDBM3563|DTXSID60416148|BCP20742|s6530|AKOS030526739|CS-1603|EBE-A 22;EBE A22; EBEA22|HY-14347|MS-2603

规格或纯度：98%

英文名称：EBE-A22

生化机理：DescriptionEBE-A22 is a derivative of PD 153035 which can inhibit ErbB-1-phosphorylation, whereas EBE-A22 is inactive. The brominated anilinoquinazoline derivative PD153035 exhibits a very high affinity and selectivity for the epidermal growth factor receptor tyrosine kinase (EGF-R TK) and shows a remarkable cytotoxicity against several types of tumor cell lines. In contrast, its N-methyl derivative, designated EBE-A22, has no effect on EGF-R TK but maintains a high cytotoxic profile. The present study was performed to explore the possibility that PD153035 and its N-methyl analogue might interact with double-stranded DNA, which is a primary target for many conventional antitumor agents. We studied the strength and mode of binding to DNA of PD153035 and EBE-A22 by means of absorption, fluorescence, and circular and linear dichroism as well as by a relaxation assay using human DNA topoisomerases. The results of various optical and gel electrophoresis techniques co

储存温度：-20°C储存

运输条件：超低温冰袋运输

IUPAC Name：N-(3-bromophenyl)-6,7-dimethoxy-N-methylquinazolin-4-amine

INCHI：InChI=1S/C17H16BrN3O2/c1-21(12-6-4-5-11(18)7-12)17-13-8-15(22-2)16(23-3)9-14(13)19-10-20-17/h4-10H,1-3H3

InChi Key：IPWGDOZPSOZFOD-UHFFFAOYSA-N

Canonical SMILES：CN(C1=CC(=CC=C1)Br)C2=NC=NC3=CC(=C(C=C32)OC)OC

Isomeric SMILES：CN(C1=CC(=CC=C1)Br)C2=NC=NC3=CC(=C(C=C32)OC)OC

PubChem CID：5328227

溶解性：soluble in DMSO.

产品包装