产品名称

英文名称：Lesinurad

同义词

{[5-bromo-4-(4-cyclopropylnaphthalen-1-yl)-4H-1,2,4-triazol-3-yl]sulfanyl}acetic acid、2-((5-bromo-4-(4-cyclopropylnaphthalen-1-yl)-4H-1,2,4-triazol-3-yl)thio)acetic acid、AS-56014、RDEA594、RDEA-594、UNII-73WY698HZ7、(5-bromo-4-(1-cyclopropylnaphthalen-4-yl)-4、雷西纳德

产品性质

CAS编号：878672-00-5

分子式：C17H14BrN3O2S

分子量：404.28

PubChem编号：53465279

别名：雷西纳德

英文别名：{[5-bromo-4-(4-cyclopropylnaphthalen-1-yl)-4H-1,2,4-triazol-3-yl]sulfanyl}acetic acid|2-((5-bromo-4-(4-cyclopropylnaphthalen-1-yl)-4H-1,2,4-triazol-3-yl)thio)acetic acid|AS-56014|RDEA594|RDEA-594|UNII-73WY698HZ7|(5-bromo-4-(1-cyclopropylnaphthalen-4-yl)-4

规格或纯度：98%

英文名称：Lesinurad

生化机理：Lesinurad is a selective inhibitor of Urate transporter 1 (URAT1), a urate-anion exchanger which is responsible for the majority of uric acid reabsorption from the renal tubular lumen. Lesinurad thus reduces serum uric acid levels. Lesinurad has been approved for use in combination with a xanthine oxidase inhibitor to treat hyperuricemia associated with gout.

储存温度：-20°C储存

运输条件：超低温冰袋运输

备注：5mg、50mg、10mg卖完停产，不再备货

产品介绍：Lesinurad(RDEA594)是URAT1抑制剂，可调节尿酸分泌。Lesinurad(RDEA594), once-daily inhibitor of URAT1, is a transporter in the kidney that regulates uric acid excretion from the body.

ALogP：4.7

PubChem SID：488201641

PubChem SID url：https//pubchem.ncbi.nlm.nih.gov/substance/488201641

IUPAC Name：2-[[5-bromo-4-(4-cyclopropylnaphthalen-1-yl)-1,2,4-triazol-3-yl]sulfanyl]acetic acid

INCHI：InChI=1S/C17H14BrN3O2S/c18-16-19-20-17(24-9-15(22)23)21(16)14-8-7-11(10-5-6-10)12-3-1-2-4-13(12)14/h1-4,7-8,10H,5-6,9H2,(H,22,23)

InChi Key：FGQFOYHRJSUHMR-UHFFFAOYSA-N

Canonical SMILES：C1CC1C2=CC=C(C3=CC=CC=C23)N4C(=NN=C4Br)SCC(=O)O

Isomeric SMILES：C1CC1C2=CC=C(C3=CC=CC=C23)N4C(=NN=C4Br)SCC(=O)O

PubChem CID：53465279

CAS Registry No.：878672-00-5

ChEMBL Ligand：CHEMBL2105720

DrugCentral Ligand：5075

溶解性：25°C DMSO

象形图：

信号词：Warning

危险声明：H302 Harmful if swallowed

预防措施声明：P501,P264,P270,P330,P301+P317

产品包装