产品名称

英文名称：IOX2

同义词

IOX2、931398-72-0、IOX 2、2-(1-benzyl-4-hydroxy-2-oxo-1,2-dihydroquinoline-3-carboxamido)acetic acid、CHEMBL3186774、2-[(1-benzyl-4-hydroxy-2-oxoquinoline-3-carbonyl)amino]acetic acid、N-[[1,2-Dihydro-4-hydroxy-2-oxo-1-(phenylmethyl)-3-quinolinyl]carbonyl]glyci

产品性质

CAS编号：931398-72-0

分子式：C19H16N2O5

分子量：352.34

PubChem编号：54685215

英文别名：IOX2|931398-72-0|IOX 2|2-(1-benzyl-4-hydroxy-2-oxo-1,2-dihydroquinoline-3-carboxamido)acetic acid|CHEMBL3186774|2-[(1-benzyl-4-hydroxy-2-oxoquinoline-3-carbonyl)amino]acetic acid|N-[[1,2-Dihydro-4-hydroxy-2-oxo-1-(phenylmethyl)-3-quinolinyl]carbonyl]glyci

规格或纯度：≥98%

英文名称：IOX2

生化机理：IOX2 is selective and potent inhibitor of prolyl hydroxylases (PHD). Stabilization of HIF-1R throμgh inhibition of PHD has been examined as a potential treatment for ischemic diseases including anemia, myocardial infarction, and stroke. IOX2 is a selective inhibitor of the hypoxia inducible factor (HIF) prolyl-hydroxylases (PHD) that exhibits up-regulation of HIF1a in zebrafish.Potent, cell-permeable, selective HIF-1 α prolyl hydroxylase-2 (PHD2) inhibitor (IC 50 = 21 nM). Displays over 100-fold selectivity for PHD2 over factor inhibiting HIF-1 (FIH-1) and histone demethylases JMJD2A, JMJD2C, JMJD2E and JMJD3.

储存温度：2-8°C储存

运输条件：冰袋运输

备注：有毒，请参阅SDS以获取更多信息。需要更多关于溶解度，用法和处理的建议吗？请访问我们的常见问题（FAQ）页面以获取更多详细信息。

产品介绍：IOX2是低氧诱导因子（HIF）脯氨酰羟化酶（PHD）抑制剂，在细胞中对PHD2/ELGN-1的IC50为21 nM，对FIH无活性。IOX2 is a potent inhibitor of HIF-1α prolyl hydroxylase-2 (PHD2) with IC50 of 21 nM in a cell-free assay, >100-fold selectivity over JMJD2A, JMJD2C, JMJD2E, JMJD3, or the 2OG oxygenase FIH.

IUPAC Name：2-[(1-benzyl-4-hydroxy-2-oxoquinoline-3-carbonyl)amino]acetic acid

INCHI：InChI=1S/C19H16N2O5/c22-15(23)10-20-18(25)16-17(24)13-8-4-5-9-14(13)21(19(16)26)11-12-6-2-1-3-7-12/h1-9,24H,10-11H2,(H,20,25)(H,22,23)

InChi Key：CAOSCCRYLYQBES-UHFFFAOYSA-N

Canonical SMILES：C1=CC=C(C=C1)CN2C3=CC=CC=C3C(=C(C2=O)C(=O)NCC(=O)O)O

Isomeric SMILES：C1=CC=C(C=C1)CN2C3=CC=CC=C3C(=C(C2=O)C(=O)NCC(=O)O)O

WGK Germany：3

PubChem CID：54685215

CAS Registry No.：931398-72-0

ChEMBL Ligand：CHEMBL3186774

溶解性：DMSO 100 mg/ml

象形图：

信号词：Danger

危险声明：H301 Toxic if swallowed

预防措施声明：P321,P405,P501,P264,P270,P330,P301+P316

产品包装