产品名称

英文名称：AZ20

同义词

AZ20、1233339-22-4、AZ 20、(3R)-4-[2-(1H-indol-4-yl)-6-(1-methylsulfonylcyclopropyl)pyrimidin-4-yl]-3-methylmorpholine、(R)-4-(2-(1H-indol-4-yl)-6-(1-(methylsulfonyl)cyclopropyl)pyrimidin-4-yl)-3-methylmorpholine、CHEMBL2325697、4-[4-(1-methanesulfonylcycloprop、4-[4-[(3R)-3-甲基-4-吗啉基]-6-[1-(甲基磺酰基)环丙基]-2-嘧啶基]-1H-吲哚

产品性质

CAS编号：1233339-22-4

分子式：C21H24N4O3S

分子量：412.51

PubChem编号：46244454

别名：4-[4-[(3R)-3-甲基-4-吗啉基]-6-[1-(甲基磺酰基)环丙基]-2-嘧啶基]-1H-吲哚

英文别名：AZ20|1233339-22-4|AZ 20|(3R)-4-[2-(1H-indol-4-yl)-6-(1-methylsulfonylcyclopropyl)pyrimidin-4-yl]-3-methylmorpholine|(R)-4-(2-(1H-indol-4-yl)-6-(1-(methylsulfonyl)cyclopropyl)pyrimidin-4-yl)-3-methylmorpholine|CHEMBL2325697|4-[4-(1-methanesulfonylcycloprop

规格或纯度：≥98%

英文名称：AZ20

生化机理：DescriptionIC50 Value 5nM [1]AZ20 is a potent and selective inhibitor of ATR with an IC50 value of 5 nM. AZ20 was discovered from a lead discovery and early optimization campaign from an mTOR inhibitor screening hit.in vitro AZ20 decreases pChk1 Ser345, pChk1 Ser317 and pChk1 Ser296 levels in a concentration-dependent manner. Prolonged exposure with AZ20 increases H2AX pan-nuclear staining, indicative of replication stress [2].in vivo AZ20 induces significant tumour growth inhibition in vivo at well tolerated doses [2].Clinical trial N/A.Potent and selective ATR kinase inhibitor (IC 50 = 5 nM in vitro ; IC 50 = 50 nM in carcinoma cell lines). Selective versus mTOR (8-fold). Displayed selectivity versus a panel of 442 kinases.Inhibits\xa0LoVo colorectal adenocarcinoma tumor cell growth.

储存温度：-20°C储存

运输条件：超低温冰袋运输

备注：有关更多信息，请参考SDS。需要更多关于溶解度，用法和处理的建议吗？请访问我们的常见问题（FAQ）页面以获取更多详细信息。

IUPAC Name：(3R)-4-[2-(1H-indol-4-yl)-6-(1-methylsulfonylcyclopropyl)pyrimidin-4-yl]-3-methylmorpholine

INCHI：InChI=1S/C21H24N4O3S/c1-14-13-28-11-10-25(14)19-12-18(21(7-8-21)29(2,26)27)23-20(24-19)16-4-3-5-17-15(16)6-9-22-17/h3-6,9,12,14,22H,7-8,10-11,13H2,1-2H3/t14-/m1/s1

InChi Key：SCGCBAAYLFTIJU-CQSZACIVSA-N

Canonical SMILES：CC1COCCN1C2=NC(=NC(=C2)C3(CC3)S(=O)(=O)C)C4=C5C=CNC5=CC=C4

Isomeric SMILES：C[C@@H]1COCCN1C2=NC(=NC(=C2)C3(CC3)S(=O)(=O)C)C4=C5C=CNC5=CC=C4

PubChem CID：46244454

ChEMBL Ligand：CHEMBL2325697

CAS Registry No.：1233339-22-4

RCSB PDB Ligand：VCD

溶解性：25°C DMSO

象形图：

信号词：Warning

危险声明：H302 Harmful if swallowed

预防措施声明：P501,P264,P270,P330,P301+P317

产品包装