产品名称

英文名称：KPT-185

同义词

KPT185; KPT 185;(2Z)-3-[3-[3-Methoxy-5-(trifluoromethyl)phenyl]-1H-1,2,4-triazol-1-yl]-2-Propenoic Acid 1-Methylethyl Ester、KPT185

产品性质

CAS编号：1333151-73-7

分子式：C16H16F3N3O3

分子量：355.31

PubChem编号：53495165

别名：KPT185

英文别名：KPT185; KPT 185;(2Z)-3-[3-[3-Methoxy-5-(trifluoromethyl)phenyl]-1H-1,2,4-triazol-1-yl]-2-Propenoic Acid 1-Methylethyl Ester

规格或纯度：≥98%

英文名称：KPT-185

生化机理：KPT 185 is an orally bioavailable selective inhibitor of CRM1 amd displayes potent antiproliferatve properties at submicromolar concentrations (IC50 values100-500nM), induced apoptosis (average5-fold increase), cell-cycle arrest, and myeloid differentiation in AML cell lines and patient blasts.

储存温度：-20°C储存

运输条件：超低温冰袋运输

备注：10mg卖完停产，不再备货

产品介绍：KPT-185是一种选择性的CRM1抑制剂。KPT-185 is a selective CRM1 inhibitor.

IUPAC Name：propan-2-yl (Z)-3-[3-[3-methoxy-5-(trifluoromethyl)phenyl]-1,2,4-triazol-1-yl]prop-2-enoate

INCHI：InChI=1S/C16H16F3N3O3/c1-10(2)25-14(23)4-5-22-9-20-15(21-22)11-6-12(16(17,18)19)8-13(7-11)24-3/h4-10H,1-3H3/b5-4-

InChi Key：NLNGWFLRRRYNIL-PLNGDYQASA-N

Canonical SMILES：CC(C)OC(=O)C=CN1C=NC(=N1)C2=CC(=CC(=C2)OC)C(F)(F)F

Isomeric SMILES：CC(C)OC(=O)/C=C\N1C=NC(=N1)C2=CC(=CC(=C2)OC)C(F)(F)F

PubChem CID：53495165

溶解性：DMSO 71 mg/mL Water Ethanol 71 mg/mL

产品包装