产品名称

英文名称：AZD3463

同义词

1356962-20-3、AZD3463、AZD-3463、N-(4-(4-Aminopiperidin-1-yl)-2-methoxyphenyl)-5-chloro-4-(1H-indol-3-yl)pyrimidin-2-amine、ALK/IGF1R inhibitor、N-[4-(4-aminopiperidin-1-yl)-2-methoxyphenyl]-5-chloro-4-(1H-indol-3-yl)pyrimidin-2-amine、CS-1382、HY-15609、N-(4-(4-

产品性质

CAS编号：1356962-20-3

分子式：C24H25ClN6O

分子量：448.95

PubChem编号：56599293

英文别名：1356962-20-3|AZD3463|AZD-3463|N-(4-(4-Aminopiperidin-1-yl)-2-methoxyphenyl)-5-chloro-4-(1H-indol-3-yl)pyrimidin-2-amine|ALK/IGF1R inhibitor|N-[4-(4-aminopiperidin-1-yl)-2-methoxyphenyl]-5-chloro-4-(1H-indol-3-yl)pyrimidin-2-amine|CS-1382|HY-15609|N-(4-(4-

规格或纯度：≥98%

英文名称：AZD3463

生化机理：AZD-3463 is an ALK/IGF1R inhibitor which overcomes multiple mechanisms of acquired resistance to crizotinib.AZD3463 is an orally available, potent receptor tyrosine kinase (RTK) inhibtor against anaplastic lymphoma kinase ALK (Ki = 0.75 nM; IC50 = 15-21 nM with 5FAM-Srctide as substrate & 30 μM ATP), insulin-like growth factor (IGF)-1 receptor (IGF1R), ROS1 (c-Ros), and Trk-A (NTRK1). AZD3463 effectively inhibits multiple crizotinib-resistant cancer growth and displays in vivo efficacy against FLT3-ITD-dependent MOLM-13 acute myeloid leukemia (AML) as well as NGP (wt ALK) & SH-SY5Y (ALK-F1174L) neuroblastoma in mice (15 mg/kg ip.).

储存温度：-20°C储存

运输条件：超低温冰袋运输

产品介绍：AZD-3463是ALK/IGF1R抑制剂。产品介绍AZD-3463 (ALK/IGF1R inhibitor) 是一种ALK/IGF1R 抑制剂，对 ALK 作用的 Ki 值为 0.75 nM。AZD-3463 可诱导神经母细胞瘤细胞凋亡 (apoptosis) 和自噬 (autophagy)。AZD3463 is a novel orally bioavailable ALK inhibitor with Ki of 0.75 nM, which also inhibits IGF1R with equivalent potency.

IUPAC Name：N-[4-(4-aminopiperidin-1-yl)-2-methoxyphenyl]-5-chloro-4-(1H-indol-3-yl)pyrimidin-2-amine

INCHI：InChI=1S/C24H25ClN6O/c1-32-22-12-16(31-10-8-15(26)9-11-31)6-7-21(22)29-24-28-14-19(25)23(30-24)18-13-27-20-5-3-2-4-17(18)20/h2-7,12-15,27H,8-11,26H2,1H3,(H,28,29,30)

InChi Key：GCYIGMXOIWJGBU-UHFFFAOYSA-N

Canonical SMILES：COC1=C(C=CC(=C1)N2CCC(CC2)N)NC3=NC=C(C(=N3)C4=CNC5=CC=CC=C54)Cl

Isomeric SMILES：COC1=C(C=CC(=C1)N2CCC(CC2)N)NC3=NC=C(C(=N3)C4=CNC5=CC=CC=C54)Cl

PubChem CID：56599293

CAS Registry No.：1356962-20-3

溶解性：25°C DMSO

产品包装