产品名称

英文名称：BMS-663068

同义词

Fostemsavir、864953-29-7、BMS-663068、BMS-663068 free acid、BMS 663068、Fostemsavir [USAN]、Fostemsavir(BMS-663068)、97IQ273H4L、864953-29-7(free base)、Fostemsavir (USAN)、[3-[2-(4-benzoylpiperazin-1-yl)-2-oxoacetyl]-4-methoxy-7-(3-methyl-1,2,4-triazol-1-yl)pyrrol

产品性质

CAS编号：864953-29-7

分子式：C25H26N7O8P

分子量：583.49

PubChem编号：11319217

英文别名：Fostemsavir|864953-29-7|BMS-663068|BMS-663068 free acid|BMS 663068|Fostemsavir [USAN]|Fostemsavir(BMS-663068)|97IQ273H4L|864953-29-7(free base)|Fostemsavir (USAN)|[3-[2-(4-benzoylpiperazin-1-yl)-2-oxoacetyl]-4-methoxy-7-(3-methyl-1,2,4-triazol-1-yl)pyrrol

规格或纯度：98%

英文名称：BMS-663068

生化机理：BMS-663068 is an HIV-1 attachment inhibitor in development for the treatment of HIV-1 infection. BMS-663068 is a prodrμg for BMS-626529 which binds to the viral envelope glycoprotein gp120 and interferes with attachment of the virus to the cellular CD4 receptor. Administration of BMS-663068 for 8 days with or without ritonavir resulted in substantial declines in plasma HIV-1 RNA levels and was generally well tolerated. Longer-term clinical trials of BMS-663068 as part of combination antiretroviral therapy are warranted.

储存温度：-20°C储存

运输条件：超低温冰袋运输

ALogP：-0.1

IUPAC Name：[3-[2-(4-benzoylpiperazin-1-yl)-2-oxoacetyl]-4-methoxy-7-(3-methyl-1,2,4-triazol-1-yl)pyrrolo[2,3-c]pyridin-1-yl]methyl dihydrogen phosphate

INCHI：InChI=1S/C25H26N7O8P/c1-16-27-14-32(28-16)23-21-20(19(39-2)12-26-23)18(13-31(21)15-40-41(36,37)38)22(33)25(35)30-10-8-29(9-11-30)24(34)17-6-4-3-5-7-17/h3-7,12-14H,8-11,15H2,1-2H3,(H2,36,37,38)

InChi Key：SWMDAPWAQQTBOG-UHFFFAOYSA-N

Canonical SMILES：CC1=NN(C=N1)C2=NC=C(C3=C2N(C=C3C(=O)C(=O)N4CCN(CC4)C(=O)C5=CC=CC=C5)COP(=O)(O)O)OC

Isomeric SMILES：CC1=NN(C=N1)C2=NC=C(C3=C2N(C=C3C(=O)C(=O)N4CCN(CC4)C(=O)C5=CC=CC=C5)COP(=O)(O)O)OC

PubChem CID：11319217

CAS Registry No.：864953-29-7

ChEMBL Ligand：CHEMBL3301594

DrugBank Ligand：DB11796

DrugCentral Ligand：5401

溶解性：DMSO

产品包装