产品名称

英文名称：AZD2858

同义词

AZD2858、486424-20-8、AZD-2858、3-amino-6-(4-((4-methylpiperazin-1-yl)sulfonyl)phenyl)-N-(pyridin-3-yl)pyrazine-2-carboxamide、AZD 2858、3-Amino-6-{4-[(4-Methylpiperazin-1-Yl)sulfonyl]phenyl}-N-Pyridin-3-Ylpyrazine-2-Carboxamide、3-amino-6-[4-(4-methylpiperazin

产品性质

CAS编号：486424-20-8

分子式：C21H23N7O3S

分子量：453.52

PubChem编号：10138980

英文别名：AZD2858|486424-20-8|AZD-2858|3-amino-6-(4-((4-methylpiperazin-1-yl)sulfonyl)phenyl)-N-(pyridin-3-yl)pyrazine-2-carboxamide|AZD 2858|3-Amino-6-{4-[(4-Methylpiperazin-1-Yl)sulfonyl]phenyl}-N-Pyridin-3-Ylpyrazine-2-Carboxamide|3-amino-6-[4-(4-methylpiperazin

规格或纯度：≥99%

英文名称：AZD2858

生化机理：AZD2858 is a selective GSK-3 inhibitor with an IC50 of 68 nM, inhibits tau phosphorylation at the S396 site, activates Wnt signaling pathway. AZD2858 treatment (1 μM, 12 h) on primary isolated human osteoblast-like cells results in a 3-fold increase of β-catenin levels. AZD2858 causes β-catenin stabilisation in human and rat mesenchymal stem cells, stimulates hADSC commitment towards osteoblasts and osteogenic mineralisation in vitro.Selective GSK-3 inhibitor (IC 50 = 68 nM) of tau phosphorylation at the S396 site, activating Wnt signaling pathway. Greater than 70-fold selective against a panel of other kinases, receptors and enzymes.

储存温度：-20°C储存

运输条件：超低温冰袋运输

备注：如果有可能，您尽量在使用的当天配置溶液，并在当天使用完它。但是，如果您需要预先配制储备溶液，我们建议您将溶液等份保存在-20°C的密封小瓶中。通常，它们最多可以使用一个月。在使用前和打开样品瓶之前，我们建议您让您的产品在室温下平衡至少1小时。需要更多关于溶解度，用法和处理的建议吗？请访问我们的常见问题（FAQ）页面以获取更多详细信息。

产品介绍：AZD2858是GSK-3抑制剂，能激活Wnt信号通路。AZD2858 is a selective GSK-3 inhibitor with an IC50 of 68 nM, inhibits tau phosphorylation at the S396 site, activates Wnt signaling pathway.

IUPAC Name：3-amino-6-[4-(4-methylpiperazin-1-yl)sulfonylphenyl]-N-pyridin-3-ylpyrazine-2-carboxamide

INCHI：InChI=1S/C21H23N7O3S/c1-27-9-11-28(12-10-27)32(30,31)17-6-4-15(5-7-17)18-14-24-20(22)19(26-18)21(29)25-16-3-2-8-23-13-16/h2-8,13-14H,9-12H2,1H3,(H2,22,24)(H,25,29)

InChi Key：FHCSBLWRGCOVPT-UHFFFAOYSA-N

Canonical SMILES：CN1CCN(CC1)S(=O)(=O)C2=CC=C(C=C2)C3=CN=C(C(=N3)C(=O)NC4=CN=CC=C4)N

Isomeric SMILES：CN1CCN(CC1)S(=O)(=O)C2=CC=C(C=C2)C3=CN=C(C(=N3)C(=O)NC4=CN=CC=C4)N

PubChem CID：10138980

ChEMBL Ligand：CHEMBL2177161

CAS Registry No.：486424-20-8

RCSB PDB Ligand：GR9

Reactome Reaction：R-HSA-9687724

Reactome Drug：R-ALL-9687651

溶解性：25°C DMSO 7 mg/mL; Water <1 mg/mL; Ethanol <1mg/mL

象形图：

信号词：Danger

危险声明：H301 Toxic if swallowedH341 Suspected of causing genetic defectsH372 Causes damage to organs through prolonged or repeated exposure

预防措施声明：P321,P405,P501,P264,P260,P281,P270,P330,P203,P301+P316,P318,P319

产品包装