产品名称

英文名称：Auraptene

同义词

Auraptene、Aurapten、495-02-3、7-Geranyloxycoumarin、F79I1ZEL2E、7-[(2E)-3,7-dimethylocta-2,6-dienoxy]chromen-2-one、(E)-7-((3,7-Dimethylocta-2,6-dien-1-yl)oxy)-2H-chromen-2-one、2H-1-Benzopyran-2-one, 7-((3,7-dimethyl-2,6-octadienyl)oxy)-, (E)-、7-{[(2E)-3,7-dim、7-香叶基氧基香豆素、7-[[(2E)-3,7-二甲基-2,6-辛二烯-1-基]氧]-2H-苯并吡喃-2-酮

产品性质

CAS编号：495-02-3

分子式：C19H22O3

分子量：298.38

MDL号：MFCD00075948

PubChem编号：1550607

别名：7-香叶基氧基香豆素|7-[[(2E)-3,7-二甲基-2,6-辛二烯-1-基]氧]-2H-苯并吡喃-2-酮

英文别名：Auraptene|Aurapten|495-02-3|7-Geranyloxycoumarin|F79I1ZEL2E|7-[(2E)-3,7-dimethylocta-2,6-dienoxy]chromen-2-one|(E)-7-((3,7-Dimethylocta-2,6-dien-1-yl)oxy)-2H-chromen-2-one|2H-1-Benzopyran-2-one, 7-((3,7-dimethyl-2,6-octadienyl)oxy)-, (E)-|7-{[(2E)-3,7-dim

规格或纯度：≥98% (HPLC)

英文名称：Auraptene

生化机理：Auraptene is an estrogen receptor modulator that also acts as an ACAT inhibitor. It displays anti-tumor effects in several xenograft and chemically-induced murine tumor models. Auraptene induces apoptosis and is anti-proliferative in cancer cell lines. It has agonistic properties against PPARs, and interferes with lipid and cholesterol production by inhibiting ACAT (IC50 = 4 uM). Auraptene (7-geranyloxycoumarin) possesses anti-oxidant, anti-bacterial, anti-inflammatory and anti-tumor activities.

应用：Auranofin inhibits both leukocyte activation pathways at multiple sites and the release of inflammatory mediators from human macrophages, basophils, and pulmonary mast cells. Auranofin also inhibits 5-lipoxygenase in human neutrophils, IKB kinase (IKK) by modifying Cys-179 of the IKKβ subunit 5 and selenoenzyme thioredoxin reductase (TrxR) which is involved in the defense against oxidative stress. Auranofin is a disease-modifying antirheumatic drug (DMARD) and has been used to study the anti-proliferative effects against OVCAR-3 human ovarian carcinoma cells.

储存温度：-20°C储存

运输条件：超低温冰袋运输

产品介绍：Auraptene (7-geranyloxycoumarin) is a prenyloxycoumarin, that is abundantly present in nature. It is produced by several plant species, such as Rutaceae and Umbeliferae (Apiaceae) familiesAuranofin inhibits both leukocyte activation pathways at multiple sites and the release of inflammatory mediators from human macrophages, basophils, and pulmonary mast cells. Auranofin also inhibits 5-lipoxygenase in human neutrophils, IKB kinase (IKK) by modifying Cys-179 of the IKKβ subunit 5 and selenoenzyme thioredoxin reductase (TrxR) which is involved in the defense against oxidative stress. Auranofin is a disease-modifying antirheumatic drμg (DMARD) and has been used to study the anti-proliferative effects against OVCAR-3 human ovarian carcinoma cells.Auraptene (7-geranyloxycoumarin) is a prenyloxycoumarin, that is abundantly present in nature. It is produced by several plant species, such as Rutaceae and Umbeliferae (Apiaceae) families

IUPAC Name：7-[(2E)-3,7-dimethylocta-2,6-dienoxy]chromen-2-one

INCHI：InChI=1S/C19H22O3/c1-14(2)5-4-6-15(3)11-12-21-17-9-7-16-8-10-19(20)22-18(16)13-17/h5,7-11,13H,4,6,12H2,1-3H3/b15-11+

InChi Key：RSDDHGSKLOSQFK-RVDMUPIBSA-N

Canonical SMILES：CC(=CCCC(=CCOC1=CC2=C(C=C1)C=CC(=O)O2)C)C

Isomeric SMILES：CC(=CCC/C(=C/COC1=CC2=C(C=C1)C=CC(=O)O2)/C)C

WGK Germany：3

RTECS：MD6500000

PubChem CID：1550607

溶解性：DMSO >20 mg/mL

敏感性：对热敏感

熔点：66°C

象形图：

信号词：Danger

危险声明：H301 Toxic if swallowedH361 Suspected of damaging fertility or the unborn child

预防措施声明：P301+P310,P281

个人防护装备：dust mask type N95 (US), Eyeshields, Faceshields, Gloves

产品包装