产品名称

英文名称：Paclitaxel

同义词

33069-62-4、P88XT4IS4D、Paclitaxel、Taxol、Taxol A、Yewtaxan、Genaxol、Plaxicel、Abraxane、Ebetaxel、Genetaxyl、Capxol、Cyclopax、Genexol、Intaxel、Mitotax、Paxene、Onxol、TaxAlbin、OncoGel、Pacliex、Paxceed、EmPAC、Onxal、Zisu、Taxus stent、Taxus Liberte、ABI-007、Padexol、EndoTAG 1

产品性质

CAS编号：33069-62-4

分子式：C47H51NO14

分子量：853.91

Beilstein号：1420457

MDL号：MFCD00869953

PubChem编号：36314

英文别名：33069-62-4|P88XT4IS4D|Paclitaxel|Taxol|Taxol A|Yewtaxan|Genaxol|Plaxicel|Abraxane|Ebetaxel|Genetaxyl|Capxol|Cyclopax|Genexol|Intaxel|Mitotax|Paxene|Onxol|TaxAlbin|OncoGel|Pacliex|Paxceed|EmPAC|Onxal|Zisu|Taxus stent|Taxus Liberte|ABI-007|Padexol|EndoTAG 1

规格或纯度：99%

英文名称：Paclitaxel

生化机理：抗肿瘤剂；促进并稳定微管蛋白聚合，导致细胞周期停滞。在CCRF-HSB-2细胞中诱导caspase-10的自催化激活，从而引发细胞凋亡。

储存温度：2-8°C储存

运输条件：冰袋运输

产品介绍：Paclitaxel是一种微管聚合物稳定剂，作用于人内皮细胞，IC50为0.1 pM有效的抗肿瘤的药物;结合β-微管蛋白的N -端区域，促进了高度稳定的微管形成体，抵制解聚，防止正常细胞分裂和捕获在细胞周期的G2 / M期。Paclitaxel is a microtubule polymer stabilizer with IC50 of 0.1 pM in human endothelial cells. An antineoplastic and apoptosis inducing agent

ALogP：2.5

PubChem SID：488183273

PubChem SID url：https//pubchem.ncbi.nlm.nih.gov/substance/488183273

IUPAC Name：[(1S,2S,3R,4S,7R,9S,10S,12R,15S)-4,12-diacetyloxy-15-[(2R,3S)-3-benzamido-2-hydroxy-3-phenylpropanoyl]oxy-1,9-dihydroxy-10,14,17,17-tetramethyl-11-oxo-6-oxatetracyclo[11.3.1.03,10.04,7]heptadec-13-en-2-yl] benzoate

INCHI：InChI=1S/C47H51NO14/c1-25-31(60-43(56)36(52)35(28-16-10-7-11-17-28)48-41(54)29-18-12-8-13-19-29)23-47(57)40(61-42(55)30-20-14-9-15-21-30)38-45(6,32(51)22-33-46(38,24-58-33)62-27(3)50)39(53)37(59-26(2)49)34(25)44(47,4)5/h7-21,31-33,35-38,40,51-52,57H,22-24H2,1-6H3,(H,48,54)/t31-,32-,33+,35-,36+,37+,38-,40-,45+,46-,47+/m0/s1

InChi Key：RCINICONZNJXQF-MZXODVADSA-N

Canonical SMILES：CC1=C2C(C(=O)C3(C(CC4C(C3C(C(C2(C)C)(CC1OC(=O)C(C(C5=CC=CC=C5)NC(=O)C6=CC=CC=C6)O)O)OC(=O)C7=CC=CC=C7)(CO4)OC(=O)C)O)C)OC(=O)C

Isomeric SMILES：CC1=C2[C@H](C(=O)[C@@]3([C@H](C[C@@H]4[C@]([C@H]3[C@@H]([C@@](C2(C)C)(C[C@@H]1OC(=O)[C@@H]([C@H](C5=CC=CC=C5)NC(=O)C6=CC=CC=C6)O)O)OC(=O)C7=CC=CC=C7)(CO4)OC(=O)C)O)C)OC(=O)C

WGK Germany：3

RTECS：DA8340700

PubChem CID：36314

UN Number：2811

Packing Group：I

溶解性：溶于ethanol, 最高浓度 (mg/mL) 21.35, 最高浓度(mM) 25；溶于DMSO, 最高浓度 (mg/mL) 85.39, 最高浓度(mM) 100 温和加热

密度：1.39

比旋光度：-49 ° (C=1, MeOH)

熔点：213-216°C

象形图：

信号词：Danger

危险声明：H315 Causes skin irritationH335 May cause respiratory irritationH341 Suspected of causing genetic defectsH413 May cause long lasting harmful effects to aquatic lifeH318 Causes serious eye damageH317 May cause an allergic skin reactionH334 May cause allergy or asthma symptoms or breathing difficulties if inhaledH372 Causes damage to organs through prolonged or repeated exposureH360 May damage fertility or the unborn childH340 May cause genetic defectsH361 Suspected of damaging fertility or the unborn child

预防措施声明：P261,P273,P280,P302+P352,P321,P405,P501,P264,P260,P284,P281,P271,P270,P304+P340,P403+P233,P272,P333+P313,P362+P364,P203,P264+P265,P305+P354+P338,P318,P317,P332+P317,P319,P342+P316

Class：6.1

Merck Index：6982

个人防护装备：Eyeshields,Faceshields,full-face particle respirator type N100 (US),Gloves,respirator cartridge type N100 (US),type P1 (EN143) respirator filter,type P3 (EN 143) respirator cartridges

产品包装