产品名称

英文名称：Paclitaxel

同义词

33069-62-4、P88XT4IS4D、Paclitaxel、Taxol、Taxol A、Yewtaxan、Genaxol、Plaxicel、Abraxane、Ebetaxel、Genetaxyl、Capxol、Cyclopax、Genexol、Intaxel、Mitotax、Paxene、Onxol、TaxAlbin、OncoGel、Pacliex、Paxceed、EmPAC、Onxal、Zisu、Taxus stent、Taxus Liberte、ABI-007、Padexol、EndoTAG 1

产品性质

CAS编号：33069-62-4

分子式：C47H51NO14

分子量：853.91

Beilstein号：1420457

MDL号：MFCD00869953

PubChem编号：36314

英文别名：33069-62-4|P88XT4IS4D|Paclitaxel|Taxol|Taxol A|Yewtaxan|Genaxol|Plaxicel|Abraxane|Ebetaxel|Genetaxyl|Capxol|Cyclopax|Genexol|Intaxel|Mitotax|Paxene|Onxol|TaxAlbin|OncoGel|Pacliex|Paxceed|EmPAC|Onxal|Zisu|Taxus stent|Taxus Liberte|ABI-007|Padexol|EndoTAG 1

规格或纯度：分析标准品,≥99%

英文名称：Paclitaxel

生化机理：Taxol, an antineoplastic and antimicrotubule agent, posses mechanisms of cytotoxic action and has a broad antineoplastic spectrum compared to the vinca alkaloids. Studies have shown that Taxol is an inhibitor of neurite outgrowth and initiation by destroying normal control of microtuble assemly in growing neurites and removing tubulin from the cytoplasm. At lower concentrations Taxol displays the capacity to slightly enhance the mechanisms of microtubule assembly in neurons, and in turn changes the morphogenetic properties of growing neurites. The mechanism for microtuble formation occurs by binding of Taxol to the N-terminal region of β-tubulin. These new microtubules are highly stable and resist depolymerization therefore preventing normal cell division and arresting cell cycle at the G2/M phase. It has been reported that Taxol also causes apoptotic cell death, internucleosomal DNA fragmentation, and inhibition of protein isoprenylation. Taxol is a potential activator of PKA and Raf.

储存温度：2-8°C储存

运输条件：冰袋运输

备注：Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Note Some researchers have found solubility issues in PBS. The recommended procedure (from researcher feedback) for successful solubilisation is as follows Solubilise 10 mg of ab120143 in 1.25 mL ethanol absolute, mix well, add 1.25mL Cremophor, homogenise. Store at -20°C and after 24 h, defreeze quickly and solubilise in PBS, no crystallisation observed. Please note, Abcam has not yet tested this method. Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

产品介绍：Paclitaxel是一种微管聚合物稳定剂，作用于人内皮细胞，IC50为0.1 pM结合β-微管蛋白的N -端区域，促进了高度稳定的微管形成体，抵制解聚，防止正常细胞分裂和捕获在细胞周期的G2 / M期。Paclitaxel is a microtubule polymer stabilizer with IC50 of 0.1 pM in human endothelial cells. An antineoplastic and apoptosis inducing agent

ALogP：2.5

IUPAC Name：[(1S,2S,3R,4S,7R,9S,10S,12R,15S)-4,12-diacetyloxy-15-[(2R,3S)-3-benzamido-2-hydroxy-3-phenylpropanoyl]oxy-1,9-dihydroxy-10,14,17,17-tetramethyl-11-oxo-6-oxatetracyclo[11.3.1.03,10.04,7]heptadec-13-en-2-yl] benzoate

INCHI：InChI=1S/C47H51NO14/c1-25-31(60-43(56)36(52)35(28-16-10-7-11-17-28)48-41(54)29-18-12-8-13-19-29)23-47(57)40(61-42(55)30-20-14-9-15-21-30)38-45(6,32(51)22-33-46(38,24-58-33)62-27(3)50)39(53)37(59-26(2)49)34(25)44(47,4)5/h7-21,31-33,35-38,40,51-52,57H,22-24H2,1-6H3,(H,48,54)/t31-,32-,33+,35-,36+,37+,38-,40-,45+,46-,47+/m0/s1

InChi Key：RCINICONZNJXQF-MZXODVADSA-N

Canonical SMILES：CC1=C2C(C(=O)C3(C(CC4C(C3C(C(C2(C)C)(CC1OC(=O)C(C(C5=CC=CC=C5)NC(=O)C6=CC=CC=C6)O)O)OC(=O)C7=CC=CC=C7)(CO4)OC(=O)C)O)C)OC(=O)C

Isomeric SMILES：CC1=C2[C@H](C(=O)[C@@]3([C@H](C[C@@H]4[C@]([C@H]3[C@@H]([C@@](C2(C)C)(C[C@@H]1OC(=O)[C@@H]([C@H](C5=CC=CC=C5)NC(=O)C6=CC=CC=C6)O)O)OC(=O)C7=CC=CC=C7)(CO4)OC(=O)C)O)C)OC(=O)C

WGK Germany：3

RTECS：DA8340700

PubChem CID：36314

UN Number：2811

Packing Group：I

CAS Registry No.：33069-62-4

DrugBank Ligand：DB01229

BindingDB Ligand：50001839

ChEBI：CHEBI45863

Wikipedia：Paclitaxel

ChEMBL Ligand：CHEMBL428647

NURSA Ligand：10.1621/ZJSTGVJ65V

RCSB PDB Ligand：TA1

PEP：paclitaxel

DrugCentral Ligand：2044

密度：1.39

比旋光度：-49 ° (C=1, MeOH)

熔点：213-216°C

象形图：

信号词：Danger

危险声明：H315 Causes skin irritationH335 May cause respiratory irritationH341 Suspected of causing genetic defectsH413 May cause long lasting harmful effects to aquatic lifeH318 Causes serious eye damageH317 May cause an allergic skin reactionH334 May cause allergy or asthma symptoms or breathing difficulties if inhaledH372 Causes damage to organs through prolonged or repeated exposureH360 May damage fertility or the unborn childH340 May cause genetic defectsH361 Suspected of damaging fertility or the unborn child

预防措施声明：P261,P273,P280,P302+P352,P321,P405,P501,P264,P260,P284,P281,P271,P270,P304+P340,P403+P233,P272,P333+P313,P362+P364,P203,P264+P265,P305+P354+P338,P318,P317,P332+P317,P319,P342+P316

Class：6.1

Merck Index：6982

个人防护装备：Eyeshields,Faceshields,full-face particle respirator type N100 (US),Gloves,respirator cartridge type N100 (US),type P1 (EN143) respirator filter,type P3 (EN 143) respirator cartridges

产品包装