产品名称

英文名称：Topotecan hydrochloride

同义词

TOPOTECAN HYDROCHLORIDE、119413-54-6、Topotecan Hcl、Hycamtin、Nogitecan hydrochloride、Topotecan (Hydrochloride)、Topotecan monohydrochloride、Evotopin、Topotecan teva、Topotecan Hospira、SK&F S-104864-A、Hycamptamine hydrochloride、potactasol、Topotecan hydrochlorid、盐酸拓扑替坎,盐酸拓扑特康

产品性质

CAS编号：119413-54-6

分子式：C23H24ClN3O5

分子量：457.91

MDL号：MFCD00866235

PubChem编号：60699

别名：盐酸拓扑替坎,盐酸拓扑特康

英文别名：TOPOTECAN HYDROCHLORIDE|119413-54-6|Topotecan Hcl|Hycamtin|Nogitecan hydrochloride|Topotecan (Hydrochloride)|Topotecan monohydrochloride|Evotopin|Topotecan teva|Topotecan Hospira|SK&F S-104864-A|Hycamptamine hydrochloride|potactasol|Topotecan hydrochlorid

规格或纯度：98%

英文名称：Topotecan hydrochloride

生化机理：拓扑异构酶I抑制剂。喜树碱的水溶性衍生物。抗癌剂。

储存温度：-20°C储存

运输条件：超低温冰袋运输

备注：如果有可能，您尽量在使用的当天配置溶液，并在当天使用完它。但是，如果您需要预先配制储备溶液，我们建议您将溶液等份保存在-20°C的密封小瓶中。通常，它们最多可以使用一个月。在使用前和打开样品瓶之前，我们建议您让您的产品在室温下平衡至少1小时。需要更多关于溶解度，用法和处理的建议吗？请访问我们的常见问题（FAQ）页面以获取更多详细信息。

产品介绍：Topotecan HCl (NSC609699, Nogitecan, SKFS 104864A) is a topoisomerase I inhibitor for MCF-7 Luc cells and DU-145 Luc cells with IC50 of 13 nM and 2 nM in cell-free assays, respectively. Topotecan HCl induces autophagy and apoptosis.Topotecan HCl (NSC609699, Nogitecan, SKFS 104864A) is a topoisomerase I inhibitor for MCF-7 Luc cells and DU-145 Luc cells with IC50 of 13 nM and 2 nM in cell-free assays, respectively. Topotecan HCl induces autophagy and apoptosis.

PubChem SID：488183404

PubChem SID url：https//pubchem.ncbi.nlm.nih.gov/substance/488183404

IUPAC Name：(19S)-8-[(dimethylamino)methyl]-19-ethyl-7,19-dihydroxy-17-oxa-3,13-diazapentacyclo[11.8.0.02,11.04,9.015,20]henicosa-1(21),2,4(9),5,7,10,15(20)-heptaene-14,18-dione;hydrochloride

INCHI：InChI=1S/C23H23N3O5.ClH/c1-4-23(30)16-8-18-20-12(9-26(18)21(28)15(16)11-31-22(23)29)7-13-14(10-25(2)3)19(27)6-5-17(13)24-20;/h5-8,27,30H,4,9-11H2,1-3H3;1H/t23-;/m0./s1

InChi Key：DGHHQBMTXTWTJV-BQAIUKQQSA-N

Canonical SMILES：CCC1(C2=C(COC1=O)C(=O)N3CC4=CC5=C(C=CC(=C5CN(C)C)O)N=C4C3=C2)O.Cl

Isomeric SMILES：CC[C@@]1(C2=C(COC1=O)C(=O)N3CC4=CC5=C(C=CC(=C5CN(C)C)O)N=C4C3=C2)O.Cl

PubChem CID：60699

敏感性：对光敏感

熔点：213-225°C

象形图：

信号词：Danger

危险声明：H315 Causes skin irritationH319 Causes serious eye irritationH335 May cause respiratory irritationH301 Toxic if swallowedH351 Suspected of causing cancerH412 Harmful to aquatic life with long lasting effectsH302 Harmful if swallowedH300 Fatal if swallowedH360 May damage fertility or the unborn childH340 May cause genetic defectsH350 May cause cancerH370 Causes damage to organsH361 Suspected of damaging fertility or the unborn childH360D May damage the unborn child

预防措施声明：P261,P305+P351+P338,P273,P280,P302+P352,P321,P405,P501,P264,P260,P281,P271,P270,P304+P340,P403+P233,P362+P364,P330,P203,P264+P265,P301+P316,P301+P317,P318,P337+P317,P308+P316,P332+P317,P319

Merck Index：9548

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