产品名称

英文名称：Chloramphenicol

同义词

chloramphenicol、56-75-7、Chloromycetin、Chlornitromycin、Levomycetin、Chloroamphenicol、Globenicol、Halomycetin、Levomicetina、Oleomycetin、Alficetyn、Chloramex、Chlorocid、Chlorocol、Fenicol、Chloramficin、Chloramfilin、Enteromycetin、Amphicol、Aquamycetin、Chloroptic、Clor、左旋霉素,左霉素、D-苏式-(-)-N-[α-(羟基甲基)-β-羟基-对硝基苯乙基]-2,2-二氯乙酰胺、D-(-)-苏-1-对硝基苯基-2-二氯乙酰胺基-1,3-丙二醇、2,2-二氯-N-[2-羟基-1-(羟甲基)]-2-(4-硝基苯基)-乙基]乙酰胺

产品性质

CAS编号：56-75-7

分子式：C11H12Cl2N2O5

分子量：323.13

Beilstein号：2225532

EC号：200-287-4

MDL号：MFCD00078159

PubChem编号：5959

别名：左旋霉素,左霉素|D-苏式-(-)-N-[α-(羟基甲基)-β-羟基-对硝基苯乙基]-2,2-二氯乙酰胺|D-(-)-苏-1-对硝基苯基-2-二氯乙酰胺基-1,3-丙二醇|2,2-二氯-N-[2-羟基-1-(羟甲基)]-2-(4-硝基苯基)-乙基]乙酰胺

英文别名：chloramphenicol|56-75-7|Chloromycetin|Chlornitromycin|Levomycetin|Chloroamphenicol|Globenicol|Halomycetin|Levomicetina|Oleomycetin|Alficetyn|Chloramex|Chlorocid|Chlorocol|Fenicol|Chloramficin|Chloramfilin|Enteromycetin|Amphicol|Aquamycetin|Chloroptic|Clor

规格或纯度：98%

英文名称：Chloramphenicol

生化机理：Mode of Action Chloramphenicol inhibits bacterial protein synthesis by blocking the peptidyl transferase step by binding to the 50S ribosomal subunit and preventing attachment of aminoacyl tRNA to the ribosome. It also inhibits mitochondrial and chloroplast protein synthesis and ribosomal formation of (p)ppGpp, de-pressing rRNA transcription. Mode of Resistance Use of chloramphenicol acetyltransferase will acetylate the product and inactivate it. Antimicrobial Spectrum This is a broad spectrum antibiotic against gram-positive and gram-negative bacteria, and is used mainly for ophthalmic and veterinary purposes.

应用：在转肽酶(peptidyl transferase)步骤抑制在50S 核糖体亚单元上的翻译。

储存温度：-20°C储存

运输条件：超低温冰袋运输

产品介绍：溶于甲醇、乙醇、丁醇、丙酮和乙酸乙酯，微溶于醚，不溶于苯和石油醚。产品介绍Chloramphenicol 是一种 (bacterial) 感染的广谱抗生素，作为细菌蛋白质生物合成的有效抑制剂。Chloramphenicol 主要作用于细菌 70S 核糖体的 50S 亚基，通过抑制肽基转移酶活性来抑制肽键的形成。applicationChloramphenicol is a synthetic antibiotic, isolated from strains of Streptomyces venezuelae. It is often used for bacterial selection in molecular biology applications at 10-20 μg/mL and as a selection agent for transformed cells containing chloramphenicol reistance genes.

ALogP：1.1

PubChem SID：488179973

PubChem SID url：https//pubchem.ncbi.nlm.nih.gov/substance/488179973

IUPAC Name：2,2-dichloro-N-[(1R,2R)-1,3-dihydroxy-1-(4-nitrophenyl)propan-2-yl]acetamide

INCHI：InChI=1S/C11H12Cl2N2O5/c12-10(13)11(18)14-8(5-16)9(17)6-1-3-7(4-2-6)15(19)20/h1-4,8-10,16-17H,5H2,(H,14,18)/t8-,9-/m1/s1

InChi Key：WIIZWVCIJKGZOK-RKDXNWHRSA-N

Canonical SMILES：C1=CC(=CC=C1C(C(CO)NC(=O)C(Cl)Cl)O)[N+](=O)[O-]

Isomeric SMILES：C1=CC(=CC=C1[C@H]([C@@H](CO)NC(=O)C(Cl)Cl)O)[N+](=O)[O-]

WGK Germany：3

RTECS：AB6825000

PubChem CID：5959

溶解性：Soluble in alcohol, propylene, glycol, acetone and ethyl acetate. Slightly soluble in water.

密度：1.547

敏感性：对光线敏感

比旋光度：20 ° (C=5, EtOH)

闪点(℉)：57.2°F closed cup

闪点(℃)：14.0°C closed cup

熔点：149-153°C

象形图：

信号词：Danger

危险声明：H351 Suspected of causing cancerH318 Causes serious eye damageH317 May cause an allergic skin reactionH360 May damage fertility or the unborn childH350 May cause cancerH361 Suspected of damaging fertility or the unborn child

预防措施声明：P261,P280,P302+P352,P321,P405,P501,P272,P333+P313,P362+P364,P203,P264+P265,P305+P354+P338,P318,P317

Merck Index：2077

个人防护装备：Eyeshields,Faceshields,full-face particle respirator type N100 (US),Gloves,respirator cartridge type N100 (US),type P1 (EN143) respirator filter,type P3 (EN 143) respirator cartridges

产品包装