产品名称

英文名称：(R)-(-)-2-Amino-5-phosphonopentanoic acid

同义词

D-AP5、79055-68-8、5-Phosphono-D-norvaline、(R)-2-Amino-5-phosphonopentanoic acid、d-APV、D-Norvaline, 5-phosphono-、(2R)-2-amino-5-phosphonopentanoic acid、D-(-)-2-Amino-5-phosphonopentanoic Acid、D-2-Amino-5-phosphonovaleric acid、D(-)-2-Amino-5-phosphonopentano、(R)-(-)-2-氨基-5-膦酰戊酸、D -2-氨基-5-膦酰戊酸、D(-)-2-氨基-5-膦戊酸

产品性质

CAS编号：79055-68-8

分子式：C5H12NO5P

分子量：197.13

MDL号：MFCD00078839

PubChem编号：135342

别名：(R)-(-)-2-氨基-5-膦酰戊酸、D -2-氨基-5-膦酰戊酸、D(-)-2-氨基-5-膦戊酸

英文别名：D-AP5|79055-68-8|5-Phosphono-D-norvaline|(R)-2-Amino-5-phosphonopentanoic acid|d-APV|D-Norvaline, 5-phosphono-|(2R)-2-amino-5-phosphonopentanoic acid|D-(-)-2-Amino-5-phosphonopentanoic Acid|D-2-Amino-5-phosphonovaleric acid|D(-)-2-Amino-5-phosphonopentano

规格或纯度：98%

英文名称：(R)-(-)-2-Amino-5-phosphonopentanoic acid

生化机理：Anticonvulsant; potent and selective N-methyl-D-aspartate (NMDA) receptor antagonist; active enantiomer of 2-amino-5-phosphonopentanoic acid.Competitive NMDA receptor glutamate site antagonist. More active form of DL-AP5.

储存温度：-20°C储存

运输条件：超低温冰袋运输

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产品介绍：D-AP5 is a selective antagonist of the NMDA receptor. D(-)-2-Amino-5-phosphonovaleric acid is described to antagonize amino acid-induced synaptic excitations, blocking L-aspartate and dorsal root-evoked spinal neuron excitation, without affecting cholinergic excitation induced by exogenous acetylcholine administration. Evoked electrical activity of neurons is suppressed by D(-)-2-Amino-5-phosphonovaleric acid antagonism of motoneuronal depolarizations at the NMDAR. The (+)-stereoisomer of D(-)-2-Amino-5-phosphonovaleric acid demonstrates considerably diminished NMDAR activity as compared to this (-)-isomer.A selective antagonist of the NMDA receptor.D-AP5 is a selective antagonist of the NMDA receptor. D(-)-2-Amino-5-phosphonovaleric acid is described to antagonize amino acid-induced synaptic excitations, blocking L-aspartate and dorsal root-evoked spinal neuron excitation, without affecting cholinergic excitation induced by exogenous acetylcholine administration. Evoked electrical activity of neurons is suppressed by D(-)-2-Amino-5-phosphonovaleric acid antagonism of motoneuronal depolarizations at the NMDAR. The (+)-stereoisomer of D(-)-2-Amino-5-phosphonovaleric acid demonstrates considerably diminished NMDAR activity as compared to this (-)-isomer.A selective antagonist of the NMDA receptor.

IUPAC Name：(2R)-2-amino-5-phosphonopentanoic acid

INCHI：InChI=1S/C5H12NO5P/c6-4(5(7)8)2-1-3-12(9,10)11/h4H,1-3,6H2,(H,7,8)(H2,9,10,11)/t4-/m1/s1

InChi Key：VOROEQBFPPIACJ-SCSAIBSYSA-N

Canonical SMILES：C(CC(C(=O)O)N)CP(=O)(O)O

Isomeric SMILES：C(C[C@H](C(=O)O)N)CP(=O)(O)O

WGK Germany：3

PubChem CID：135342

溶解性：Soluble in water (9 mg/ml), and 1 M NH4OH (50 mg/ml).

敏感性：对光线敏感

象形图：

信号词：Warning

危险声明：H315 Causes skin irritationH319 Causes serious eye irritationH335 May cause respiratory irritation

预防措施声明：P261,P305+P351+P338,P280,P302+P352,P321,P405,P501,P264,P271,P304+P340,P403+P233,P362+P364,P264+P265,P337+P317,P332+P317,P319

个人防护装备：dust mask type N95 (US), Eyeshields, Gloves

产品包装