产品名称

英文名称：6-(5H)-Phenanthridinone

同义词

6(5H)-Phenanthridinone、1015-89-0、Phenanthridin-6(5H)-one、Phenanthridone、6-Phenanthridinol、6-(5H)-phenanthridinone、5H-phenanthridin-6-one、6-Phenanthridinone、6-Phenanthridone、Phenantridone、phenanthridin-6-ol、Phenanthridone (misnomer)、5,6-dihydrophenanthridi、6(5H)-5-氮杂菲酮、6(5H)-菲啶酮

产品性质

CAS编号：1015-89-0

分子式：C13H9NO

分子量：195.22

EC号：213-804-3

MDL号：MFCD00004988

PubChem编号：1853

别名：6(5H)-5-氮杂菲酮|6(5H)-菲啶酮

英文别名：6(5H)-Phenanthridinone|1015-89-0|Phenanthridin-6(5H)-one|Phenanthridone|6-Phenanthridinol|6-(5H)-phenanthridinone|5H-phenanthridin-6-one|6-Phenanthridinone|6-Phenanthridone|Phenantridone|phenanthridin-6-ol|Phenanthridone (misnomer)|5,6-dihydrophenanthridi

规格或纯度：≥98.0%(HPLC)

英文名称：6-(5H)-Phenanthridinone

运输条件：常规运输

产品介绍：6(5H)-Phenanthridinone is a small molecule poly(ADP-ribose) polymerase (PARP) inhibitor with immunosupperessive effects. 6(5H)-Phenanthridinone has been shown to inhibit concanavilin A-induced lymphocyte proliferation, producing the observed immunosuppressant activity of this compound. It has also been shown to potentiate the effect of ionizing radiation on developing cells, strongly increasing the radiation-induced inhibition of cell proliferation, which sμggests use of 6(5H)-Phenanthridinone as a probe into the role of PARP in cellular response to irradiation. Treatment of cells with 6(5H)-Phenanthridinone and various DNA-damaging agents showed a resistance to apoptosis versus treatment with DNA-damaging agents alone, indicating that PARP activity is involved in the apoptotic process.Reactant involved in Synthesis of 5,6-dihydrophenanthridine sulfonamides. Oxidative coupling with diphenylacetylene. Direct copper acetate-catalyzed N-cyclopropylation of cyclic amides. Reactant involved in the synthesis and/or pharmacological activity of biologically active molecules including Potassium channel KV1.3 and IK-1 inhibitors. HIV-1 integrase inhibitors.6(5H)-Phenanthridinone is a small molecule poly(ADP-ribose) polymerase (PARP) inhibitor with immunosupperessive effects. 6(5H)-Phenanthridinone has been shown to inhibit concanavilin A-induced lymphocyte proliferation, producing the observed immunosuppressant activity of this compound. It has also been shown to potentiate the effect of ionizing radiation on developing cells, strongly increasing the radiation-induced inhibition of cell proliferation, which suggests use of 6(5H)-Phenanthridinone as a probe into the role of PARP in cellular response to irradiation. Treatment of cells with 6(5H)-Phenanthridinone and various DNA-damaging agents showed a resistance to apoptosis versus treatment with DNA-damaging agents alone, indicating that PARP activity is involved in the apoptotic process.Reactant involved in Synthesis of 5,6-dihydrophenanthridine sulfonamides. Oxidative coupling with diphenylacetylene. Direct copper acetate-catalyzed N-cyclopropylation of cyclic amides. Reactant involved in the synthesis and/or pharmacological activity of biologically active molecules including Potassium channel KV1.3 and IK-1 inhibitors. HIV-1 integrase inhibitors.

IUPAC Name：5H-phenanthridin-6-one

INCHI：InChI=1S/C13H9NO/c15-13-11-7-2-1-5-9(11)10-6-3-4-8-12(10)14-13/h1-8H,(H,14,15)

InChi Key：RZFVLEJOHSLEFR-UHFFFAOYSA-N

Canonical SMILES：C1=CC=C2C(=C1)C3=CC=CC=C3NC2=O

Isomeric SMILES：C1=CC=C2C(=C1)C3=CC=CC=C3NC2=O

RTECS：SG0370000

PubChem CID：1853

Reaxy-Rn：140641

熔点：288-294℃

象形图：

信号词：Warning

危险声明：H315 Causes skin irritationH319 Causes serious eye irritationH335 May cause respiratory irritation

预防措施声明：P261,P305+P351+P338,P280,P302+P352,P321,P405,P501,P264,P271,P304+P340,P403+P233,P362+P364,P264+P265,P337+P317,P332+P317,P319

产品包装