产品名称

英文名称：N-Formyl-Met-Leu-Phe

同义词

N-Formyl-Met-Leu-Phe、59880-97-6、FMLP、Chemotactic peptide、fMLF、N-Formyl-methionyl-leucyl-phenylalanine、F-Met-leu-phe、fMetLeuPhe、fMet-Leu-Phe、N-Formyl-L-methionyl-L-leucyl-L-phenylalanine、formyl-Met-Leu-Phe、N-FORMYLMETHIONINE LEUCYL-PHENYLALANINE、(S)-2-((S)、N-甲酰-L-甲硫氨酰-L-亮氨酰-L-苯丙氨酸,趋化肽、fMLP、N-甲酰基-Met-Leu-Phe

产品性质

CAS编号：59880-97-6

分子式：C21H31N3O5S

分子量：437.55

Beilstein号：2315783

MDL号：MFCD00036780

PubChem编号：443295

别名：N-甲酰-L-甲硫氨酰-L-亮氨酰-L-苯丙氨酸,趋化肽|fMLP|N-甲酰基-Met-Leu-Phe

英文别名：N-Formyl-Met-Leu-Phe|59880-97-6|FMLP|Chemotactic peptide|fMLF|N-Formyl-methionyl-leucyl-phenylalanine|F-Met-leu-phe|fMetLeuPhe|fMet-Leu-Phe|N-Formyl-L-methionyl-L-leucyl-L-phenylalanine|formyl-Met-Leu-Phe|N-FORMYLMETHIONINE LEUCYL-PHENYLALANINE|(S)-2-((S)

规格或纯度：97%

英文名称：N-Formyl-Met-Leu-Phe

生化机理：N-Formyl-Met-Leu-Phe induced chemotaxis in phosphoinositide 3-kinase γ (PI3K)γ-/- neutrophils, and promotes adhesion, polymerization of F-actin, Fcγ receptor-mediated phagocytosis and intracellular Ca2+ release. It acts as an inflammatory agent and activates polymorphonuclear leukocytes (PMNs) without the formation of 5-hydroxyicosatetraenoic acid (5-HETE) and leukotriene B4 (LTB4). Its effects on neutrophils and the inhibition of adenylate cyclase are inhibited by pertussis toxin. Potent chemotactic peptide. Induces a metabolic burst in macrophages accompanied by an increase in respiratory rate, secretion of lysosomal enzymes, and production of superoxide anion. Potent inducer of leucocyte chemotaxis and macrophage activator. Receptors that bind formylpeptides are found on phagocytic neutrophils and have recently been identified on cells of the intestinal mucosa.Potent endogenous chemotactic peptide and agonist for the formyl peptide receptor 1 (FPR1) (K i = 38 nM). Chemoattractant for phagocytic leukocytes. Stimulates random and directed locomotion. Inducer of superoxide release. Active in vitro .

应用：N-Formyl-Met-Leu-Phe has been used for · creating gradients in Zigmond chamber chemotaxis assay performed on neutrophils · use in neutrophil chemotaix assayand · determination of the involvement of MAPK-activating protein kinase-2 (MAPKAPK-2) and/or p38, in the signaling pathway of human polymorphonuclear leukocytes (PMNs) stimulated by N-Formyl-Met-Leu-Phe.

储存温度：-20°C储存

运输条件：超低温冰袋运输

备注：如果有可能，您尽量在使用的当天配置溶液，并在当天使用完它。但是，如果您需要预先配制储备溶液，我们建议您将溶液等份保存在-20°C的密封小瓶中。通常，这些产品最多可以使用一周。在使用前和打开样品瓶之前，我们建议您让您的产品在室温下平衡至少1小时。需要更多关于溶解度，用法和处理的建议吗？请访问我们的常见问题（FAQ）页面以获取更多详细信息。

产品介绍：N-Formyl-Met-Leu-Phe has been used for· creating gradients in Zigmond chamber chemotaxis assay performed on neutrophils· use in neutrophil chemotaix assayand· determination of the involvement of MAPK-activating protein kinase-2 (MAPKAPK-2) and/or p38, in the signaling pathway of human polymorphonuclear leukocytes (PMNs) stimulated by N-Formyl-Met-Leu-Phe.N-Formyl-Met-Leu-Phe has been used for· creating gradients in Zigmond chamber chemotaxis assay performed on neutrophils· use in neutrophil chemotaix assayand· determination of the involvement of MAPK-activating protein kinase-2 (MAPKAPK-2) and/or p38, in the signaling pathway of human polymorphonuclear leukocytes (PMNs) stimulated by N-Formyl-Met-Leu-Phe.

IUPAC Name：(2S)-2-[[(2S)-2-[[(2S)-2-formamido-4-methylsulfanylbutanoyl]amino]-4-methylpentanoyl]amino]-3-phenylpropanoic acid

INCHI：InChI=1S/C21H31N3O5S/c1-14(2)11-17(23-19(26)16(22-13-25)9-10-30-3)20(27)24-18(21(28)29)12-15-7-5-4-6-8-15/h4-8,13-14,16-18H,9-12H2,1-3H3,(H,22,25)(H,23,26)(H,24,27)(H,28,29)/t16-,17-,18-/m0/s1

InChi Key：PRQROPMIIGLWRP-BZSNNMDCSA-N

Canonical SMILES：CC(C)CC(C(=O)NC(CC1=CC=CC=C1)C(=O)O)NC(=O)C(CCSC)NC=O

Isomeric SMILES：CC(C)C[C@@H](C(=O)N[C@@H](CC1=CC=CC=C1)C(=O)O)NC(=O)[C@H](CCSC)NC=O

WGK Germany：3

关联CAS：59880-97-6

PubChem CID：443295

MeSH Entry Terms：F Met Leu Phe;F-Met-Leu-Phe;fMet Leu Phe;fMet-Leu-Phe;Formylmet Leu Phe;Formylmet-Leu-Phe;Formylmethionyl Leucyl Phenylalanine;Formylmethionyl Peptide;Formylmethionyl-Leucyl-Phenylalanine;Formylmethionylleucylphenylalanine;Leucyl-Phenylalanine, N-Formylme

敏感性：对热敏感

比旋光度：-8° (C=1,AcOH)

熔点：213 °C

个人防护装备：Eyeshields,Gloves,type N95 (US),type P1 (EN143) respirator filter

产品包装