产品名称

英文名称：PJ34

同义词

PJ34、344458-19-1、pj-34、N~2~,N~2~-DIMETHYL-N~1~-(6-OXO-5,6-DIHYDROPHENANTHRIDIN-2-YL)GLYCINAMIDE、2-(dimethylamino)-N-(6-oxo-5H-phenanthridin-2-yl)acetamide、2-(dimethylamino)-N-(6-oxo-5,6-dihydrophenanthridin-2-yl)acetamide、Acetamide, N-(5,6-dihydro-6-oxo-2

产品性质

CAS编号：344458-19-1

分子式：C17H17N3O2

分子量：295.34

PubChem编号：4858

英文别名：PJ34|344458-19-1|pj-34|N~2~,N~2~-DIMETHYL-N~1~-(6-OXO-5,6-DIHYDROPHENANTHRIDIN-2-YL)GLYCINAMIDE|2-(dimethylamino)-N-(6-oxo-5H-phenanthridin-2-yl)acetamide|2-(dimethylamino)-N-(6-oxo-5,6-dihydrophenanthridin-2-yl)acetamide|Acetamide, N-(5,6-dihydro-6-oxo-2

规格或纯度：≥98%

英文名称：PJ34

生化机理：PJ34 inhibited peroxynitrite-induced cell necrosis with EC50 of 20 nM. PJ34 provides cardioprotection by decreasing myocardial infarct size and enhancing postischemic regional and global functional recovery .Treatment with PJ34 increased NIS promoter activity without affecting PARP-1 binding to the promoter sequence, in addition to an increase of histone modification activation marks (H3K9K14ac, H3K4me3) .

储存温度：-20°C储存

运输条件：超低温冰袋运输

产品介绍：产品介绍 PJ34 是一种有效的特异性 PARPl/2 抑制剂，IC50 分别为 110 nM 和 86 nM。PJ34 is a novel potent specific inhibitor of PARP-l/2 with EC50 of 20 nM.

IUPAC Name：2-(dimethylamino)-N-(6-oxo-5H-phenanthridin-2-yl)acetamide

INCHI：InChI=1S/C17H17N3O2/c1-20(2)10-16(21)18-11-7-8-15-14(9-11)12-5-3-4-6-13(12)17(22)19-15/h3-9H,10H2,1-2H3,(H,18,21)(H,19,22)

InChi Key：UYJZZVDLGDDTCL-UHFFFAOYSA-N

Canonical SMILES：CN(C)CC(=O)NC1=CC2=C(C=C1)NC(=O)C3=CC=CC=C32

Isomeric SMILES：CN(C)CC(=O)NC1=CC2=C(C=C1)NC(=O)C3=CC=CC=C32

关联CAS：356042-41-6,344458-19-1

PubChem CID：4858

MeSH Entry Terms：N-(oxo-5,6-dihydrophenanthridin-2-yl)-N,N-dimethylacetamide hydrochloride;PJ 34;PJ-34;PJ34

溶解性：DMSO 28 mg/mL Water <1 mg/mL Ethanol <1 mg/mL

产品包装