产品名称

英文名称：Alfacalcidol

同义词

alfacalcidol、1-Hydroxycholecalciferol、41294-56-8、Alphacalcidol、1alpha-Hydroxyvitamin D3、Alfarol、Bondiol、EinsAlpha、Etalpha、Oxydevit、1-Hydroxyvitamin D3、1alpha-Hydroxycholecalciferol、Alsiodol、alpha-Calcidol、One-Alpha、Alfacalcidolum、Un-Alpha、1alpha-Hydroxy-v

产品性质

CAS编号：41294-56-8

分子式：C27H44O2

分子量：400.64

EC号：255-297-1

MDL号：MFCD00868328

PubChem编号：5282181

英文别名：alfacalcidol|1-Hydroxycholecalciferol|41294-56-8|Alphacalcidol|1alpha-Hydroxyvitamin D3|Alfarol|Bondiol|EinsAlpha|Etalpha|Oxydevit|1-Hydroxyvitamin D3|1alpha-Hydroxycholecalciferol|Alsiodol|alpha-Calcidol|One-Alpha|Alfacalcidolum|Un-Alpha|1alpha-Hydroxy-v

规格或纯度：97%

英文名称：Alfacalcidol

生化机理：Synthetic vitamin D3 analog that is metabolized to 1,25-dihydroxycholecalcif?erol. Inhibits bone resorption and stimulates bone formation. Supresses parathyroid hormone secretion by bovine parathyroid cells. Cholecalciferol is an inactive form of vitamin D3 which undergoes various levels of hydroxylation to form active vitamin D3 analogs. 1α-Hydroxyvitamin D3 (alfacalcidol is a synthetic analog that is metabolized to 1,25-dihydroxycholecalcif?erol, the biologically active form of vitamin D3 in calcium absorption and deposition. 1α,25-Dihydroxyvitamin D3 has widespread effects on cellular differentiation and proliferation, and can modulate immune responsiveness, and central nervous system function. Recent studies sμggest that 1α,25-dihydroxyvitamin D3 acts as a chemopreventive agent against several malignancies including cancers of the prostate and colon and shows synergy with other anticancer compounds.Metabolite of cholecalciferol. Shows osteoprotective effects in vivo . Orally active.

储存温度：-20°C储存

运输条件：超低温冰袋运输

备注：如果有可能，您尽量在使用的当天配置溶液，并在当天使用完它。但是，如果您需要预先配制储备溶液，我们建议您将溶液等份保存在-20°C的密封小瓶中。通常，它们最多可以使用一个月。在使用前和打开样品瓶之前，我们建议您让您的产品在室温下平衡至少1小时。有毒，请参阅SDS以获取更多信息。需要更多关于溶解度，用法和处理的建议吗？请访问我们的常见问题（FAQ）页面以获取更多详细信息。

ALogP：6.8

IUPAC Name：(1R,3S,5Z)-5-[(2E)-2-[(1R,3aS,7aR)-7a-methyl-1-[(2R)-6-methylheptan-2-yl]-2,3,3a,5,6,7-hexahydro-1H-inden-4-ylidene]ethylidene]-4-methylidenecyclohexane-1,3-diol

INCHI：InChI=1S/C27H44O2/c1-18(2)8-6-9-19(3)24-13-14-25-21(10-7-15-27(24,25)5)11-12-22-16-23(28)17-26(29)20(22)4/h11-12,18-19,23-26,28-29H,4,6-10,13-17H2,1-3,5H3/b21-11+,22-12-/t19-,23-,24-,25+,26+,27-/m1/s1

InChi Key：OFHCOWSQAMBJIW-AVJTYSNKSA-N

Canonical SMILES：CC(C)CCCC(C)C1CCC2C1(CCCC2=CC=C3CC(CC(C3=C)O)O)C

Isomeric SMILES：C[C@H](CCCC(C)C)[C@H]1CC[C@@H]\2[C@@]1(CCC/C2=C\C=C/3\C[C@H](C[C@@H](C3=C)O)O)C

WGK Germany：3

RTECS：VS2851000

PubChem CID：5282181

敏感性：对空气敏感，对热敏感

比旋光度：36° (C=0.3,CHCl3)

熔点：136 °C

象形图：

信号词：Danger

危险声明：H300 Fatal if swallowedH310 Fatal in contact with skinH330 Fatal if inhaled

预防措施声明：P280,P302+P352,P321,P405,P501,P264,P260,P284,P271,P270,P304+P340,P403+P233,P330,P262,P320,P361+P364,P301+P316,P316

Merck Index：4819

个人防护装备：Eyeshields, Faceshields, full-face particle respirator type N100 (US), Gloves, respirator cartridge type N100 (US), type P1 (EN143) respirator filter, type P3 (EN 143) respirator cartridges

产品包装