产品名称

英文名称：K252b

同义词

99570-78-2、k-252b、9,12-Epoxy-1H-diindolo[1,2,3-fg3',2',1'-kl]pyrrolo[3,4-i][1,6]benzodiazocine-10-carboxylicacid, 2,3,9,10,11,12-hexahydro-10-hydroxy-9-methyl-1-oxo-, (9S,10R,12R)-、CHEMBL4750633、(15S,16R,18R)-16-Hydroxy-15-methyl-3-oxo-28-oxa-4,14,19-tri

产品性质

CAS编号：99570-78-2

分子式：C26H19N3O5

分子量：453.5

PubChem编号：9981344

英文别名：99570-78-2|k-252b|9,12-Epoxy-1H-diindolo[1,2,3-fg3',2',1'-kl]pyrrolo[3,4-i][1,6]benzodiazocine-10-carboxylicacid, 2,3,9,10,11,12-hexahydro-10-hydroxy-9-methyl-1-oxo-, (9S,10R,12R)-|CHEMBL4750633|(15S,16R,18R)-16-Hydroxy-15-methyl-3-oxo-28-oxa-4,14,19-tri

规格或纯度：≥97%(HPLC)

英文名称：K252b

储存温度：-20°C储存

运输条件：超低温冰袋运输

产品介绍：K252B an inhibitor of protein kinase A, C, G K-252b is a general, cell permeable protein kinase inhibitor which acts by binding to the ATP binding domain of the kinase. K-252b is a potent inhibitor of CaMKII (Ca2+/calmodulin kinase II), MYLK (myosin light chain kinase, Ki=0.147 μM), PKA (cAMP- dependent protein kinase, Ki=0.09 μM), PKC (protein kinase C, Ki=0.02 μM), and cGKI (cGMP-dependent protein kinase, Ki=0.1 μM).An antibiotic and a strong inhibitor of protein kinase C (PKC)K252B an inhibitor of protein kinase A, C, G K-252b is a general, cell permeable protein kinase inhibitor which acts by binding to the ATP binding domain of the kinase. K-252b is a potent inhibitor of CaMKII (Ca2+/calmodulin kinase II), MYLK (myosin light chain kinase, Ki=0.147 μM), PKA (cAMP- dependent protein kinase, Ki=0.09 μM), PKC (protein kinase C, Ki=0.02 μM), and cGKI (cGMP-dependent protein kinase, Ki=0.1 μM).An antibiotic and a strong inhibitor of protein kinase C (PKC)

IUPAC Name：(15S,16R,18R)-16-hydroxy-15-methyl-3-oxo-28-oxa-4,14,19-triazaoctacyclo[12.11.2.115,18.02,6.07,27.08,13.019,26.020,25]octacosa-1,6,8,10,12,20,22,24,26-nonaene-16-carboxylic acid

INCHI：InChI=1S/C26H19N3O5/c1-25-26(33,24(31)32)10-17(34-25)28-15-8-4-2-6-12(15)19-20-14(11-27-23(20)30)18-13-7-3-5-9-16(13)29(25)22(18)21(19)28/h2-9,17,33H,10-11H2,1H3,(H,27,30)(H,31,32)/t17-,25+,26+/m1/s1

InChi Key：AMSOPBXQXSAAAC-PLZPTFKGSA-N

Canonical SMILES：CC12C(CC(O1)N3C4=CC=CC=C4C5=C6C(=C7C8=CC=CC=C8N2C7=C53)CNC6=O)(C(=O)O)O

Isomeric SMILES：C[C@@]12[C@](C[C@@H](O1)N3C4=CC=CC=C4C5=C6C(=C7C8=CC=CC=C8N2C7=C53)CNC6=O)(C(=O)O)O

PubChem CID：9981344

溶解性：Soluble in DMSO (1 mg/ml), DMF (1 mg/ml), and methanol (2 mg/ml).

密度：1.78

敏感性：对光线和湿度敏感，易吸潮

沸点：769.82 °C at 760 mmHg

熔点：318.16°C

产品包装