产品名称

英文名称：Brinzolamide

同义词

AL 4862、AZARGA COMPONENT BRINZOLAMIDE、CCG-222516、GTPL6797、HCRKCZRJWPKOAR-JTQLQIEISA-N、(4R)-4-(ethylamino)-2-(3-methoxypropyl)-1,1-dioxo-2H,3H,4H-1$l^{6},7,2-thieno[3,2-e][1,2]thiazine-6-sulfonamide、(4R)-4-(ethylamino)-2-(3-methoxypropyl)-3,4-dihydro-2H-th、布林佐胺

产品性质

CAS编号：138890-62-7

分子式：C12H21N3O5S3

分子量：383.51

EC号：620-511-8

MDL号：MFCD08067749

PubChem编号：68844

别名：布林佐胺

英文别名：AL 4862|AZARGA COMPONENT BRINZOLAMIDE|CCG-222516|GTPL6797|HCRKCZRJWPKOAR-JTQLQIEISA-N|(4R)-4-(ethylamino)-2-(3-methoxypropyl)-1,1-dioxo-2H,3H,4H-1$l^{6},7,2-thieno[3,2-e][1,2]thiazine-6-sulfonamide|(4R)-4-(ethylamino)-2-(3-methoxypropyl)-3,4-dihydro-2H-th

规格或纯度：≥98%

英文名称：Brinzolamide

生化机理：Brinzolamide is a carbonic anhydrase II inhibitor used to lower intraocular pressure.Potent, selective, non-competitive and reversible carbonic anhydrase II inhibitor (IC 50 = 2 nM). Decreases aqueous humor secretion. Increases blood flow to the optic nerve. Lowers intraocular pressure in vivo.

应用：Brinzolamide has been used as a melanin binding compound or drug in melanin binding assays. It has also been used as a carbonic anhydrase inhibitor (CAI).

储存温度：-20°C储存

运输条件：超低温冰袋运输

备注：如果有可能，您尽量在使用的当天配置溶液，并在当天使用完它。但是，如果您需要预先配制储备溶液，我们建议您将溶液等份保存在-20°C的密封小瓶中。通常，它们最多可以使用一个月。在使用前和打开样品瓶之前，我们建议您让您的产品在室温下平衡至少1小时。需要更多关于溶解度，用法和处理的建议吗？请访问我们的常见问题（FAQ）页面以获取更多详细信息。

产品介绍：Brinzolamide是一种强有效的碳酸酐酶–II抑制剂，IC50为3.19 nM。Brinzolamide has been used as a melanin binding compound or drμg in melanin binding assays. It has also been used as a carbonic anhydrase inhibitor (CAI).Brinzolamide is a potent carbonic anhydrase II inhibitor with IC50 of 3.19 nM.Brinzolamide has been used as a melanin binding compound or drug in melanin binding assays. It has also been used as a carbonic anhydrase inhibitor (CAI).

IUPAC Name：(4R)-4-(ethylamino)-2-(3-methoxypropyl)-1,1-dioxo-3,4-dihydrothieno[3,2-e]thiazine-6-sulfonamide

INCHI：InChI=1S/C12H21N3O5S3/c1-3-14-10-8-15(5-4-6-20-2)23(18,19)12-9(10)7-11(21-12)22(13,16)17/h7,10,14H,3-6,8H2,1-2H3,(H2,13,16,17)/t10-/m0/s1

InChi Key：HCRKCZRJWPKOAR-JTQLQIEISA-N

Canonical SMILES：CCNC1CN(S(=O)(=O)C2=C1C=C(S2)S(=O)(=O)N)CCCOC

Isomeric SMILES：CCN[C@H]1CN(S(=O)(=O)C2=C1C=C(S2)S(=O)(=O)N)CCCOC

WGK Germany：3

RTECS：XJ9095055

关联CAS：138890-62-7

PubChem CID：68844

MeSH Entry Terms：(R)-4-(ethylamino)-3,4-dihydro-2-(3-methoxypropyl)-2H-thieno(3,2-E)-1,2-thiazine-6-sulfonamide 1,1-dioxide;Azopt;brinzolamide

溶解性：DMSO ≥10 mg/mL

敏感性：对热和湿度敏感

熔点：132 °C

象形图：

信号词：Warning

危险声明：H302 Harmful if swallowedH312 Harmful in contact with skinH332 Harmful if inhaledH302+H332 Harmful if swallowed or if inhaled

预防措施声明：P261,P280,P302+P352,P321,P501,P264,P271,P270,P304+P340,P362+P364,P330,P301+P317,P317

Merck Index：1376

产品包装