产品名称

英文名称：Desloratadine

同义词

Desloratadine、100643-71-8、Clarinex、Descarboethoxyloratadine、Desloratidine、Neoclarityn、Aerius、Azomyr、Denosin、Sch-34117、Opulis、Allex、Sch 34117、8-Chloro-11-piperidin-4-ylidene-6,11-dihydro-5H-benzo[5,6]cyclohepta[1,2-b]pyridine、Desloratadine Actavis、Dasselta、地氯雷他定

产品性质

CAS编号：100643-71-8

分子式：C19H19ClN2

分子量：310.83

MDL号：MFCD00871949

PubChem编号：124087

别名：地氯雷他定

英文别名：Desloratadine|100643-71-8|Clarinex|Descarboethoxyloratadine|Desloratidine|Neoclarityn|Aerius|Azomyr|Denosin|Sch-34117|Opulis|Allex|Sch 34117|8-Chloro-11-piperidin-4-ylidene-6,11-dihydro-5H-benzo[5,6]cyclohepta[1,2-b]pyridine|Desloratadine Actavis|Dasselta

规格或纯度：>98.0%(HPLC)(T)

英文名称：Desloratadine

生化机理：It is a selective and nonsedating histamine H1 receptor antagonist, an active metabolite of loratadine (Claritin), used to relieve hay fever and allergy symptoms with less drowsiness than other antihistamines; does not significantly inhibits cardiac K+ channels at clinically achievable blood levels. Free from antimuscarinic/anticholinergic effects.Highly potent, selective H 1 receptor antagonist (K i = 0.97 pM). Inhibits release of inflammatory mediators, including IL-4, IL-6, IL-8, IL-13, PGD(2), leukotriene C4 and tryptase. Anti-inflammatory and antihistaminergic. Orally active. Active in vivo an

储存温度：2-8°C储存,充氩

运输条件：冰袋运输

备注：如果有可能，您尽量在使用的当天配置溶液，并在当天使用完它。但是，如果您需要预先配制储备溶液，我们建议您将溶液等份保存在-20°C的密封小瓶中。通常，它们最多可以使用一个月。在使用前和打开样品瓶之前，我们建议您让您的产品在室温下平衡至少1小时。需要更多关于溶解度，用法和处理的建议吗？请访问我们的常见问题（FAQ）页面以获取更多详细信息。

产品介绍：Desloratadine is a potent and selective histamine H1-receptor agonist with a half life of 21-24 hours. Experiments sμggest that this compound also exerts antioxidant effects in vitro. Other studies show that H1-receptor binding by desloratadine is reversible and that, over time, desloratadine dissociates from membrane H1-recepters. Desloratadine has also demonstrated the ability to block ICAM-1 upregulation and NFκB activation in primary bronchial and transformed respiratory epithelial cells in vitro.Desloratadine是人H1受体拮抗剂。Desloratadine is a potent and selective histamine H1-receptor agonist with a half life of 21-24 hours. Experiments suggest that this compound also exerts antioxidant effects in vitro. Other studies show that H1-receptor binding by desloratadine is reversible and that, over time, desloratadine dissociates from membrane H1-recepters. Desloratadine has also demonstrated the ability to block ICAM-1 upregulation and NFκB activation in primary bronchial and transformed respiratory epithelial cells in vitro.It is a potent antagonist for human histamine H1 receptor used to treat allergies.

ALogP：4.5

IUPAC Name：13-chloro-2-piperidin-4-ylidene-4-azatricyclo[9.4.0.03,8]pentadeca-1(11),3(8),4,6,12,14-hexaene

INCHI：InChI=1S/C19H19ClN2/c20-16-5-6-17-15(12-16)4-3-14-2-1-9-22-19(14)18(17)13-7-10-21-11-8-13/h1-2,5-6,9,12,21H,3-4,7-8,10-11H2

InChi Key：JAUOIFJMECXRGI-UHFFFAOYSA-N

Canonical SMILES：C1CC2=C(C=CC(=C2)Cl)C(=C3CCNCC3)C4=C1C=CC=N4

Isomeric SMILES：C1CC2=C(C=CC(=C2)Cl)C(=C3CCNCC3)C4=C1C=CC=N4

PubChem CID：124087

DrugBank Ligand：DB00967

CAS Registry No.：100643-71-8

ChEMBL Ligand：CHEMBL1172

Wikipedia：Desloratadine

PEP：desloratadine

DrugCentral Ligand：814

GPCRdb Ligand：desloratadine

溶解性：Soluble in water (partly), ethanol, DMSO (>10 mg/ml), methanol, and chloroform.

敏感性：对热敏感; 对空气敏感

熔点：157 °C

象形图：

信号词：Danger

危险声明：H411 Toxic to aquatic life with long lasting effectsH302 Harmful if swallowedH318 Causes serious eye damageH317 May cause an allergic skin reactionH361 Suspected of damaging fertility or the unborn child

预防措施声明：P261,P273,P280,P302+P352,P321,P405,P501,P264,P270,P272,P333+P313,P362+P364,P391,P330,P203,P264+P265,P301+P317,P305+P354+P338,P318,P317

Merck Index：2922

产品包装