产品名称

英文名称：6,7-Dimethoxycoumarin

同义词

Scoparone、120-08-1、6,7-DIMETHOXYCOUMARIN、6,7-Dimethylesculetin、Escoparone、Scoparon、Aesculetin dimethyl ether、6,7-Dimethoxy-2H-chromen-2-one、Esculetin dimethyl ether、6,7-Dimethoxy-2-benzopyrone、6,7-dimethoxychromen-2-one、Scopoletin methyl ether、o-Methylsco、蒿属香豆素

产品性质

CAS编号：120-08-1

分子式：C11H10O4

分子量：206.19

EC号：204-369-0

MDL号：MFCD00006871

PubChem编号：8417

别名：蒿属香豆素

英文别名：Scoparone|120-08-1|6,7-DIMETHOXYCOUMARIN|6,7-Dimethylesculetin|Escoparone|Scoparon|Aesculetin dimethyl ether|6,7-Dimethoxy-2H-chromen-2-one|Esculetin dimethyl ether|6,7-Dimethoxy-2-benzopyrone|6,7-dimethoxychromen-2-one|Scopoletin methyl ether|o-Methylsco

规格或纯度：分析标准品,≥98%

英文名称：6,7-Dimethoxycoumarin

运输条件：常规运输

备注：10mg卖完停产，不再备货

产品介绍：Scoparone is a compound found in the herb, Yin Chin, that can up-regulate the expression and activate the CAR (constitutive androstane receptor) found in the liver. It has been shown to clear the accumulation of bilirubin by the activation of CAR in neonatal jaundice. Other studies show that scaparone inhibits lipopolysaccharide (LPS)-induced tissue factor (TF) expression in HUVECs and that it acts as an anti-inflammatory compound. TCPOBOP also transactivates CAR, however, scoparone can activate murine and human CAR. Scaparone can increase dopamine release by synapsin I phosphorylation throμgh activation of PKA and CaMKII? in PC12 cells. It can also activate neurite outgrowth and improve dopamine biosynthesis in PC12 cells.An agent that can up-regulate the expression and activate CARScoparone is a compound found in the herb, Yin Chin, that can up-regulate the expression and activate the CAR (constitutive androstane receptor) found in the liver. It has been shown to clear the accumulation of bilirubin by the activation of CAR in neonatal jaundice. Other studies show that scaparone inhibits lipopolysaccharide (LPS)-induced tissue factor (TF) expression in HUVECs and that it acts as an anti-inflammatory compound. TCPOBOP also transactivates CAR, however, scoparone can activate murine and human CAR. Scaparone can increase dopamine release by synapsin I phosphorylation through activation of PKA and CaMKII? in PC12 cells. It can also activate neurite outgrowth and improve dopamine biosynthesis in PC12 cells.An agent that can up-regulate the expression and activate CAR

IUPAC Name：6,7-dimethoxychromen-2-one

INCHI：InChI=1S/C11H10O4/c1-13-9-5-7-3-4-11(12)15-8(7)6-10(9)14-2/h3-6H,1-2H3

InChi Key：GUAFOGOEJLSQBT-UHFFFAOYSA-N

Canonical SMILES：COC1=C(C=C2C(=C1)C=CC(=O)O2)OC

Isomeric SMILES：COC1=C(C=C2C(=C1)C=CC(=O)O2)OC

WGK Germany：3

RTECS：GN6550000

PubChem CID：8417

UN Number：2811

溶解性：Soluble in DMSO (15 mg/ml), and water (partly miscible).

密度：1.248

熔点：143-145°C

象形图：

信号词：Danger

危险声明：H319 Causes serious eye irritationH301 Toxic if swallowed

预防措施声明：P305+P351+P338,P280,P321,P405,P501,P264,P270,P330,P264+P265,P301+P316,P337+P317

个人防护装备：dust mask type N95 (US),Eyeshields,Faceshields,Gloves

产品包装