产品名称

英文名称：NU6027

同义词

NU6027、220036-08-8、6-(cyclohexylmethoxy)-5-nitrosopyrimidine-2,4-diamine、NU 6027、NU-6027、2,6-diamino-4-cyclohexylmethoxy-5-nitrosopyrimidine、6-CYCLOHEXYLMETHYLOXY-5-NITROSO-PYRIMIDINE-2,4-DIAMINE、2,6-Diamino-4-(cyclohexylmethoxy)-5-nitrosopyrimidine; NU 6

产品性质

CAS编号：220036-08-8

分子式：C11H17N5O2

分子量：251.28

MDL号：MFCD05664735

PubChem编号：398148

英文别名：NU6027|220036-08-8|6-(cyclohexylmethoxy)-5-nitrosopyrimidine-2,4-diamine|NU 6027|NU-6027|2,6-diamino-4-cyclohexylmethoxy-5-nitrosopyrimidine|6-CYCLOHEXYLMETHYLOXY-5-NITROSO-PYRIMIDINE-2,4-DIAMINE|2,6-Diamino-4-(cyclohexylmethoxy)-5-nitrosopyrimidine; NU 6

规格或纯度：≥98%

英文名称：NU6027

生化机理：NU6027 is a potent inhibitor of ATR signalling.Selective cyclin-dependent kinase-2 (CDK2) inhibitor

储存温度：2-8°C储存

运输条件：冰袋运输

备注：卖完停产，不再备货

产品介绍：NU6027是一种有效的ATR/CDK抑制剂，抑制CDK1/2， ATR和DNA-PK时，Ki分别为2.5 μM/1.3 μM， 0.4 μM和 2.2 μM ，进入细胞时比6-氨基嘌呤类抑制剂更容易。A selective inhibitor of cyclin-dependent kinase-2 (CDK2).NU6027 is a potent ATR/CDK inhibitor, inhibits CDK1/2, ATR and DNA-PK with Ki of 2.5 μM/1.3 μM, 0.4 μM and 2.2 μM, enter cells more readily than the 6-aminopurine-based inhibitors.A selective inhibitor of cyclin-dependent kinase-2 (CDK2).

IUPAC Name：6-(cyclohexylmethoxy)-5-nitrosopyrimidine-2,4-diamine

INCHI：InChI=1S/C11H17N5O2/c12-9-8(16-17)10(15-11(13)14-9)18-6-7-4-2-1-3-5-7/h7H,1-6H2,(H4,12,13,14,15)

InChi Key：DGWXOLHKVGDQLN-UHFFFAOYSA-N

Canonical SMILES：C1CCC(CC1)COC2=NC(=NC(=C2N=O)N)N

Isomeric SMILES：C1CCC(CC1)COC2=NC(=NC(=C2N=O)N)N

WGK Germany：3

PubChem CID：398148

溶解性：DMSO 50 mg/mL Water <1 mg/mL Ethanol 3 mg/mL

熔点：252.5-253.7°C

个人防护装备：Eyeshields， Gloves， type N95 (US)， type P1 (EN143) respirator filter

产品包装