产品名称

英文名称：Epirubicin hydrochloride

同义词

Epirubicin hydrochloride、56390-09-1、Epirubicin HCl、Pharmorubicin、Ellence、Farmorubicin、Farmorubicina、Epirubitec、4'-Epidoxorubicin hydrochloride、Epidoxorubicin hydrochloride、CCRIS 4477、IMI-28、4'-epi-Adriamycin hydrochloride、Epirubicin Ebewe、epirubicin (hydr、盐酸表阿霉素、盐酸表阿霉素、(8S,10S)-10-[(3'-氨基-2',3',6'-三脱氧-alpha-L-阿拉伯吡喃糖基)-O-]-6,8,11-三羟基-8-羟乙酰基-1-甲氧基-7,8,9,10-四氢并四苯-5,12-二酮盐酸盐

产品性质

CAS编号：56390-09-1

分子式：C27H29NO11 · HCl

分子量：579.98

EC号：260-145-2

MDL号：MFCD00941448

PubChem编号：65348

别名：盐酸表阿霉素|盐酸表阿霉素|(8S,10S)-10-[(3'-氨基-2',3',6'-三脱氧-alpha-L-阿拉伯吡喃糖基)-O-]-6,8,11-三羟基-8-羟乙酰基-1-甲氧基-7,8,9,10-四氢并四苯-5,12-二酮盐酸盐

英文别名：Epirubicin hydrochloride|56390-09-1|Epirubicin HCl|Pharmorubicin|Ellence|Farmorubicin|Farmorubicina|Epirubitec|4'-Epidoxorubicin hydrochloride|Epidoxorubicin hydrochloride|CCRIS 4477|IMI-28|4'-epi-Adriamycin hydrochloride|Epirubicin Ebewe|epirubicin (hydr

规格或纯度：≥98% (HPLC)

英文名称：Epirubicin hydrochloride

生化机理：可渗透细胞的蒽环类抗肿瘤抗生素。抗肿瘤药。表柔比星的立体异构体表现出降低心脏毒性。其抗癌行动是由靶位点拓扑异构酶II介导的。表柔比星具抗有丝分裂和细胞毒性。它抑制核酸和蛋白质的合成。表柔比星通过与DNA形成复合物和并嵌入碱基对之间，通过使DNA拓扑异构酶Ⅱ复合稳定而抑制拓扑异构酶II活性。它抑制DNA螺旋酶的活性。拓扑异构酶II抑制剂（IC 50 = 12μM）。阿霉素的立体异构体（Asc 629）。显示体内抗肿瘤和抗血管生成活性。细胞可渗透的。

应用：表柔比星是一种细胞渗透性的蒽环类抗肿瘤抗生素。它是多柔比星表现出降低心脏毒性的立体异构体（4'-表异构体）。它常用来抑制拓扑异构酶II和DNA解旋酶的活性。表柔比星是用来研究转移性乳腺癌和心脏毒性。

储存温度：避光,-20°C储存

运输条件：超低温冰袋运输

备注：如果有可能，您尽量在使用的当天配置溶液，并在当天使用完它。但是，如果您需要预先配制储备溶液，我们建议您将溶液等份保存在-20°C的密封小瓶中。通常，它们最多可以使用一个月。在使用前和打开样品瓶之前，我们建议您让您的产品在室温下平衡至少1小时。需要更多关于溶解度，用法和处理的建议吗？请访问我们的常见问题（FAQ）页面以获取更多详细信息。

产品介绍：表柔比星是一种细胞渗透性的蒽环类抗肿瘤抗生素。它是多柔比星表现出降低心脏毒性的立体异构体（4'-表异构体）。它常用来抑制拓扑异构酶II和DNA解旋酶的活性。表柔比星是用来研究转移性乳腺癌和心脏毒性。This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the Issuing Pharmacopoeia. For further information and support please go to the website of the issuing Pharmacopoeiain solvent -80°C, 6 months; -20°C, 1 month (protect from light)This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the Issuing Pharmacopoeia. For further information and support please go to the website of the issuing PharmacopoeiaEpirubicin is a cell-permeable anthracycline antitumor antibiotic. It is a stereoisomer(4′-epi-isomer) of doxorubicin that exhibits reduced cardiotoxicity. It is used to inhibit topoisomerase II and DNA helicase activity. Epirubicin is used to study metastatic breast cancerand cardiac toxicity.in solvent -80°C, 6 months; -20°C, 1 month (protect from light)

IUPAC Name：(7S,9S)-7-[(2R,4S,5R,6S)-4-amino-5-hydroxy-6-methyloxan-2-yl]oxy-6,9,11-trihydroxy-9-(2-hydroxyacetyl)-4-methoxy-8,10-dihydro-7H-tetracene-5,12-dione;hydrochloride

INCHI：InChI=1S/C27H29NO11.ClH/c1-10-22(31)13(28)6-17(38-10)39-15-8-27(36,16(30)9-29)7-12-19(15)26(35)21-20(24(12)33)23(32)11-4-3-5-14(37-2)18(11)25(21)34;/h3-5,10,13,15,17,22,29,31,33,35-36H,6-9,28H2,1-2H3;1H/t10-,13-,15-,17-,22-,27-;/m0./s1

InChi Key：MWWSFMDVAYGXBV-FGBSZODSSA-N

Canonical SMILES：CC1C(C(CC(O1)OC2CC(CC3=C2C(=C4C(=C3O)C(=O)C5=C(C4=O)C(=CC=C5)OC)O)(C(=O)CO)O)N)O.Cl

Isomeric SMILES：C[C@H]1[C@@H]([C@H](C[C@@H](O1)O[C@H]2C[C@@](CC3=C2C(=C4C(=C3O)C(=O)C5=C(C4=O)C(=CC=C5)OC)O)(C(=O)CO)O)N)O.Cl

WGK Germany：3

RTECS：QI9295750

PubChem CID：65348

溶解性：Soluble in water (116 mg/mL) at 25 °C, DMSO (116 mg/mL) at 25 °C, ethanol (3 mg/mL) at 25 °C, acetone, and methanol.

敏感性：对光敏感；对热敏感；对湿度敏感

比旋光度：310° (C=0.05,MeOH)

熔点：185℃

象形图：

信号词：Danger

危险声明：H302 Harmful if swallowedH360 May damage fertility or the unborn childH340 May cause genetic defectsH350 May cause cancer

预防措施声明：P280,P405,P501,P264,P281,P270,P330,P203,P301+P317,P318

Merck Index：3623

个人防护装备：dust mask type N95 (US), Eyeshields, Gloves

产品包装