产品名称

英文名称：DAPT

同义词

dapt、208255-80-5、DAPT (GSI-IX)、GSI-IX、gamma-Secretase Inhibitor IX、tert-butyl (2S)-2-[[(2S)-2-[[2-(3,5-difluorophenyl)acetyl]amino]propanoyl]amino]-2-phenylacetate、CHEBI86193、C23H26F2N2O4、DAPT (GMP)、(S)-tert-butyl 2-((S)-2-(2-(3,5-difluorophenyl)acetamid、N-[N-(3,5-二氟苯乙酰)-L-丙氨酰]-S-苯甘氨酸叔丁酯、(3,5-二氟苯乙酰基)-Ala-Phg-OtBu、(3,5-二氟苯乙酰基)-L-丙氨酰基-L-2-苯基甘氨酸叔丁酯

产品性质

CAS编号：208255-80-5

分子式：C23H26F2N2O4

分子量：432.46

MDL号：MFCD04974585

PubChem编号：5311272

别名：N-[N-(3,5-二氟苯乙酰)-L-丙氨酰]-S-苯甘氨酸叔丁酯|(3,5-二氟苯乙酰基)-Ala-Phg-OtBu|(3,5-二氟苯乙酰基)-L-丙氨酰基-L-2-苯基甘氨酸叔丁酯

英文别名：dapt|208255-80-5|DAPT (GSI-IX)|GSI-IX|gamma-Secretase Inhibitor IX|tert-butyl (2S)-2-[[(2S)-2-[[2-(3,5-difluorophenyl)acetyl]amino]propanoyl]amino]-2-phenylacetate|CHEBI86193|C23H26F2N2O4|DAPT (GMP)|(S)-tert-butyl 2-((S)-2-(2-(3,5-difluorophenyl)acetamid

规格或纯度：≥98%

英文名称：DAPT

生化机理：DAPT is a potent and specific inhibitor of γ-secretase. It has been shown to cause a reduction in Aβ40 and Aβ42 levels in human primary neuronal cultures (IC50 values are 115 and 200 nM for total Aβ40 and Aβ42 respectively). There is evidence that DAPT does not effect APPα and APPβ levels. It mimics notch signaling deficiencies at morphological, molecular and biochemical levels and has been shown to block notch signaling in hybrid human-mouse foetal thymus organ culture (FTOC).γ-Secretase inhibitor. Inhibits Notch signalling in vitro . Inhibits total Aβ and Aβ42 production in human primary cultures (IC 50 values are 115 and 200 nM, respectively) with no effect on APPα and APPβ levels. Blood-brain barrier permeable.

储存温度：2-8°C储存,充氩

运输条件：冰袋运输

备注：5mg卖完停产，不再备货；如果有可能，您尽量在使用的当天配置溶液，并在当天使用完它。但是，如果您需要预先配制储备溶液，我们建议您将溶液等份保存在-20°C的密封小瓶中。通常，它们最多可以使用一个月。在使用前和打开样品瓶之前，我们建议您让您的产品在室温下平衡至少1小时。需要更多关于溶解度，用法和处理的建议吗？请访问我们的常见问题（FAQ）页面以获取更多详细信息。

产品介绍：DAPT (GSI-IX)是一种新型γ-分泌酶抑制剂，抑制HEK 293细胞中全部Aβ产量， IC50为20 nM。A potent and specific inhibitor of γ-secretase.DAPT (GSI-IX) is a novel γ-secretase inhibitor, which inhibits Aβ production with IC50 of 20 nM in HEK 293 cells.A potent and specific inhibitor of γ-secretase.

IUPAC Name：tert-butyl (2S)-2-[[(2S)-2-[[2-(3,5-difluorophenyl)acetyl]amino]propanoyl]amino]-2-phenylacetate

INCHI：InChI=1S/C23H26F2N2O4/c1-14(26-19(28)12-15-10-17(24)13-18(25)11-15)21(29)27-20(16-8-6-5-7-9-16)22(30)31-23(2,3)4/h5-11,13-14,20H,12H2,1-4H3,(H,26,28)(H,27,29)/t14-,20-/m0/s1

InChi Key：DWJXYEABWRJFSP-XOBRGWDASA-N

Canonical SMILES：CC(C(=O)NC(C1=CC=CC=C1)C(=O)OC(C)(C)C)NC(=O)CC2=CC(=CC(=C2)F)F

Isomeric SMILES：C[C@@H](C(=O)N[C@@H](C1=CC=CC=C1)C(=O)OC(C)(C)C)NC(=O)CC2=CC(=CC(=C2)F)F

WGK Germany：3

关联CAS：208255-80-5

PubChem CID：5311272

MeSH Entry Terms：DAPT butylester;DAPT peptide;GSI-IX cpd;N-(2FPhAc)Ala-phenyl-Gly t-butyl ester;N-(N-(3,5-difluorophenacetyl)alanyl)-S-phenylglycine t-butyl ester;N-(N-(3,5-difluorophenacetyl)alanyl)phenylglycine t-butyl ester;N-(N-(3,5-difluorophenacetyl)alanyl)phenylgly

溶解性：Soluble in DMSO (15 mg/mL), ethanol (~1 mg/mL), dichloromethane, DMF (~25 mg/mL), and 19 solution of DMFPBS(pH 7.2) (~0.1 mg/mL).

敏感性：对热敏感

个人防护装备：Eyeshields， Gloves， type N95 (US)， type P1 (EN143) respirator filter

产品包装