产品名称

英文名称：TRAM-34

同义词

TRAM-34、289905-88-0、1-((2-chlorophenyl)diphenylmethyl)-1H-pyrazole、1-[(2-Chlorophenyl)diphenylmethyl]-1H-pyrazole、Tram 34、TRAM34、Triarylmethane-34、C22H17ClN2、1-[(2-chlorophenyl)-diphenylmethyl]pyrazole、CHEMBL498270、CHEBI34990、1H-Pyrazole, 1-[(2-chlorophe、1-[(2-氯苯基)二苯甲基]-1H-吡唑

产品性质

CAS编号：289905-88-0

分子式：C22H17ClN2

分子量：344.84

MDL号：MFCD09842562

PubChem编号：656734

别名：1-[(2-氯苯基)二苯甲基]-1H-吡唑

英文别名：TRAM-34|289905-88-0|1-((2-chlorophenyl)diphenylmethyl)-1H-pyrazole|1-[(2-Chlorophenyl)diphenylmethyl]-1H-pyrazole|Tram 34|TRAM34|Triarylmethane-34|C22H17ClN2|1-[(2-chlorophenyl)-diphenylmethyl]pyrazole|CHEMBL498270|CHEBI34990|1H-Pyrazole, 1-[(2-chlorophe

规格或纯度：≥98%

英文名称：TRAM-34

生化机理：高效的选择性K Ca 3.1通道阻滞剂（IC 50 = 18 nM）。动脉粥样硬化和免疫抑制剂。在体外和体内具有活性。

储存温度：-20°C储存

运输条件：超低温冰袋运输

备注：如果有可能，您尽量在使用的当天配置溶液，并在当天使用完它。但是，如果您需要预先配制储备溶液，我们建议您将溶液等份保存在-20°C的密封小瓶中。通常，它们最多可以使用一个月。在使用前和打开样品瓶之前，我们建议您让您的产品在室温下平衡至少1小时。需要更多关于溶解度，用法和处理的建议吗？请访问我们的常见问题（FAQ）页面以获取更多详细信息。

产品介绍：TRAM-34 has been shown to be an inhibitor of cloned and native IK1 channels in human T lymphocytes. These K+ channels have been implicated in over-proliferation of cells. Inhibition of IK1 channels has been demonstrated to modulate cell proliferation depending on the concentration of TRAM-34. Mechanistic studies have shown that TRAM-34 may cause a halt in cell growth at the G0/G1 phase.TRAM-34 is a selective and potent inhibitor of the intermediate-conductance Ca2+-activated K+ channel (IKCa1, KCa3.1) with Kd of 20 nM, 200- to 1500-fold selective over other ion channels, and does not block cytochrome P450.TRAM-34 has been shown to be an inhibitor of cloned and native IK1 channels in human T lymphocytes. These K+ channels have been implicated in over-proliferation of cells. Inhibition of IK1 channels has been demonstrated to modulate cell proliferation depending on the concentration of TRAM-34. Mechanistic studies have shown that TRAM-34 may cause a halt in cell growth at the G0/G1 phase.TRAM-34是一种有效的，选择性的中电导Ca2+-activated K+ channel (IKCa1， KCa3.1)（钙激活的K+通道）抑制剂，Kd为20 nM，比作用于其他离子通道选择性高200到1500倍，且不抑制细胞色素P450。

IUPAC Name：1-[(2-chlorophenyl)-diphenylmethyl]pyrazole

INCHI：InChI=1S/C22H17ClN2/c23-21-15-8-7-14-20(21)22(25-17-9-16-24-25,18-10-3-1-4-11-18)19-12-5-2-6-13-19/h1-17H

InChi Key：KBFUQFVFYYBHBT-UHFFFAOYSA-N

Canonical SMILES：C1=CC=C(C=C1)C(C2=CC=CC=C2)(C3=CC=CC=C3Cl)N4C=CC=N4

Isomeric SMILES：C1=CC=C(C=C1)C(C2=CC=CC=C2)(C3=CC=CC=C3Cl)N4C=CC=N4

WGK Germany：3

PubChem CID：656734

ChEMBL Ligand：CHEMBL498270

BindingDB Ligand：50279107

CAS Registry No.：289905-88-0

溶解性：Soluble in DMSO (10 mg/ml at 40°C), ethanol (6 mg/ml at 40°C), and DMF (>25 mg/ml), dichloromethane, ethyl acetate, and methanol. Insoluble in water.

象形图：

信号词：Warning

危险声明：H413 May cause long lasting harmful effects to aquatic lifeH302 Harmful if swallowed

预防措施声明：P273,P501,P264,P270,P330,P301+P317

个人防护装备：dust mask type N95 (US), Eyeshields, Gloves

产品包装