产品名称

英文名称：Vorinostat (SAHA, MK0683)

同义词

Vorinostat、149647-78-9、SAHA、suberoylanilide hydroxamic acid、Zolinza、N-hydroxy-N'-phenyloctanediamide、N1-hydroxy-N8-phenyloctanediamide、Suberanilohydroxamic acid、MK-0683、MK0683、Octanediamide, N-hydroxy-N'-phenyl-、Vorinostat (SAHA, MK0683)、N'-hydroxy-N-phen、SAHA、异羟肟酸、N-羟基-N'-苯基辛二酰胺、伏立诺他、MK0683、辛二酰苯胺异羟肟酸

产品性质

CAS编号：149647-78-9

分子式：C14H20N2O3

分子量：264.32

MDL号：MFCD00945317

PubChem编号：5311

别名：SAHA|异羟肟酸|N-羟基-N'-苯基辛二酰胺|伏立诺他|MK0683|辛二酰苯胺异羟肟酸

英文别名：Vorinostat|149647-78-9|SAHA|suberoylanilide hydroxamic acid|Zolinza|N-hydroxy-N'-phenyloctanediamide|N1-hydroxy-N8-phenyloctanediamide|Suberanilohydroxamic acid|MK-0683|MK0683|Octanediamide, N-hydroxy-N'-phenyl-|Vorinostat (SAHA, MK0683)|N'-hydroxy-N-phen

规格或纯度：≥99.0%

英文名称：Vorinostat (SAHA, MK0683)

生化机理：SAHA或Vorinostat可促进导致细胞凋亡、分化和生长停滞的基因的转录。其已在淋巴瘤中获得有益结果，但在实体瘤中没有。 立诺他或辛二酰苯胺异羟肟酸（SAHA）是一种有效的、可逆的泛组蛋白去乙酰化酶（HDAC）抑制剂。其可抑制I类和II类HDAC，从而改变基因转录并诱导多种转化细胞中的细胞周期停滞和/或凋亡。高效的非选择性HDAC抑制剂（HDAC1和HDAC3的IC 50值分别为10和20 nM）。诱导凋亡并显示出对癌细胞系的抗增殖作用（IC 50 = 3-8μM）。体内抗肿瘤作用。

储存温度：-20°C储存

运输条件：超低温冰袋运输

备注：如果有可能，您尽量在使用的当天配置溶液，并在当天使用完它。但是，如果您需要预先配制储备溶液，我们建议您将溶液等份保存在-20°C的密封小瓶中。通常，它们最多可以使用一个月。在使用前和打开样品瓶之前，我们建议您让您的产品在室温下平衡至少1小时。需要更多关于溶解度，用法和处理的建议吗？请访问我们的常见问题（FAQ）页面以获取更多详细信息。

产品介绍：Suberoylanilide Hydroxamic Acid (SAHA) is a potent histone deacetylase (HDAC) inhibitor that has been shown to inhibit proliferation and cause cell cycle arrest at G1. Experiments suggest that SAHA also causes morphological changes, such as enlargement and flattening of the cytoplasm, resulting in growth inhibition. Treatment of cells with SAHA also decreases the expression of anti-apoptosis proteins Bcl-xL and survivin.A potent HDAC inhibitor; also causes cell cycle arrest at G1SAHA可用于研究基因调控、转录调控和细胞信号转导。Suberoylanilide Hydroxamic Acid (SAHA) is a potent histone deacetylase (HDAC) inhibitor that has been shown to inhibit proliferation and cause cell cycle arrest at G1. Experiments suggest that SAHA also causes morphological changes, such as enlargement and flattening of the cytoplasm, resulting in growth inhibition. Treatment of cells with SAHA also decreases the expression of anti-apoptosis proteins Bcl-xL and survivin.A potent HDAC inhibitor; also causes cell cycle arrest at G1SAHA may be used to study gene regulation, transcription regulation and cell signaling.

ALogP：1.9

PubChem SID：488179890

PubChem SID url：https//pubchem.ncbi.nlm.nih.gov/substance/488179890

IUPAC Name：N'-hydroxy-N-phenyloctanediamide

INCHI：InChI=1S/C14H20N2O3/c17-13(15-12-8-4-3-5-9-12)10-6-1-2-7-11-14(18)16-19/h3-5,8-9,19H,1-2,6-7,10-11H2,(H,15,17)(H,16,18)

InChi Key：WAEXFXRVDQXREF-UHFFFAOYSA-N

Canonical SMILES：C1=CC=C(C=C1)NC(=O)CCCCCCC(=O)NO

Isomeric SMILES：C1=CC=C(C=C1)NC(=O)CCCCCCC(=O)NO

WGK Germany：3

PubChem CID：5311

DrugBank Ligand：DB02546

CAS Registry No.：149647-78-9

ChEMBL Ligand：CHEMBL98

Wikipedia：Vorinostat

RCSB PDB Ligand：SHH

PEP：vorinostat

Reactome Reaction：R-HSA-9679787

Reactome Drug：R-ALL-9679755

DrugCentral Ligand：4124

溶解性：Soluble in ethanol (3 mg/ml at 25 °C), DMSO (53 mg/ml at 25 °C), DMF (~20 mg/ml), water (1.17 mg/ml at 25 °C), and methanol.

敏感性：对热敏感

熔点：155 °C

象形图：

信号词：Danger

危险声明：H341 Suspected of causing genetic defectsH302 Harmful if swallowedH400 Very toxic to aquatic lifeH410 Very toxic to aquatic life with long lasting effectsH372 Causes damage to organs through prolonged or repeated exposureH360 May damage fertility or the unborn child

预防措施声明：P273,P280,P405,P501,P264,P260,P281,P270,P391,P330,P203,P301+P317,P318,P319

Merck Index：10034

产品包装