产品名称

英文名称：Atazanavir Sulfate

同义词

Atazanavir sulfate、229975-97-7、Reyataz、Atazanavir sulphate、Atazanavir (sulfate)、BMS-232632-05、Atazor、Atazanavir so4、Atazanavir sulfate [USAN]、UNII-4MT4VIE29P、4MT4VIE29P、BMS-232632 sulfate、NSC-742546、CHEBI31243、DTXSID401017206、229975-97-7 (sulfate)、NSC 74、阿扎那韦硫酸盐、(3S,8S,9S,12S)-9-苄基-3,12,二叔丁基-8-羟基-4,11-二氧代-6-(对-2-吡啶基苄基)-2,5,6,10,13-五氮杂十四烷二酸二甲酯硫酸盐 [(5S,8S,9S,14S)-8-苄基-5-(叔丁基)-9-羟基-15,15-二甲基-3,6,13-三氧代-11-[4-(吡啶-2-基)苄基]-2-氧杂-4,7,11,12-四氮杂十六烷-14-基]氨基甲酸甲酯硫酸盐

产品性质

CAS编号：229975-97-7

分子式：C38H52N6O7.H2SO4

分子量：802.93

MDL号：MFCD08067748

PubChem编号：158550

别名：阿扎那韦硫酸盐|(3S,8S,9S,12S)-9-苄基-3,12,二叔丁基-8-羟基-4,11-二氧代-6-(对-2-吡啶基苄基)-2,5,6,10,13-五氮杂十四烷二酸二甲酯硫酸盐 [(5S,8S,9S,14S)-8-苄基-5-(叔丁基)-9-羟基-15,15-二甲基-3,6,13-三氧代-11-[4-(吡啶-2-基)苄基]-2-氧杂-4,7,11,12-四氮杂十六烷-14-基]氨基甲酸甲酯硫酸盐

英文别名：Atazanavir sulfate|229975-97-7|Reyataz|Atazanavir sulphate|Atazanavir (sulfate)|BMS-232632-05|Atazor|Atazanavir so4|Atazanavir sulfate [USAN]|UNII-4MT4VIE29P|4MT4VIE29P|BMS-232632 sulfate|NSC-742546|CHEBI31243|DTXSID401017206|229975-97-7 (sulfate)|NSC 74

规格或纯度：≥98%

英文名称：Atazanavir Sulfate

生化机理：Atazanavir sulfate is a sulfate salt form of atazanavir that is an highly potent HIV-1 protease inhibitor. Has shown to be generally more potent than the five currently approved HIV-1 Prt inhibitors. Atazanavir (BMS-232632) inhibited the proteolytic cleavage of the viral gag precursor p55 polyprotein in a dose-dependent manner, with a EC50 of approximately 47 nM. Also highly selective for HIV-1 Prt and exhibits cytotoxicity only at concentrations 6,500- to 23,000-fold higher than that required for anti-HIV activity. Atazanavir (BMS-232632) may be an effective HIV-1 inhibitor that may be utilized in a variety of different drμg combinations.

应用：A sulfate salt form of atazanavir that is an highly potent HIV-1 protease inhibitor.

储存温度：2-8°C储存,充氩

运输条件：冰袋运输

备注：5mg、50mg、250mg、10mg卖完停产，不再备货

产品介绍：Atazanavir Sulfate是一种HIV protease（HIV蛋白酶）抑制剂，抑制HIV Atazanavir，Ki值为2.66 nM。A sulfate salt form of atazanavir that is an highly potent HIV-1 protease inhibitor.Atazanavir is a HIV protease inhibitor with Ki of 2.66 nM.A sulfate salt form of atazanavir that is an highly potent HIV-1 protease inhibitor.

IUPAC Name：methyl N-[(2S)-1-[2-[(2S,3S)-2-hydroxy-3-[[(2S)-2-(methoxycarbonylamino)-3,3-dimethylbutanoyl]amino]-4-phenylbutyl]-2-[(4-pyridin-2-ylphenyl)methyl]hydrazinyl]-3,3-dimethyl-1-oxobutan-2-yl]carbamate;sulfuric acid

INCHI：InChI=1S/C38H52N6O7.H2O4S/c1-37(2,3)31(41-35(48)50-7)33(46)40-29(22-25-14-10-9-11-15-25)30(45)24-44(43-34(47)32(38(4,5)6)42-36(49)51-8)23-26-17-19-27(20-18-26)28-16-12-13-21-39-28;1-5(2,3)4/h9-21,29-32,45H,22-24H2,1-8H3,(H,40,46)(H,41,48)(H,42,49)(H,43,47);(H2,1,2,3,4)/t29-,30-,31+,32+;/m0./s1

InChi Key：DQSGVVGOPRWTKI-QVFAWCHISA-N

Canonical SMILES：CC(C)(C)C(C(=O)NC(CC1=CC=CC=C1)C(CN(CC2=CC=C(C=C2)C3=CC=CC=N3)NC(=O)C(C(C)(C)C)NC(=O)OC)O)NC(=O)OC.OS(=O)(=O)O

Isomeric SMILES：CC(C)(C)[C@@H](C(=O)N[C@@H](CC1=CC=CC=C1)[C@H](CN(CC2=CC=C(C=C2)C3=CC=CC=N3)NC(=O)[C@H](C(C)(C)C)NC(=O)OC)O)NC(=O)OC.OS(=O)(=O)O

PubChem CID：158550

溶解性：Soluble in water (4-5 mg/ml), and methanol.

敏感性：对空气敏感，对热敏感

象形图：

信号词：Danger

危险声明：H315 Causes skin irritationH319 Causes serious eye irritationH335 May cause respiratory irritationH411 Toxic to aquatic life with long lasting effectsH302 Harmful if swallowedH318 Causes serious eye damageH372 Causes damage to organs through prolonged or repeated exposure

预防措施声明：P261,P305+P351+P338,P273,P280,P302+P352,P321,P405,P501,P264,P260,P271,P270,P304+P340,P403+P233,P362+P364,P391,P330,P264+P265,P301+P317,P305+P354+P338,P317,P337+P317,P332+P317,P319

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