产品名称

英文名称：PD123319

同义词

PD123319、130663-39-7、PD 123319、PD-123319、CHEBI61014、(6S)-1-[4-(dimethylamino)-3-methylbenzyl]-5-(diphenylacetyl)-4,5,6,7-tetrahydro-1H-imidazo[4,5-c]pyridine-6-carboxylic acid、1H-Imidazo[4,5-c]pyridine-6-carboxylic acid, 1-[[4-(dimethylamino)-3-methylphe

产品性质

CAS编号：130663-39-7

分子式：C31H32N4O3

分子量：508.61

PubChem编号：5311345

英文别名：PD123319|130663-39-7|PD 123319|PD-123319|CHEBI61014|(6S)-1-[4-(dimethylamino)-3-methylbenzyl]-5-(diphenylacetyl)-4,5,6,7-tetrahydro-1H-imidazo[4,5-c]pyridine-6-carboxylic acid|1H-Imidazo[4,5-c]pyridine-6-carboxylic acid, 1-[[4-(dimethylamino)-3-methylphe

规格或纯度：98%

英文名称：PD123319

生化机理：PD 123319 is shown to discriminate between two subclasses of AII receptors in many different tissues. 125I-AII specifically label two classes of binding sites for AII in a membrane preparation of bovine adrenal glomerulosa cells. The first class (DuP-753 sensitive) represents approximately 85% of the total binding sites for AII and possesses a high affinity (IC50 of 92.9 nM) for DuP-753. PD-123319 does not have any effect on 125I-AII binding to this site. The second class of binding sites is more sensitive to PD-123319, with an IC50 of 6.9 nM, and has a much lower affinity for DuP-753 (IC50 around 10 microM)。

储存温度：-20°C储存

运输条件：超低温冰袋运输

产品介绍：产品介绍PD 123319是血管紧张素II受体拮抗剂，IC50为34 nM。product descriptionPD 123319 (ditrifluoroacetate) is a potent, selective AT2 angiotensin II receptor antagonist with IC50 of 34 nM.

IUPAC Name：(6S)-1-[[4-(dimethylamino)-3-methylphenyl]methyl]-5-(2,2-diphenylacetyl)-6,7-dihydro-4H-imidazo[4,5-c]pyridine-6-carboxylic acid

INCHI：InChI=1S/C31H32N4O3/c1-21-16-22(14-15-26(21)33(2)3)18-34-20-32-25-19-35(28(31(37)38)17-27(25)34)30(36)29(23-10-6-4-7-11-23)24-12-8-5-9-13-24/h4-16,20,28-29H,17-19H2,1-3H3,(H,37,38)/t28-/m0/s1

InChi Key：YSTVFDAKLDMYCR-NDEPHWFRSA-N

Canonical SMILES：CC1=C(C=CC(=C1)CN2C=NC3=C2CC(N(C3)C(=O)C(C4=CC=CC=C4)C5=CC=CC=C5)C(=O)O)N(C)C

Isomeric SMILES：CC1=C(C=CC(=C1)CN2C=NC3=C2C[C@H](N(C3)C(=O)C(C4=CC=CC=C4)C5=CC=CC=C5)C(=O)O)N(C)C

PubChem CID：5311345

ChEBI：CHEBI61014

ChEMBL Ligand：CHEMBL321820

BindingDB Ligand：50010338

CAS Registry No.：130663-39-7

GPCRdb Ligand：PD123319

溶解性：DMSO 100 mg/mL Water 100 mg/mL Ethanol 100 mg/mL

产品包装