产品名称

英文名称：Idarubicin HCl

同义词

idarubicin hydrochloride、Idarubicin Hcl、57852-57-0、Idamycin、Zavedos、Idarubicin (hydrochloride)、Idamycin PFS、IMI 30、UNII-5VV3MDU5IE、5VV3MDU5IE、Idarubicin hydrochloride PFS、IMI-30、DTXSID0047797、4-Demethoxydaunorubicin hydrochloride、EINECS 260-990-7、Idarubic、盐酸依达比星

产品性质

CAS编号：57852-57-0

分子式：C26H27NO9·HCl

分子量：533.95

PubChem编号：636362

别名：盐酸依达比星

英文别名：idarubicin hydrochloride|Idarubicin Hcl|57852-57-0|Idamycin|Zavedos|Idarubicin (hydrochloride)|Idamycin PFS|IMI 30|UNII-5VV3MDU5IE|5VV3MDU5IE|Idarubicin hydrochloride PFS|IMI-30|DTXSID0047797|4-Demethoxydaunorubicin hydrochloride|EINECS 260-990-7|Idarubic

规格或纯度：≥98%

英文名称：Idarubicin HCl

生化机理：Idarubicin Hydrochloride is the hydrochloride salt preparation of Idarubicin (IDA), an anthracycline and an analog of daunorubicin. IDA is rapidly metabolized to its 13-dihydroderivative (Idarubicinol) which is more stable than the parent form. This compound has been reported to trigger apoptotic cell death via enhancement of Fas and caspase-3/caspase-7 expression. In experiments, where cells were exposed to IDA, reactive oxygen species (ROS) were produced which induced DNA strand breaks and prevented DNA polymerase reaction. Idarubicin Hydrochloride is an inhibitor of Topo II α. Idarubicin Hydrochloride is also a substrate of CYP2D6 and CYP2C9.

储存温度：-20°C储存

运输条件：超低温冰袋运输

产品介绍：Idarubicin HCl是Idarubicin的盐酸盐形式，是蒽环类抗生素，抑制DNA拓扑异构酶II (topo II)，作用于MCF-7细胞，IC50为3.3 ng/mL。An apoptosis inducer.Idarubicin HCl is a hydrochloride salt form of Idarubicin which is an anthracycline antibiotic and a DNA topoisomerase II (topo II) inhibitor for MCF-7 cells with IC50 of 3.3 ng/mL.An apoptosis inducer.

PubChem SID：488190836

PubChem SID url：https//pubchem.ncbi.nlm.nih.gov/substance/488190836

IUPAC Name：(7S,9S)-9-acetyl-7-[(2R,4S,5S,6S)-4-amino-5-hydroxy-6-methyloxan-2-yl]oxy-6,9,11-trihydroxy-8,10-dihydro-7H-tetracene-5,12-dione;hydrochloride

INCHI：InChI=1S/C26H27NO9.ClH/c1-10-21(29)15(27)7-17(35-10)36-16-9-26(34,11(2)28)8-14-18(16)25(33)20-19(24(14)32)22(30)12-5-3-4-6-13(12)23(20)31;/h3-6,10,15-17,21,29,32-34H,7-9,27H2,1-2H3;1H/t10-,15-,16-,17-,21+,26-;/m0./s1

InChi Key：JVHPTYWUBOQMBP-RVFAQHLVSA-N

Canonical SMILES：CC1C(C(CC(O1)OC2CC(CC3=C2C(=C4C(=C3O)C(=O)C5=CC=CC=C5C4=O)O)(C(=O)C)O)N)O.Cl

Isomeric SMILES：C[C@H]1[C@H]([C@H](C[C@@H](O1)O[C@H]2C[C@@](CC3=C2C(=C4C(=C3O)C(=O)C5=CC=CC=C5C4=O)O)(C(=O)C)O)N)O.Cl

WGK Germany：3

RTECS：HB7877000

PubChem CID：636362

溶解性：DMSO 100 mg/mL (187.28 mM);Water 7 mg/mL heating (13.1 mM);Ethanol <1 mg/mL (<1 mM)

象形图：

信号词：Danger

危险声明：H341 Suspected of causing genetic defectsH351 Suspected of causing cancerH300 Fatal if swallowedH360 May damage fertility or the unborn child

预防措施声明：P280,P321,P405,P501,P264,P281,P270,P330,P203,P301+P316,P318

个人防护装备：Eyeshields， Faceshields， full-face particle respirator type N100 (US)， Gloves， respirator cartridge type N100 (US)， type P1 (EN143) respirator filter， type P3 (EN 143) respirator cartridges

产品包装