产品名称

英文名称：ZM 306416

同义词

690206-97-4、ZM 306416、ZM306416、N-(4-chloro-2-fluorophenyl)-6,7-dimethoxyquinazolin-4-amine、ZM-306416、ZM-306416(CB 676475)、CB 676475、CB-676475、CHEMBL150315、N-(4-Chloro-2-fluorophenyl)-6,7-dimethoxy-4-quinazolinamine、4-[(4'-chloro-2'-fluoro)phenylamino]-6,7

产品性质

CAS编号：690206-97-4

分子式：C16H13ClFN3O2

分子量：333.74

PubChem编号：5329006

英文别名：690206-97-4|ZM 306416|ZM306416|N-(4-chloro-2-fluorophenyl)-6,7-dimethoxyquinazolin-4-amine|ZM-306416|ZM-306416(CB 676475)|CB 676475|CB-676475|CHEMBL150315|N-(4-Chloro-2-fluorophenyl)-6,7-dimethoxy-4-quinazolinamine|4-[(4'-chloro-2'-fluoro)phenylamino]-6,7

规格或纯度：≥98%

英文名称：ZM 306416

生化机理：Description IC50 Value 0.67uM(for VEGFR); 0.33±0.08uM(for Src); 1.3±0.2 μM(for Abl) ZM-306416, a vascular endothelial growth factor receptor (VEGFR) antagonist, was identified as a potent inhibitor of EGFR function [2]. in vitro 306416 was found to be very potent toward the EGFR kinase with an IC50 value lower than 10 nM, reaching our assay detection limit and confirming our result using the EGFRB assay. ZM-306416 exhibited inhibitory activity across all three kinases of the panel, yielding IC50 values of 0.33±0.08 μM for SRC, 0.33±0.04 μM for VEGFR1, and 1.3±0.2 μM for ABL kinases [1]. in vivo N/A Clinical trial N/A

储存温度：-20°C储存

运输条件：超低温冰袋运输

备注：卖完停产，不再备货

产品介绍：ZM-306416(CB 676475)是VEGFR选择性抑制剂（IC50为670nM），对于Flk-1(KDR)和Flt的IC50分别为100nM和2μM。ZM-306416(CB 676475) is a VEGFR inhibitor that inhibits Flk-1 (KDR) (IC50=100 nM) and Flt (IC50 =2 μM); displays 4-fold selectivity over FGFR-1; inhibitor of c-Abl, Flt-1 and Src

IUPAC Name：N-(4-chloro-2-fluorophenyl)-6,7-dimethoxyquinazolin-4-amine

INCHI：InChI=1S/C16H13ClFN3O2/c1-22-14-6-10-13(7-15(14)23-2)19-8-20-16(10)21-12-4-3-9(17)5-11(12)18/h3-8H,1-2H3,(H,19,20,21)

InChi Key：YHUIUSRCUKUUQA-UHFFFAOYSA-N

Canonical SMILES：COC1=C(C=C2C(=C1)C(=NC=N2)NC3=C(C=C(C=C3)Cl)F)OC

Isomeric SMILES：COC1=C(C=C2C(=C1)C(=NC=N2)NC3=C(C=C(C=C3)Cl)F)OC

PubChem CID：5329006

CAS Registry No.：690206-97-4

ChEMBL Ligand：CHEMBL150315

溶解性：DMSO3 mg/mL; ethanol1 mg/mL, DMSO3 mg/mL; ethanol1 mg/mL

产品包装