产品名称

英文名称：Cediranib

同义词

AZD2171、NSC755606、NSC-755606、MFCD09954115、Recentin、Cediranib - AZD2171、D08881、N-acetyl-N-formyl-5-methoxykynuramine、XXJWYDDUDKYVKI-UHFFFAOYSA-N、A24280、AZD 2171、HY-10205、ZD-2171、SCHEMBL157630、4-(4-Fluoro-2-methyl-1H-indol-5-yloxy)-6-methoxy-7-(3-pyrrolidin、西地尼布

产品性质

CAS编号：288383-20-0

分子式：C25H27FN4O3

分子量：450.52

PubChem编号：9933475

别名：西地尼布

英文别名：AZD2171|NSC755606|NSC-755606|MFCD09954115|Recentin|Cediranib - AZD2171|D08881|N-acetyl-N-formyl-5-methoxykynuramine|XXJWYDDUDKYVKI-UHFFFAOYSA-N|A24280|AZD 2171|HY-10205|ZD-2171|SCHEMBL157630|4-(4-Fluoro-2-methyl-1H-indol-5-yloxy)-6-methoxy-7-(3-pyrrolidin

规格或纯度：≥98%

英文名称：Cediranib

生化机理：Cediranib is VEGFR2 inhibitor. Cediranib inhibited VEGF-stimulated proliferation and KDR phosphorylation with IC50s of 0.4 and 0.5 nM, respectively.

储存温度：-20°C储存

运输条件：超低温冰袋运输

产品介绍：Cediranib (AZD2171)是一种高效的VEGFR(KDR)抑制剂，IC50为<1 nM，同时也抑制Flt1/4，IC50为5 nM/≤3 nM，此外对c-Kit和PDGFRβ也具有相似的抑制活性，对VEGFR的选择性比PDGFR-α， CSF-1R和Flt3分别高36倍， 110倍 和1000倍以上。Phase 3。Cediranib (AZD2171) is a highly potent VEGFR(KDR) inhibitor with IC50 of <1 nM, also inhibits Flt1/4 with IC50 of 5 nM/≤3 nM, similar activity against c-Kit and PDGFRβ, 36-, 110-fold and >1000-fold selective more for VEGFR than PDGFR-α, CSF-1R and Flt3, Phase 3.

ALogP：4.9

IUPAC Name：4-[(4-fluoro-2-methyl-1H-indol-5-yl)oxy]-6-methoxy-7-(3-pyrrolidin-1-ylpropoxy)quinazoline

INCHI：InChI=1S/C25H27FN4O3/c1-16-12-17-19(29-16)6-7-21(24(17)26)33-25-18-13-22(31-2)23(14-20(18)27-15-28-25)32-11-5-10-30-8-3-4-9-30/h6-7,12-15,29H,3-5,8-11H2,1-2H3

InChi Key：XXJWYDDUDKYVKI-UHFFFAOYSA-N

Canonical SMILES：CC1=CC2=C(N1)C=CC(=C2F)OC3=NC=NC4=CC(=C(C=C43)OC)OCCCN5CCCC5

Isomeric SMILES：CC1=CC2=C(N1)C=CC(=C2F)OC3=NC=NC4=CC(=C(C=C43)OC)OCCCN5CCCC5

PubChem CID：9933475

CAS Registry No.：288383-20-0

Wikipedia：Cediranib

DiscoveRx TREEspot：AZD-2171|

ChEMBL Ligand：CHEMBL491473

Reactome Reaction：R-HSA-2023462, R-HSA-2029992

Reactome Drug：R-ALL-2023377

溶解性：DMSO 90 mg/mL Water <1 mg/mL Ethanol <1 mg/mL

象形图：

信号词：Danger

危险声明：H315 Causes skin irritationH301 Toxic if swallowedH312 Harmful in contact with skinH410 Very toxic to aquatic life with long lasting effectsH372 Causes damage to organs through prolonged or repeated exposureH361 Suspected of damaging fertility or the unborn child

预防措施声明：P273,P280,P302+P352,P321,P405,P501,P264,P260,P270,P362+P364,P391,P330,P203,P301+P316,P318,P317,P332+P317,P319

产品包装