产品名称

英文名称：(3S,4S)-Tofacitinib

同义词

1-PIPERIDINEPROPANENITRILE, 4-METHYL-3-(METHYL-7H-PYRROLO(2,3-D)PYRIMIDIN-4-YLAMINO)-.BETA.-OXO-, (3S,4S)-、3-[(3S,4S)-4-methyl-3-[methyl(7H-pyrrolo[2,3-d]pyrimidin-4-yl)amino]piperidin-1-yl]-3-oxopropanenitrile、CS-1108、NCGC00348153-01、racemic-Tasocitinib、(3S,4S)-托法替尼

产品性质

CAS编号：1092578-47-6

分子式：C16H20N6O

分子量：312.37

PubChem编号：20111936

别名：(3S,4S)-托法替尼

英文别名：1-PIPERIDINEPROPANENITRILE, 4-METHYL-3-(METHYL-7H-PYRROLO(2,3-D)PYRIMIDIN-4-YLAMINO)-.BETA.-OXO-, (3S,4S)-|3-[(3S,4S)-4-methyl-3-[methyl(7H-pyrrolo[2,3-d]pyrimidin-4-yl)amino]piperidin-1-yl]-3-oxopropanenitrile|CS-1108|NCGC00348153-01|racemic-Tasocitinib|

规格或纯度：96%

英文名称：(3S,4S)-Tofacitinib

生化机理：Tasocitinib also known as CP690550 is an JAK kinase inhibitor. An IC50 estimated at 0.2 μM for PV patient progenitor cells.

储存温度：-20°C储存

运输条件：超低温冰袋运输

产品介绍：Tofacitinib是高效JAK3抑制剂，IC50为1 nM，比对JAK2和JAK1的抑制性高20倍和100倍。Tofacitinib is a novel inhibitor of JAK3 with IC50 of 1 nM, 20- to 100-fold less potent against JAK2 and JAK1.

PubChem SID：488199775

IUPAC Name：3-[(3S,4S)-4-methyl-3-[methyl(7H-pyrrolo[2,3-d]pyrimidin-4-yl)amino]piperidin-1-yl]-3-oxopropanenitrile

INCHI：InChI=1S/C16H20N6O/c1-11-5-8-22(14(23)3-6-17)9-13(11)21(2)16-12-4-7-18-15(12)19-10-20-16/h4,7,10-11,13H,3,5,8-9H2,1-2H3,(H,18,19,20)/t11-,13+/m0/s1

InChi Key：UJLAWZDWDVHWOW-WCQYABFASA-N

Canonical SMILES：CC1CCN(CC1N(C)C2=NC=NC3=C2C=CN3)C(=O)CC#N

Isomeric SMILES：C[C@H]1CCN(C[C@H]1N(C)C2=NC=NC3=C2C=CN3)C(=O)CC#N

PubChem CID：20111936

溶解性：DMSO 100 mg/mL Ethanol 100 mg/mL

产品包装