产品名称

英文名称：TPCA-1

同义词

TPCA-1、507475-17-4、5-(4-Fluorophenyl)-2-ureidothiophene-3-carboxamide、IKK-2 Inhibitor IV、TPCA1、2-(carbamoylamino)-5-(4-fluorophenyl)thiophene-3-carboxamide、[5-(p-Fluorophenyl)-2-ureido]thiophene-3-carboxamide、IKK2 Inhibitor IV、IKK 2 Inhibitor IV、TPCA 1、CH

产品性质

CAS编号：507475-17-4

分子式：C12H10FN3O2S

分子量：279.29

MDL号：MFCD09037541

PubChem编号：9903786

英文别名：TPCA-1|507475-17-4|5-(4-Fluorophenyl)-2-ureidothiophene-3-carboxamide|IKK-2 Inhibitor IV|TPCA1|2-(carbamoylamino)-5-(4-fluorophenyl)thiophene-3-carboxamide|[5-(p-Fluorophenyl)-2-ureido]thiophene-3-carboxamide|IKK2 Inhibitor IV|IKK 2 Inhibitor IV|TPCA 1|CH

规格或纯度：≥98%

英文名称：TPCA-1

生化机理：TPCA-1 is potent, selective inhibitor of IκB kinase-2 (IKK-2) (IC50 = 17.9 nM) that displays > 22-fold selectivity over IKK-1 and > 550-fold selectivity over other kinases and enzymes. TPCA-1 inhibits production of pro-inflammatory cytokines in vitro and in vivo and inhibits NF-κB nuclear localization. TPCA-1 reduces the severity and onset of collagen-induced arthritis; anti-inflammatory.Potent, selective IκB kinase inhibitor (IC 50 = 17.9 nM). Inhibits NF-κB nuclear localization. Shows anti-inflammatory effects in vivo.

储存温度：-20°C储存

运输条件：超低温冰袋运输

备注：如果有可能，您尽量在使用的当天配置溶液，并在当天使用完它。但是，如果您需要预先配制储备溶液，我们建议您将溶液等份保存在-20°C的密封小瓶中。通常，它们最多可以使用一个月。在使用前和打开样品瓶之前，我们建议您让您的产品在室温下平衡至少1小时。需要更多关于溶解度，用法和处理的建议吗？请访问我们的常见问题（FAQ）页面以获取更多详细信息。

产品介绍：TPCA-1是IKK-2选择性抑制剂，IC50为17.9 nM，对IKK-1有22倍以上的选择性，对其它激酶则有超过550倍的选择性。A potent inhibitor of IKKβ (IKK-2)TPCA-1 is potent, selective inhibitor of IKK-2 (IC50 = 17.9 nM) that displays > 22-fold selectivity over IKK-1 and > 550-fold selectivity over other kinases and enzymes.A potent inhibitor of IKKβ (IKK-2)

IUPAC Name：2-(carbamoylamino)-5-(4-fluorophenyl)thiophene-3-carboxamide

INCHI：InChI=1S/C12H10FN3O2S/c13-7-3-1-6(2-4-7)9-5-8(10(14)17)11(19-9)16-12(15)18/h1-5H,(H2,14,17)(H3,15,16,18)

InChi Key：SAYGKHKXGCPTLX-UHFFFAOYSA-N

Canonical SMILES：C1=CC(=CC=C1C2=CC(=C(S2)NC(=O)N)C(=O)N)F

Isomeric SMILES：C1=CC(=CC=C1C2=CC(=C(S2)NC(=O)N)C(=O)N)F

WGK Germany：3

PubChem CID：9903786

ChEMBL Ligand：CHEMBL257167

CAS Registry No.：507475-17-4

RCSB PDB Ligand：NM7

溶解性：DMSO 56 mg/mL Water <1 mg/mL Ethanol <1 mg/mL

象形图：

信号词：Warning

危险声明：H319 Causes serious eye irritationH302 Harmful if swallowed

预防措施声明：P305+P351+P338,P280,P501,P264,P270,P330,P264+P265,P301+P317,P337+P317

个人防护装备：dust mask type N95 (US), Eyeshields, Gloves

产品包装