产品名称

英文名称：Rimonabant

同义词

5-(4-chlorophenyl)-1-(2,4-dichlorophenyl)-4-methyl-N-(piperidin-1-yl)-1H-pyrazole-3-carboxamide、s3021、(N-(Piperidin-1-yl)-5-(4-chlorophenyl)-4-methyl-1H-pyrazole-3-carboxamide、158681-13-1 (HCl)、AY6、BR164345、GTPL743、SB19549、W-108076、1H-Pyrazole-3-carboxami、利莫那班

产品性质

CAS编号：168273-06-1

分子式：C22H21Cl3N4O

分子量：463.79

MDL号：MFCD04034714

PubChem编号：104850

别名：利莫那班

英文别名：5-(4-chlorophenyl)-1-(2,4-dichlorophenyl)-4-methyl-N-(piperidin-1-yl)-1H-pyrazole-3-carboxamide|s3021|(N-(Piperidin-1-yl)-5-(4-chlorophenyl)-4-methyl-1H-pyrazole-3-carboxamide|158681-13-1 (HCl)|AY6|BR164345|GTPL743|SB19549|W-108076|1H-Pyrazole-3-carboxami

规格或纯度：≥98%

英文名称：Rimonabant

生化机理：Rimonabant, also known as SR141716, was the first selective CB1 (cannabinoid 1) central receptor inverse agonist (Ki = 1.8 nM). It is widely used as a tool to investigate CB receptor properties and the mechanisms by which CB agonists exert their pharmacological effects. In rodent models and clinical trials, rimonabant effectively induces lipolysis, reduces hepatomegaly, decreases body weight, and improves dyslipidemia by reducing triglyceride, free fatty acid, and total cholesterol levels and by increasing HDL/LDL ratios. However, rimonabant reportedly produces adverse psychiatric and neurological effects (e.g., depression or anxiety) and therefore is not approved by the FDA for use as a weight control medication. Rimonabant elicits antiproliferative and immunomodulatory effects (e.g., cell cycle arrest, increased expression of IκB and phosphorylated Akt, and decreased expression of NF-κB, phosphorylated ERK1/2, COX-2, and iNOS) in vitro.Potent and selective cannabinoid CB1 receptor antagonist/inverse agonist (K i = 2 nM). Shows anoretic, antiobesogenic and central psychoactive effects in vivo. Blood-brain barrier permeable. Orally active.

储存温度：2-8°C储存

运输条件：冰袋运输

备注：如果有可能，您尽量在使用的当天配置溶液，并在当天使用完它。但是，如果您需要预先配制储备溶液，我们建议您将溶液等份保存在-20°C的密封小瓶中。通常，它们最多可以使用一个月。在使用前和打开样品瓶之前，我们建议您让您的产品在室温下平衡至少1小时。需要更多关于溶解度，用法和处理的建议吗？请访问我们的常见问题（FAQ）页面以获取更多详细信息。

产品介绍：Rimonabant是一个大脑中心大麻素受体（CB1）特异性口服拮抗剂。在hCB1转染HEK293细胞中IC50浓度为13.6 nM，EC50浓度为17.3 nM。An immunomodulatory CB1 receptor inverse agonist.Rimonabant is a selective antagonist of CB1 with IC50 of 13.6 nM and EC50 of 17.3 nM in hCB1 transfected HEK 293 membrane.An immunomodulatory CB1 receptor inverse agonist.

ALogP：6.5

IUPAC Name：5-(4-chlorophenyl)-1-(2,4-dichlorophenyl)-4-methyl-N-piperidin-1-ylpyrazole-3-carboxamide

INCHI：InChI=1S/C22H21Cl3N4O/c1-14-20(22(30)27-28-11-3-2-4-12-28)26-29(19-10-9-17(24)13-18(19)25)21(14)15-5-7-16(23)8-6-15/h5-10,13H,2-4,11-12H2,1H3,(H,27,30)

InChi Key：JZCPYUJPEARBJL-UHFFFAOYSA-N

Canonical SMILES：CC1=C(N(N=C1C(=O)NN2CCCCC2)C3=C(C=C(C=C3)Cl)Cl)C4=CC=C(C=C4)Cl

Isomeric SMILES：CC1=C(N(N=C1C(=O)NN2CCCCC2)C3=C(C=C(C=C3)Cl)Cl)C4=CC=C(C=C4)Cl

PubChem CID：104850

溶解性：Soluble in ethanol (~20 mg/ml), DMSO (25 mg/ml), DMF (~20 mg/ml), and water (<1 mg/ml).

象形图：

信号词：Danger

危险声明：H410 Very toxic to aquatic life with long lasting effectsH372 Causes damage to organs through prolonged or repeated exposure

预防措施声明：P273,P501,P264,P260,P270,P391,P319

产品包装