产品名称

英文名称：Zearalenone from Giberella zeae

同义词

(3S,11E)-3,4,5,6,9,10-Hexahydro-14, 16-dihydroxy-3-methyl-1H-2-benzoxacyclotetradecin- 1,7(8H)-dione 、 CCRIS 623 、 1H-2-Benzoxacyclotetradecin-1,7(8H)-dione, 3,4,5,6,9,10-hexahydro-14,16-dihydroxy-3-methyl-, (S)-(-)- 、 CS-0027914 、 (S,E)-14,16-Dihydroxy-3、玉米赤霉烯酮 、 F-2毒素 、 (3S,11E)-14,16-二羟基-3-甲基-3,4,5,6,9,10-六氢-1H-2-苯并氧杂环十四碳烯-1,7(8H)-二酮

产品性质

CAS编号：17924-92-4

分子式：C18H22O5

分子量：318.36

Beilstein号：1350216

EC号：200-835-2

MDL号：MFCD00133085

PubChem编号：5281576

别名：玉米赤霉烯酮 | F-2毒素 | (3S,11E)-14,16-二羟基-3-甲基-3,4,5,6,9,10-六氢-1H-2-苯并氧杂环十四碳烯-1,7(8H)-二酮

英文别名：(3S,11E)-3,4,5,6,9,10-Hexahydro-14, 16-dihydroxy-3-methyl-1H-2-benzoxacyclotetradecin- 1,7(8H)-dione | CCRIS 623 | 1H-2-Benzoxacyclotetradecin-1,7(8H)-dione, 3,4,5,6,9,10-hexahydro-14,16-dihydroxy-3-methyl-, (S)-(-)- | CS-0027914 | (S,E)-14,16-Dihydroxy-3

规格或纯度：≥98%

英文名称：Zearalenone from Giberella zeae

生化机理：Zearalenone, a fungal mycotoxin produced by Fusarium, binds the estrogen receptor (ER) and is uterotropic in the newborn rat. It is a common contaminant in cereal grain used for animal and human food, and exerts an estrogenic activity that modulates/disrupts endocrine function in animals and possibly humans.Mixed potent, nonsteroidal ERα and ERβ ligand (IC 50 values are 56 and 41 nM for ERα and ERβ respectively). Shows agonist effects at lower doses. Partially selective for ERα activation. Induces apoptosis in male germ cells. Active in vivo.

储存温度：-20°C储存

运输条件：超低温冰袋运输

备注：如果有可能，您尽量在使用的当天配置溶液，并在当天使用完它。但是，如果您需要预先配制储备溶液，我们建议您将溶液等份保存在-20°C的密封小瓶中。通常，它们最多可以使用一个月。在使用前和打开样品瓶之前，我们建议您让您的产品在室温下平衡至少1小时。需要更多关于溶解度，用法和处理的建议吗？请访问我们的常见问题（FAQ）页面以获取更多详细信息。

产品介绍：Zearalenone, a phytoestrogenic mycotoxin usually produced by Fusarium species, is shown to be a cytotoxic compound, but alos binds to the estrogen receptor (ER) (IC50 values are 166 and 240 nM for ERβ and ERα respectively) and was found to stimulate the transcriptional activity of both subtypes at concentrations between 1 - 10 nM. This agent has demonstrated the ability to induce apoptosis via activation of mitochondrial release of Cytochrome c, production of reactive oxygen species (ROS), activation of caspase-3 and caspase-8, and induction of endoplasmic reticulum stress. Additional studies sμggest that Zearalenone also up-regulates Bax expression and down-regulates Bcl-xL expression in cells, which also contribute to a halt in cell proliferation. The cell growth arrests caused by this mycotoxin seem to take place during the G1 phase of the cell cycle.A phytoestrogenic mycotoxin and ER activatorZearalenone, a phytoestrogenic mycotoxin usually produced by Fusarium species, is shown to be a cytotoxic compound, but alos binds to the estrogen receptor (ER) (IC50 values are 166 and 240 nM for ERβ and ERα respectively) and was found to stimulate the transcriptional activity of both subtypes at concentrations between 1 - 10 nM. This agent has demonstrated the ability to induce apoptosis via activation of mitochondrial release of Cytochrome c, production of reactive oxygen species (ROS), activation of caspase-3 and caspase-8, and induction of endoplasmic reticulum stress. Additional studies suggest that Zearalenone also up-regulates Bax expression and down-regulates Bcl-xL expression in cells, which also contribute to a halt in cell proliferation. The cell growth arrests caused by this mycotoxin seem to take place during the G1 phase of the cell cycle.A phytoestrogenic mycotoxin and ER activator

IUPAC Name：(4S,12E)-16,18-dihydroxy-4-methyl-3-oxabicyclo[12.4.0]octadeca-1(14),12,15,17-tetraene-2,8-dione

INCHI：InChI=1S/C18H22O5/c1-12-6-5-9-14(19)8-4-2-3-7-13-10-15(20)11-16(21)17(13)18(22)23-12/h3,7,10-12,20-21H,2,4-6,8-9H2,1H3/b7-3+/t12-/m0/s1

InChi Key：MBMQEIFVQACCCH-QBODLPLBSA-N

Canonical SMILES：CC1CCCC(=O)CCCC=CC2=C(C(=CC(=C2)O)O)C(=O)O1

Isomeric SMILES：C[C@H]1CCCC(=O)CCC/C=C/C2=C(C(=CC(=C2)O)O)C(=O)O1

WGK Germany：3

PubChem CID：5281576

UN Number：3261

Packing Group：I

溶解性：不溶于水，可溶于苯、醇、乙醚

密度：1.168

敏感性：对光线、热敏感

闪点(℉)：6 °C

闪点(℃)：6°C

熔点：162 °C

象形图：

信号词：Danger

危险声明：H314 Causes severe skin burns and eye damageH361 Suspected of damaging fertility or the unborn child

预防措施声明：P280,P321,P405,P501,P264,P260,P301+P330+P331,P304+P340,P363,P203,P305+P354+P338,P318,P302+P361+P354,P316

Class：8

个人防护装备：Eyeshields,Faceshields,full-face respirator (US),Gloves,multi-purpose combination respirator cartridge (US),type ABEK (EN14387) respirator filter

产品包装