产品名称

英文名称：GMX1778

同义词

200484-11-3、CHS-828、GMX1778、CHS 828、CHS828、GMX 1778、GMX-1778、2-[6-(4-chlorophenoxy)hexyl]-1-cyano-3-pyridin-4-ylguanidine、8LAP87DNSZ、Guanidine, N-[6-(4-chlorophenoxy)hexyl]-N'-cyano-N''-4-pyridinyl-、CHEMBL17289、GMX1778 (CHS828)、1-[6-(4-Chlorophenoxy)hexyl、1-(6-(4-氯苯氧基)己基)-3-氰基-2-(吡啶-4-基)胍

产品性质

CAS编号：200484-11-3

分子式：C19H22ClN5O

分子量：371.86

PubChem编号：148198

别名：1-(6-(4-氯苯氧基)己基)-3-氰基-2-(吡啶-4-基)胍

英文别名：200484-11-3|CHS-828|GMX1778|CHS 828|CHS828|GMX 1778|GMX-1778|2-[6-(4-chlorophenoxy)hexyl]-1-cyano-3-pyridin-4-ylguanidine|8LAP87DNSZ|Guanidine, N-[6-(4-chlorophenoxy)hexyl]-N'-cyano-N''-4-pyridinyl-|CHEMBL17289|GMX1778 (CHS828)|1-[6-(4-Chlorophenoxy)hexyl

规格或纯度：98% (HPLC)

英文名称：GMX1778

生化机理：GMX1778 (CHS-828) is a competitive inhibitor of nicotinamide phosphoribosyltransferase (NAMPT) that exhibits a potent anticancer activity both in vitro and in vivo. GMX1778 exerts a cytotoxic effect by decreasing the cellular level of NAD+. GMX1778 increases intracellular ROS in cancer cells but does not induce ROS in normal cells. GMX1778 can regulate redox status and has the ability to simulate ROS in cancer cells.NF-κβ inhibitor. Potent antineoplastic agent. Shows antitumor effects in vivo. Orally active.

储存温度：-20°C储存

运输条件：超低温冰袋运输

备注：如果有可能，您尽量在使用的当天配置溶液，并在当天使用完它。但是，如果您需要预先配制储备溶液，我们建议您将溶液等份保存在-20°C的密封小瓶中。通常，它们最多可以使用一个月。在使用前和打开样品瓶之前，我们建议您让您的产品在室温下平衡至少1小时。需要更多关于溶解度，用法和处理的建议吗？请访问我们的常见问题（FAQ）页面以获取更多详细信息。

产品介绍：GMX1778 has been used as NAMPT inhibitor, to study its effects on nicotinamide adenine dinucleotide (NAD) contents of SH-SY5Y cells exposed to Vacor.GMX1778 has been used as NAMPT inhibitor, to study its effects on nicotinamide adenine dinucleotide (NAD) contents of SH-SY5Y cells exposed to Vacor.

IUPAC Name：2-[6-(4-chlorophenoxy)hexyl]-1-cyano-3-pyridin-4-ylguanidine

INCHI：InChI=1S/C19H22ClN5O/c20-16-5-7-18(8-6-16)26-14-4-2-1-3-11-23-19(24-15-21)25-17-9-12-22-13-10-17/h5-10,12-13H,1-4,11,14H2,(H2,22,23,24,25)

InChi Key：BOIPLTNGIAPDBY-UHFFFAOYSA-N

Canonical SMILES：C1=CC(=CC=C1OCCCCCCN=C(NC#N)NC2=CC=NC=C2)Cl

Isomeric SMILES：C1=CC(=CC=C1OCCCCCCN=C(NC#N)NC2=CC=NC=C2)Cl

WGK Germany：3

PubChem CID：148198

象形图：

信号词：Warning

危险声明：H315 Causes skin irritationH319 Causes serious eye irritationH335 May cause respiratory irritationH302 Harmful if swallowed

预防措施声明：P261,P305+P351+P338,P280,P302+P352,P321,P405,P501,P264,P271,P270,P304+P340,P403+P233,P362+P364,P330,P264+P265,P301+P317,P337+P317,P332+P317,P319

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