产品名称

英文名称：Masitinib (AB1010)

同义词

4-((4-METHYLPIPERAZIN-1-YL)METHYL)-N-(4-METHYL-3-((4-PYRIDIN-3-YL-1,3-THIAZOL-2-YL)AMINO)PHENYL)BENZAMIDE、Masitinib (AB1010)、Masitinib [INN]、Masatinib、Masitinib、A839556、AKOS025312306、DB11526、HMS3244J12、Mastinib、GTPL5656、MASITINIB [WHO-DD]、Q1907109、4-[(4-M、马赛替尼

产品性质

CAS编号：790299-79-5

分子式：C28H30N6OS

分子量：498.65

PubChem编号：10074640

别名：马赛替尼

英文别名：4-((4-METHYLPIPERAZIN-1-YL)METHYL)-N-(4-METHYL-3-((4-PYRIDIN-3-YL-1,3-THIAZOL-2-YL)AMINO)PHENYL)BENZAMIDE|Masitinib (AB1010)|Masitinib [INN]|Masatinib|Masitinib|A839556|AKOS025312306|DB11526|HMS3244J12|Mastinib|GTPL5656|MASITINIB [WHO-DD]|Q1907109|4-[(4-M

规格或纯度：≥98%

英文名称：Masitinib (AB1010)

生化机理：Masitinib (AB1010) is a tyrosine kinase, c-Kit, PDGFR, FGFR3, the FAK pathway inhibitor with IC50 of 150 ± 80, 200 ± 40 nM for KIT tyrosine phosphorylation and the recombinant wild-type KIT. Masitinib can enhance the antiproliferative effects of gemcitabine (GEM) in pancreatic cancer cells. Masitinib potently inhibits KIT with activating mutations in the juxtamembrane domain.

储存温度：-20°C储存

运输条件：超低温冰袋运输

备注：25mg、100mg卖完停产，不再备货

产品介绍：Masitinib (AB1010)是一种新型的Kit和PDGFRα/β抑制剂，IC50分别为200 nM和540 nM/800 nM，但对ABL和c-Fms抑制作用较弱。Phase 3A tyrosine kinase, c-Kit, PDGFR, FGFR3, the FAK pathway inhibitor.Masitinib is a novel inhibitor for Kit and PDGFRα/β with IC50 of 200 nM and 540 nM/800 nM, weak inhibition to ABL and c-Fms. Phase 3.A tyrosine kinase, c-Kit, PDGFR, FGFR3, the FAK pathway inhibitor.

ALogP：4.3

IUPAC Name：4-[(4-methylpiperazin-1-yl)methyl]-N-[4-methyl-3-[(4-pyridin-3-yl-1,3-thiazol-2-yl)amino]phenyl]benzamide

INCHI：InChI=1S/C28H30N6OS/c1-20-5-10-24(16-25(20)31-28-32-26(19-36-28)23-4-3-11-29-17-23)30-27(35)22-8-6-21(7-9-22)18-34-14-12-33(2)13-15-34/h3-11,16-17,19H,12-15,18H2,1-2H3,(H,30,35)(H,31,32)

InChi Key：WJEOLQLKVOPQFV-UHFFFAOYSA-N

Canonical SMILES：CC1=C(C=C(C=C1)NC(=O)C2=CC=C(C=C2)CN3CCN(CC3)C)NC4=NC(=CS4)C5=CN=CC=C5

Isomeric SMILES：CC1=C(C=C(C=C1)NC(=O)C2=CC=C(C=C2)CN3CCN(CC3)C)NC4=NC(=CS4)C5=CN=CC=C5

PubChem CID：10074640

CAS Registry No.：790299-79-5

Wikipedia：Masitinib

DiscoveRx TREEspot：AB-1010|

ChEMBL Ligand：CHEMBL1908391

RCSB PDB Ligand：G65

Reactome Reaction：R-HSA-2077420, R-HSA-9669854, R-HSA-9669900, R-HSA-9669863, R-HSA-9674430, R-HSA-9674095

Reactome Drug：R-ALL-2077524

溶解性：DMSO 00 mg/mL (200.54 mM);Water <1 mg/mL (<1 mM);Ethanol 4 mg/mL (8.02 mM)

产品包装